Residential proximity to power lines and risk of brain tumor in the general population

Carles, Camille; Esquirol, Yolande; Turuban, Maxime; Piel, Clément; Migault, Lucile; Pouchieu, Camille; Bouvier, Ghislaine; Fabbro‐Peray, Pascale; Lebailly, Pierre; Baldi, Isabelle

doi:10.1016/j.envres.2020.109473

Cited by 17 publications

(13 citation statements)

References 32 publications

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“…Power lines are another source of EMF exposure that have been investigated in relation to brain and other CNS tumor risk. A recent case-control study found a significant association between the highest level of estimated ELF from power lines and increased risk of brain and other CNS tumors, and glioma in particular [26]. More investigation is necessary to confirm this association.…”

Section: Updates On Causes and Risk Factors For Brain And Other Cns Tumors In Adultsmentioning

confidence: 98%

Epidemiology of Brain and Other CNS Tumors

Ostrom

Francis

Barnholtz‐Sloan

2021

Curr Neurol Neurosci Rep

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Purpose of Review Brain and other central nervous system (CNS) tumors, while rare, cause significant morbidity and mortality across all ages. This article summarizes the current state of the knowledge on the epidemiology of brain and other CNS tumors. Recent Findings For childhood and adolescent brain and other CNS tumors, high birth weight, non-chromosomal structural birth defects and higher socioeconomic position were shown to be risk factors. For adults, increased leukocyte telomere length, proportion of European ancestry, higher socioeconomic position, and HLA haplotypes increase risk of malignant brain tumors, while immune factors decrease risk. Summary Although no risk factor accounting for a large proportion of brain and other CNS tumors has been discovered, the use of high throughput “omics” approaches and improved detection/measurement of environmental exposures will help us refine our current understanding of these factors and discover novel risk factors for this disease.

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Section: Updates On Causes and Risk Factors For Brain And Other Cns Tumors In Adultsmentioning

confidence: 98%

Epidemiology of Brain and Other CNS Tumors

Ostrom

Francis

Barnholtz‐Sloan

2021

Curr Neurol Neurosci Rep

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“…Both methods give little or no information on historical exposure to ELF MF. Indirect methods include geographical information system (GIS) which have been used along with declarative data, such as residential history, to assess residential ELF MF exposure in the general population [62][63][64][65]. Case-control studies that are based on death certificates revealed an association between adult brain tumor mortality and living less than 50 m (odd ratios, OR 1.10 95%, CI 0.74-1.64) [66] or 100 m (OR 2.99, 95%, CI 0.86-10.40) [67] from power lines.…”

Section: Brain Tumormentioning

confidence: 99%

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Maffei

2022

IJMS

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Humans are exposed to a complex mix of man-made electric and magnetic fields (MFs) at many different frequencies, at home and at work. Epidemiological studies indicate that there is a positive relationship between residential/domestic and occupational exposure to extremely low frequency electromagnetic fields and some types of cancer, although some other studies indicate no relationship. In this review, after an introduction on the MF definition and a description of natural/anthropogenic sources, the epidemiology of residential/domestic and occupational exposure to MFs and cancer is reviewed, with reference to leukemia, brain, and breast cancer. The in vivo and in vitro effects of MFs on cancer are reviewed considering both human and animal cells, with particular reference to the involvement of reactive oxygen species (ROS). MF application on cancer diagnostic and therapy (theranostic) are also reviewed by describing the use of different magnetic resonance imaging (MRI) applications for the detection of several cancers. Finally, the use of magnetic nanoparticles is described in terms of treatment of cancer by nanomedical applications for the precise delivery of anticancer drugs, nanosurgery by magnetomechanic methods, and selective killing of cancer cells by magnetic hyperthermia. The supplementary tables provide quantitative data and methodologies in epidemiological and cell biology studies. Although scientists do not generally agree that there is a cause-effect relationship between exposure to MF and cancer, MFs might not be the direct cause of cancer but may contribute to produce ROS and generate oxidative stress, which could trigger or enhance the expression of oncogenes.

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“…In 2002, ELF-MFs have been classified as possible carcinogens (2B) for humans by the International Agency for Research on Cancer (IARC) on the basis of epidemiological studies that associated ELF-MF exposure with an increased risk for childhood leukaemia (IARC 2002 ). Since then, various epidemiological and experimental studies have been performed to evaluate the carcinogenicity of ELF-MF exposure (Juutilainen et al 2006 ; Erdal et al 2007 ; Magnani et al 2014 ; Salvan et al 2015 ; Schüz et al 2016 ; Soffritti et al 2016a , b ; Campos-Sanchez et al 2019 ; Carles et al 2020 ), but the results were not conclusive and the question is still unanswered. Recently ELF-MF exposure has been associated with an increased risk of neurological disorders (Qiu et al 2004 ; Consales et al 2012 ; Brouwer et al 2015 ; Pedersen et al 2017 ; Jalilian et al 2018 ; Huss et al 2018 ), but the underlying molecular mechanisms are not fully understood.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

Giorgi

2021

Cell Tissue Res

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Epigenetic mechanisms regulate gene expression, without changing the DNA sequence, and establish cell-type-specific temporal and spatial expression patterns. Alterations of epigenetic marks have been observed in several pathological conditions, including cancer and neurological disorders. Emerging evidence indicates that a variety of environmental factors may cause epigenetic alterations and eventually influence disease risks. Humans are increasingly exposed to extremely low-frequency magnetic fields (ELF-MFs), which in 2002 were classified as possible carcinogens by the International Agency for Research on Cancer. This review summarizes the current knowledge of the link between the exposure to ELF-MFs and epigenetic alterations in various cell types. In spite of the limited number of publications, available evidence indicates that ELF-MF exposure can be associated with epigenetic changes, including DNA methylation, modifications of histones and microRNA expression. Further research is needed to investigate the molecular mechanisms underlying the observed phenomena.

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Residential proximity to power lines and risk of brain tumor in the general population

Cited by 17 publications

References 32 publications

Epidemiology of Brain and Other CNS Tumors

Epidemiology of Brain and Other CNS Tumors

Magnetic Fields and Cancer: Epidemiology, Cellular Biology, and Theranostics

Epigenetic dysregulation in various types of cells exposed to extremely low-frequency magnetic fields

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