Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

Balsalobre, Aurélio; Brown, Steven A.; Marcacci, Lysiane; Tronche, François; Kellendonk, Christoph; Reichardt, Holger M.; Schütz, Günther; Schibler, Ueli

doi:10.1126/science.289.5488.2344

Cited by 1,597 publications

(1,454 citation statements)

References 20 publications

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“…In summary, global clock resetting may be accomplished via hormonal signals, as glucocorticoids can adjust the phase of peripheral circadian clock genes (Balsalobre et al, 2000). Whereas the role of hormones other than glucocorticoids in resetting peripheral oscillators has not been investigated, the marked effects of hormones on circadian function reviewed herein suggest a potentially crucial role for endocrine factors in orchestrating this multioscillatory arrangement.…”

Section: Hormonal and Neural Communication To Glandsmentioning

confidence: 97%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

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Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

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Section: Hormonal and Neural Communication To Glandsmentioning

confidence: 97%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

129

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“…Plasma glucocorticoid concentration is regulated in a rhythmic fashion via the hypothalamus/pituitary/adrenal axis with contribution of the SCN (reviewed in Buijs et al, 2003). The glucocorticoid hormone analog dexamethasone synchronizes the oscillators of cultured cells (Balsalobre et al, 2000). Moreover, injection of dexamethasone alters the phase of clock gene expression in the liver and other peripheral tissues but not in the SCN.…”

Section: Synchronization Of the Liver Oscillator By Systemic Timing Cuesmentioning

confidence: 99%

The role of clock genes and rhythmicity in the liver

Schmutz

Albrecht

Ripperger

2012

Molecular and Cellular Endocrinology

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The liver is the important organ to maintain energy homeostasis of an organism. To achieve this, many biochemical reactions run in this organ in a rhythmic fashion. An elegant way to coordinate the temporal expression of genes for metabolic enzymes relies in the link to the circadian timing system. In this fashion not only a maximum of synchronization is achieved, but also anticipation of daily recurring events is possible. Here we will focus on the input and output pathways of the hepatic circadian oscillator and discuss the recently found flexibility of its circadian transcriptional networks.

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“…It remains unclear how the food-induced entrainment of peripheral clocks functions at the molecular level. Injection of the synthetic glucocorticoid dexamethasone can phase shift clock genes in the liver in a time-dependent manner (Balsalobre et al, 2000). Deletion of the glucocorticoid receptor in the liver, however, does not prevent entrainment of the liver clock after RF (Le Minh=et alK, 2001).…”

Section: Metabolic Control Of Circadian Rhythmsmentioning

confidence: 99%

A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock

Kovac

Husse

Oster

2009

Molecules and Cells

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The cyclic environmental conditions brought about by the 24 h rotation of the earth have allowed the evolution of endogenous circadian clocks that control the temporal alignment of behaviour and physiology, including the uptake and processing of nutrients. Both metabolic and circadian regulatory systems are built upon a complex feedback network connecting centres of the central nervous system and different peripheral tissues. Emerging evidence suggests that circadian clock function is closely linked to metabolic homeostasis and that rhythm disruption can contribute to the development of metabolic disease. At the same time, metabolic processes feed back into the circadian clock, affecting clock gene expression and timing of behaviour. In this review, we summarize the experimental evidence for this bimodal interaction, with a focus on the molecular mechanisms mediating this exchange, and outline the implications for clock-based and metabolic diseases.

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Resetting of Circadian Time in Peripheral Tissues by Glucocorticoid Signaling

Cited by 1,597 publications

References 20 publications

The regulation of neuroendocrine function: Timing is everything

The regulation of neuroendocrine function: Timing is everything

The role of clock genes and rhythmicity in the liver

A Time to Fast, a Time to Feast: The Crosstalk between Metabolism and the Circadian Clock

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