Residential greenness, air pollution and incident neurodegenerative disease: A cohort study in China

Zhu, Zhanghang; Yang, Zongming; Yu, Luhua; Xu, Lisha; Wu, Yonghao; Zhang, Xinhan; Shen, Peng; Lin, Hongbo; Shui, Liming; Tang, Mengling; Jin, Mingjuan; Wang, Jianbing; Chen, Kun

doi:10.1016/j.scitotenv.2023.163173

Cited by 17 publications

(13 citation statements)

References 52 publications

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“…This increase is attributed to factors like the aging population, emergence of lifestyle related diseases like obesity, high blood pressure, and diabetes, and a myriad of environmental factors related to urbanization and the industrial revolution. One such example is air pollution which is associated with cognitive decline (Franz et al 2023), dementia (Gong et al 2023), faster cognitive decline in those with AD (Lee et al 2023), and incident neurodegenerative disease (Zhu et al 2023). Exposure to light at night could similarly be impacting the development or progression of dementia and neurodegenerative disease.…”

Section: Discussionmentioning

confidence: 99%

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Voigt,

Ouyang,

Keshavarzian

2024

Preprint

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Alzheimer disease (AD) prevalence has increased in the last century which can be attributed to increased lifespan, but environment is also important. This study evaluated the relationship between outdoor nighttime light exposure and AD prevalence in the United States. Higher outdoor nighttime light was associated with higher prevalence of AD. While atrial fibrillation, diabetes, hyperlipidemia, hypertension, and stroke were associated more strongly with AD prevalence than nighttime light intensity, nighttime light was more strongly associated with AD prevalence than alcohol abuse, chronic kidney disease, depression, heart failure, and obesity. Startlingly, nighttime light exposure more strongly associated with AD prevalence in those under the age of 65 than any other disease factor examined. These data indicate a need to investigate how nighttime light exposure influences AD pathogenesis.

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Section: Discussionmentioning

confidence: 99%

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Voigt,

Ouyang,

Keshavarzian

2024

Preprint

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“…Higher levels of greenness have been linked with lower risk for neurological disorders such as Alzheimer’s disease, Parkinson’s disease, dementia, and stroke ( 9 , 15 – 17 ). There is however relatively less longitudinal research evaluating the relationship between greenness and Alzheimer’s disease ( 14 , 49 ). The results of this longitudinal study demonstrate that consistently higher levels of greenness over a 5-year period are associated with 16% lower odds of a new Alzheimer’s disease condition (p<.002), supporting previous cross-sectional findings ( 9 , 10 ).…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Impacts of Precision Greenness on Alzheimer’s Disease

Brown,

Aitken,

Lombard

et al. 2024

J Prev Alz Dis

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Background The potential for greenness as a novel protective factor for Alzheimer’s disease (AD) requires further exploration. Objectives This study assesses prospectively and longitudinally the association between precision greenness - greenness measured at the micro-environmental level, defined as the Census block - and AD incidence. Design Older adults living in consistently high greenness Census blocks across 2011 and 2016 were compared to those living in consistently low greenness blocks on AD incidence during 2012–2016. Setting Miami-Dade County, Florida, USA. Participants 230,738 U.S. Medicare beneficiaries. Measurements U.S. Centers for Medicare and Medicaid Services Chronic Condition Algorithm for AD based on ICD-9 codes, Normalized Difference Vegetation Index, age, sex, race/ethnicity, neighborhood income, and walkability. Results Older adults living in the consistently high greenness tertile, compared to those in the consistently low greenness tertile, had 16% lower odds of AD incidence (OR=0.84, 95% CI: 0.76–0.94, p=0.0014), adjusting for age, sex, race/ethnicity, and neighborhood income. Age, neighborhood income and walkability moderated greenness’ relationship to odds of AD incidence, such that younger ages (65–74), lower-income, and non-car dependent neighborhoods may benefit most from high greenness. Conclusions High greenness, compared to low greenness, is associated with lower 5-year AD incidence. Residents who are younger and/or who reside in lower-income, walkable neighborhoods may benefit the most from high greenness. These findings suggest that consistently high greenness at the Census block-level, may be associated with reduced odds of AD incidence at a population level.

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“…Our findings, however, contradict those of various other investigations. Zhu et al determined that exposure to ambient PM 2.5 , but not NO 2 or PM 10 , for the long term, was related to PD development 22 . These inconsistencies may be attributed to differences in study design and other factors, such as the number of PD outcomes, including or excluding other gaseous pollutants, and variations in the constituent factors in PM across different regions.…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson’s disease

Huang,

Ma,

Gao

et al. 2024

npj Parkinsons Dis.

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Inconsistent findings exist regarding the potential association between polluted air and Parkinson’s disease (PD), with unclear insights into the role of inherited sensitivity. This study sought to explore the potential link between various air pollutants and PD risk, investigating whether genetic susceptibility modulates these associations. The population-based study involved 312,009 initially PD-free participants with complete genotyping data. Annual mean concentrations of PM2.5, PM10, NO2, and NOx were estimated, and a polygenic risk score (PRS) was computed to assess individual genetic risks for PD. Cox proportional risk models were employed to calculate hazard ratios (HR) and 95% confidence intervals (CI) for the associations between ambient air pollutants, genetic risk, and incident PD. Over a median 12.07-year follow-up, 2356 PD cases (0.76%) were observed. Compared to the lowest quartile of air pollution, the highest quartiles of NO2 and PM10 pollution showed HRs and 95% CIs of 1.247 (1.089–1.427) and 1.201 (1.052–1.373) for PD incidence, respectively. Each 10 μg/m3 increase in NO2 and PM10 yielded elevated HRs and 95% CIs for PD of 1.089 (1.026–1.155) and 1.363 (1.043–1.782), respectively. Individuals with significant genetic and PM10 exposure risks had the highest PD development risk (HR: 2.748, 95% CI: 2.145–3.520). Similarly, those with substantial genetic and NO2 exposure risks were over twice as likely to develop PD compared to minimal-risk counterparts (HR: 2.414, 95% CI: 1.912–3.048). Findings suggest that exposure to air contaminants heightens PD risk, particularly in individuals genetically predisposed to high susceptibility.

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Residential greenness, air pollution and incident neurodegenerative disease: A cohort study in China

Cited by 17 publications

References 52 publications

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Outdoor Nighttime Light Exposure (Light Pollution) is Associated with Alzheimer’s Disease

Longitudinal Impacts of Precision Greenness on Alzheimer’s Disease

Genetic susceptibility modifies the association of long-term air pollution exposure on Parkinson’s disease

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