Residential proximity to agricultural fumigant use and respiratory health in 7-year old children

Gunier, Robert B.; Raanan, Rachel; Castorina, Rosemary; Holland, Nina; Harley, Kim G.; Balmes, John R.; Fouquette, Laura; Eskenazi, Brenda; Bradman, Asa

doi:10.1016/j.envres.2018.02.022

Cited by 12 publications

(19 citation statements)

References 44 publications

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“…Childhood respiratory symptoms, asthma prevalence and pulmonary function changes were associated with elemental sulfur applications within 0.5 and 1 km radii of the residence [42], but non-significant associations were observed for residential proximity to fumigants used in the same cohort [43]. Furthermore, one study explored the children's school proximity to the cultivation areas with pesticide use and respiratory effects, and found that urinary CM metabolite levels (by ETU concentration) were significantly associated with an increased risk of asthma and rhinitis [44].…”

Section: Resultsmentioning

confidence: 89%

“…A population-based study in U.S. did not observe clear associations between asthma and OP and OC exposure (which was measured using biomarkers of DAP or DDT insecticides) among school-aged children [21]. No significant associations were observed between residential proximity to fumigant use during pregnancy and from birth to age 7 (assessed through the pesticide use registration in California) and respiratory symptoms, use of asthma medication, and lung function measurements [43].…”

Section: Resultsmentioning

confidence: 92%

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Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Buralli

Dultra

Ribeiro

2020

IJERPH

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Pesticide exposure may affect children’s respiratory and allergic health, although results from epidemiological studies have not reached consensus. This review aims to analyze the scientific evidence on respiratory and allergic effects of exposure to agricultural pesticides in children aged up to 12 years old. The databases PubMed, Web of Science, Scielo, and Lilacs were screened to select articles published in English, Spanish, or Portuguese, and 21 articles were included in this review. Most investigations were conducted in North America (mostly in the United States), while no studies conducted in Latin America or Africa were found, despite their intensive use of pesticides. Children are exposed to pesticides through multiple pathways from the prenatal period throughout later developmental stages and may experience several respiratory effects. Most studies (79%) found positive associations with pesticide exposure and children’s respiratory and allergic effects such as asthma, wheezing, coughs, acute respiratory infections, hay fever, rhinitis, eczema, chronic phlegm, and lung function impairments. Contrastingly, 21% of the studies found no associations between pesticide exposure and children’s respiratory health. The vast differences among the characteristics of the studies hamper any comparison of the results. Exposure to pesticides may have several impacts on childhood respiratory health. More studies must be conducted, especially in low- and middle-income countries, preferably with comparable research protocols adapted to local realities. Efforts should be made to develop comprehensive risk mitigation strategies and behavioral interventions to reduce children’s exposure to pesticides used in agriculture and respiratory health effects, and to ensure healthy childhood growth.

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Section: Resultsmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 92%

Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Buralli

Dultra

Ribeiro

2020

IJERPH

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“…In support of a link between pesticide exposure and ASD, the Childhood Autism Risks from Genetics and Environment (CHARGE) study found a positive association between ASD and residential proximity to OP application during the second and third trimester of gestation in a population-based case control study in California [47]. In addition to ASD, deficits in cognition and attention were associated with residential proximity to OP use during gestation in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) Study in the Salinas Valley, California [17]. The level of OP metabolites in maternal urine during pregnancy was associated with deficits in social reciprocal behavior, which were more prominent in boys than girls in the Mount Sinai Children’s Environmental Health Center study [14].…”

Section: Introductionmentioning

confidence: 99%

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

et al. 2019

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Background Signs of pervasive developmental disorder and social deficits were reported in toddlers and children whose mothers were exposed to organophosphate pesticides during pregnancy. Deficits in social preference were reported in adult male mice exposed to chlorpyrifos on gestational days 12–15. This study aimed (a) to test the hypothesis that adult female and male mice that were exposed prenatally to subtoxic doses of chlorpyrifos would be impaired in social behavior and (b) to determine if prenatal chlorpyrifos altered the expression of transcripts for oxytocin in the hypothalamus. Pregnant mice were treated by gavage with corn oil vehicle or 2.5 mg/kg or 5 mg/kg of CPF on gestational days 12–15. Social preference, social and non-social conditioned place preference tasks were tested in adults. Expression of oxytocin transcripts in hypothalamus was measured by qPCR. Results Chlorpyrifos (5 mg/kg on GD 12–15) reduced the innate preference for a conspecific in a dose and sex dependent manner. Adult males exposed prenatally to 5 mg/kg CPF showed a reduction in social preference. Socially conditioned place preference was impaired in offspring of dams treated with either dose of CPF. Non-social appetitive place conditioning was impaired in offspring of dams exposed to 2.5 mg/kg, but not to 5 mg/kg chlorpyrifos. Prenatal chlorpyrifos treatment did not alter the expression of the oxytocin mRNA in the hypothalamus, although expression was significantly lower in females. Conclusions Prenatal chlorpyrifos induced innate and learned social deficits and non-specific conditioning deficits in adult mice in a sex-dependent manner. Males showed specific social deficits following the higher dose whereas both males and females showed a more generalized conditioning deficit following the intermediate dose.

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“…The few pesticide-respiratory health effect studies among children adopt the single-pollutant approach, and have shown both negative and null effects of pesticide exposure on lung function. 6,61,62 For example, a study by Raanan et al provides evidence of significant FEV 1 and FVC decreases with early life exposures to organophosphate pesticide in 7-year-old children in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study. 6 However, the authors explored early life exposure windows of children with no asthma, only in single-pollutant analyses.…”

Section: Discussionmentioning

confidence: 99%

“…More recently, another study on children from the same CHAMACOS cohort showed that exposure to agricultural fumigants including MeBr resulted in no adverse respiratory effects. 61 The authors again only conducted single-pollutant analyses, and do not explore complex and nonlinear synergistic effects that likely exist between other environmental exposures within and outside the domain of pesticides.…”

Section: Discussionmentioning

confidence: 99%

The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma

Benka-Coker

Hoskovec

Severson

et al. 2020

Environmental Research

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Residential proximity to agricultural fumigant use and respiratory health in 7-year old children

Abstract: Residential proximity to agricultural fumigant use during pregnancy and childhood did not adversely affect respiratory health in the children through 7 years of age. These findings should be explored in larger studies.

Cited by 12 publications

References 44 publications

Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Respiratory and Allergic Effects in Children Exposed to Pesticides—A Systematic Review

Impaired innate and conditioned social behavior in adult C57Bl6/J mice prenatally exposed to chlorpyrifos

The joint effect of ambient air pollution and agricultural pesticide exposures on lung function among children with asthma

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