Resident cardiac progenitor cells: At the heart of regeneration

Bollini, Sveva; Smart, Nicola; Riley, Paul R.

doi:10.1016/j.yjmcc.2010.07.006

Cited by 144 publications

(98 citation statements)

References 95 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…After injury, the heart muscle displays very limited regeneration, in which resident cardiac progenitor cells (CPCs) seem to play a role. [1] Despite their acknowledged regenerative potential, [2][3][4] very little is known about the actual role of CPCs, particularly of human origin, in cardiac repair and regeneration. Among the different CPC populations that have been identified, human cardiomyocyte progenitor cells (CMPCs) represent a promising candidate for cardiac regeneration, due to their presence in fetal and adult heart, and the capacity to differentiate into the three cardiac lineages (cardiomyocytes, endothelial, and smooth muscle cells).…”

Section: Introductionmentioning

confidence: 99%

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

et al. 2017

View full text Add to dashboard Cite

Cardiac progenitor cells (CPCs) are a promising candidate for cardiac regeneration, and the interaction between CPCs and their microenvironment can influence their regenerative response. Notch signaling plays a key role in cell fate decisions in the developing and adult heart. Here, we investigated the effect of three-dimensional (3D) spheroid culture, as a model of the 3D microenvironment, on Notch in fetal and adult human CPCs, under room air (20%) and physiological (5%) oxygen tension. Notch signaling is enhanced in 3D spheroids; spheroid culture under 5% O 2 further increases Notch signaling enhancement, and might ultimately improve the regenerative potential of CPCs.

show abstract

Section: Introductionmentioning

confidence: 99%

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Recent studies in the field ofcell therapy have shown new therapeutic potentials in the treatment of cardiac disease [27]. Previous studies had shown that various stem cell resources such as; bone marrow (BM-MSCs) [28], Embryonic (ESCs) [29], adipose tissue (ADCs) [12,30], cardiac (CSCs) [31] and umbilical cord blood stem cells (UCBSCs) [32] have beneficial effects on the restoration of cardiac function after MI, but practical application of these sources is limited. Low cell yields, invasive collection procedure, long culture periods, ethical issues and the risk of recipient immune reaction are but a few of the associated problems that prove to be serious and troublesome barriers in choosing a sufficient stem cell source.…”

Section: Discussionmentioning

confidence: 99%

Restoration of Heart Function Using Transplantation of Human Umbilical Cord Matrix-Derived Cardiomyocytes and Vascular Endothelial Growth Factor

Moradi¹,

Abbasi²,

Farid³

et al. 2013

TOTERMJ

View full text Add to dashboard Cite

Abstract:Objectives: In the previous study, although it has been shown that intramyocardial injection of human umbilical cord matrix stem cell (hUCM) improved cardiac function 4 weeks post MI, but angiogenesis has not been observed. Angiogenesis and replacing lost cardiomyocytes with new, live cardiomyocytes are considered as two key agents in cardiac repair. To achieve the above two factors we examined the effects of combination of stem cell and angiogenic therapy approaches by simultaneously injection of hUCM-derived cardiomyocytes with vascular endothelial growth factor (VEGF) in cardiac repair.Methods: MI-induced animals(by ligation of LAD) received 50 µl PBS, 5 × 10 6 differentiated hUCM cells (dhUCM), 5µg VEGF in normal saline and 5 × 10 6 dhUCM cells combined with 5µg VEGF in normal saline, intramyocardialy. MI group, with no other intervention, served as a control group. We were assessed survival, migration and integration of dhUCM cells, as well as angiogenesis eight weeks post MI induction.Results: Eight weeks post MI, although dhUCM and VEGF groups have shown that LVEF and LVFS improved significantly, but animals in dhUCM+VEGF group have the highest rise in LVEF and LVFS in comparison to the other MI-induced groups (p<0.05). Histological and morphological analysis have revealed that myocardium of animals in dhUCM+VEGF group have the highest vascular density and the lowest fibrosis tissue in comparison to the other MIinduced groups (p<0.05). Immunohistological assessments revealed that transplanted dhUCM cells have survived, migrated to infarcted area and integrated with recipient cardiac tissue. Conclusion:we have found that intramyocardial administration of dhUCM cells combined with VEGF improved cardiac function, enhanced angiogenesis and reduced fibrosis tissue formation after MI, eight weeks post MI.

show abstract

“…They demonstrated that c-kit+ CPC express the receptor for HMGB1 and that treatment increased the number of c-kit+ cells in mouse heart. Thymosine Beta4 has been shown to stimulate epicardial-derived cells (EPDC) to migrate and potentially promote neovascularization in the infarcted mouse heart (Smart et al, 2010); see review by (Bollini et al, 2011). Although there was no proof that EPDC were a source of the new cardiomyocytes, they may facilitate collateral vessel growth and thereby support the cardiomyocyte regeneration process.…”

Section: Alternatives To Cell Delivery: "Activation" Of Resident Cpcmentioning

confidence: 99%

Myocardial Self-Repair and Congenital Heart Disease

Chalajour¹,

Ma²,

Riemer³

2012

Congenital Heart Disease - Selected Aspects

View full text Add to dashboard Cite

Resident cardiac progenitor cells: At the heart of regeneration

Cited by 144 publications

References 95 publications

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

Spheroid three-dimensional culture enhances Notch signaling in cardiac progenitor cells

Restoration of Heart Function Using Transplantation of Human Umbilical Cord Matrix-Derived Cardiomyocytes and Vascular Endothelial Growth Factor

Myocardial Self-Repair and Congenital Heart Disease

Contact Info

Product

Resources

About