Residential exposure to outdoor air pollution and adult lung function, with focus on small airway obstruction

Havet, Anaïs; Hulo, Sébastien; Cuny, Damien; Riant, Margaux; Occelli, Florent; Chérot‐Kornobis, Nathalie; Giovannelli, Jonathan; Matran, Régis; Amouyel, Philippe; Edmé, Jean-Louis; Dauchet, Luc

doi:10.1016/j.envres.2020.109161

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…Pulmonary function can be influenced by a variety of factors. Traditional epidemiologic studies have widely investigated the relationship of environmental factors, such as cigarette smoking [ 5 ] and air pollution [ 6 ] with pulmonary function. Besides, family-based study [ 7 ] and genome-wide association study (GWAS) [ 8 ] have estimated the heritability of pulmonary function ranging from 0.42 to 0.71, indicating genetic contribution to the variation of pulmonary function.…”

Section: Introductionmentioning

confidence: 99%

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Wang

et al. 2021

Respir Res

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Background Previous studies have determined the epigenetic association between DNA methylation and pulmonary function among various ethnics, whereas this association is largely unknown in Chinese adults. Thus, we aimed to explore epigenetic relationships between genome-wide DNA methylation levels and pulmonary function among middle-aged Chinese monozygotic twins. Methods The monozygotic twin sample was drawn from the Qingdao Twin Registry. Pulmonary function was measured by three parameters including forced expiratory volume the first second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratio. Linear mixed effect model was used to regress the methylation level of CpG sites on pulmonary function. After that, we applied Genomic Regions Enrichment of Annotations Tool (GREAT) to predict the genomic regions enrichment, and used comb-p python library to detect differentially methylated regions (DMRs). Gene expression analysis was conducted to validate the results of differentially methylated analyses. Results We identified 112 CpG sites with the level of P < 1 × 10–4 which were annotated to 40 genes. We identified 12 common enriched pathways of three pulmonary function parameters. We detected 39 DMRs located at 23 genes, of which PRDM1 was related to decreased pulmonary function, and MPL, LTB4R2, and EPHB3 were related to increased pulmonary function. The gene expression analyses validated DIP2C, ASB2, SLC6A5, and GAS6 related to decreased pulmonary function. Conclusion Our DNA methylation sequencing analysis on identical twins provides new references for the epigenetic regulation on pulmonary function. Several CpG sites, genes, biological pathways and DMRs are considered as possible crucial to pulmonary function.

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Section: Introductionmentioning

confidence: 99%

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Wang

et al. 2021

Respir Res

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“…This further supports our observation of elevated small airway obstruction in those who were screened early after exposure. Several other studies have reinforced evidence of the injurious effects of NO 2 on lung function, particularly on small airways (Gong et al 2008;Havet et al 2020). However, it has been noted that NO 2 and PM 2.5 coexist, and the effect of NO 2 on the lungs is enhanced by PM 2.5 (Gong et al 2008).…”

Section: Discussionmentioning

confidence: 91%

Short-term acute exposure to wildfire smoke and lung function in a Royal Canadian Mounted Police (RCMP) cohort

Moitra

Tabrizi

Fathy

et al. 2020

Preprint

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RationaleThe increasing incidence of extreme wildfire is becoming a concern for public health. Although long-term exposure to wildfire smoke is associated with respiratory illnesses, reports on the association between short-term occupational exposure to wildfire smoke and lung function remain scarce.MethodsIn this cross-sectional study, we analyzed data of 218 Royal Canadian Mounted Police officers (mean age: 38±9 years) deployed at the Fort McMurray wildfire in 2016. Individual exposure to air pollutants was calculated by integrating the duration of exposure with the air quality parameters obtained from the nearest air quality monitoring station during the phase of deployment. Lung function was measured using spirometry and body plethysmography. Association between exposure and lung function was examined using principal component linear regression analysis, adjusting for potential confounders.ResultsThe participants were predominantly male (71%). Mean forced expiratory volume in 1 second (FEV1), and residual volume (RV) were 76.5±5.9 and 80.1±19.5 (% predicted). A marginal association was observed between air pollution and higher RV [β: 1.55; 95%CI: -0.28 to 3.37 per interquartile change of air pollution index], but not with other lung function indices. The association between air pollution index and RV was significantly higher in participants who were screened within the first three months of deployment [2.80; 0.91 to 4.70] than those screened later [-0.28; -2.58 to 2.03], indicating a more acute effect of air pollution on peripheral airways.ConclusionAcute short-term exposure to wildfire-associated air pollutants may impose subtle but clinically important deleterious respiratory effects, particularly in the peripheral airways.

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“…2 ). The majority (60%) used either FEF 25–75 alone [ 21 – 28 ] or in combination with other parameters [ 13 , 29 – 34 ]. Three studies used FEF 25–75 /FVC [ 35 – 37 ].…”

Section: Resultsmentioning

confidence: 99%

Spirometry parameters used to define small airways obstruction in population-based studies: systematic review

et al. 2022

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Background The assessment of small airways obstruction (SAO) using spirometry is practiced in population-based studies. However, it is not clear what are the most used parameters and cut-offs to define abnormal results. Methods We searched three databases (Medline, Web of Science, Google Scholar) for population-based studies, published by 1 May 2021, that used spirometry parameters to identify SAO and/or provided criteria for defining SAO. We systematically reviewed these studies and summarised evidence to determine the most widely used spirometry parameter and criteria for defining SAO. In addition, we extracted prevalence estimates and identified associated risk factors. To estimate a pooled prevalence of SAO, we conducted a meta-analysis and explored heterogeneity across studies using meta regression. Results Twenty-five studies used spirometry to identify SAO. The most widely utilised parameter (15 studies) was FEF25–75, either alone or in combination with other measurements. Ten studies provided criteria for the definition of SAO, of which percent predicted cut-offs were the most common (5 studies). However, there was no agreement on which cut-off value to use. Prevalence of SAO ranged from 7.5% to 45.9%. As a result of high heterogeneity across studies (I2 = 99.3%), explained by choice of spirometry parameter and WHO region, we do not present a pooled prevalence estimate. Conclusion There is a lack of consensus regarding the best spirometry parameter or defining criteria for identification of SAO. The value of continuing to measure SAO using spirometry is unclear without further research using large longitudinal data. PROSPERO registration number CRD42021250206

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Residential exposure to outdoor air pollution and adult lung function, with focus on small airway obstruction

Cited by 29 publications

References 28 publications

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Genome-wide DNA methylation analysis of pulmonary function in middle and old-aged Chinese monozygotic twins

Short-term acute exposure to wildfire smoke and lung function in a Royal Canadian Mounted Police (RCMP) cohort

Spirometry parameters used to define small airways obstruction in population-based studies: systematic review

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