Reserpine, monoamine oxidase inhibitors, and distribution of biogenic amines in monkey brain

Pscheidt, G.R.; Himwich, Harold E.

doi:10.1016/0006-2952(63)90010-8

Cited by 49 publications

(8 citation statements)

References 13 publications

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“…Difficulties arise at the very first step because the carrier-mediated transport system is common to all LNAAs, and transport of 5-HTP and Trp is thus not specific for serotonergic neurons Brown et al, 1979; f Chugani et al, 1998. Brown et al, 1979;‡Pscheidt et al, 1963;§Bucht et al, 1981. (Feldman et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Hagberg

Torstenson

Marteinsdóttir

et al. 2002

J Cereb Blood Flow Metab

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Summary:The substrate for the second enzymatic step in serotonin synthesis, 5-hydroxy-L-tryptophan, labeled in the ␤-position ([ 11 C]-HTP), was used for positron emission tomography (PET) measurements in six healthy human participants, examined on two occasions. One-and two-tissue kinetic compartment modeling of time-radioactivity curves was performed, using arterial, metabolite-corrected [11 C]-HTP values as input function. The availability of unchanged tracer in arterial blood plasma was Ն 80% up to 60 minutes after injection, while [ 11 C]-hydroxyindole acetic acid and [ 11 C]-serotonin accounted for the remaining radioactivity, amounting to Յ16% and Յ4%, respectively. Compartment modeling was performed for brain stem, putamen, caudate nucleus, anterior cingulate, white matter, and superior occipital, occipitotemporal, and temporal cortices. The average biologic half-life for plasma-to-tissue equilibrium was 7 to 12 minutes, and the volume of distribution was 0.2 to 0.5 L·mL

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Section: Discussionmentioning

confidence: 99%

Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Hagberg

Torstenson

Marteinsdóttir

et al. 2002

J Cereb Blood Flow Metab

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“…3 The sparse information on brain epinephrine in the literature suggests that most of it is in the hypothalamus; this monoamine is not included in this table. 4 (Pscheidt, 1963). 5 Only one value of AAAD activity is available for the prefrontal cortex, and is replicated here in two rows.…”

Section: Discussionmentioning

confidence: 99%

Localization of trapping of 6-[18F]fluoro-L-m-tyrosine, an aromaticL-amino acid decarboxylase tracer for PET

Brown

DeJesus

Pyzalski

et al. 1999

Synapse

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The purpose of this study was to address four major questions regarding 6-FMT, a noncatecholic PET tracer for AAAD: 1) Where is the specific uptake of 6-FMT? 2) Why does it accumulate where and to the degree that it does? 3) How does its uptake differ from that of fluoroDOPA globally? and 4) Does its regional uptake differ significantly from that of fluoroDOPA? High-resolution PET scans were obtained in three rhesus monkeys using 6-FMT and in two of them using fluoroDOPA. Anatomic distribution was analyzed visually and quantitative uptake of 6-FMT was compared with published regional decarboxylase activity and monoamine neurotransmitter concentrations. In addition to high uptake in the dopamine-rich striatal nuclei, there was specific uptake of 6-FMT in brain regions which have little dopaminergic innervation but which have other amines in significant concentration. 6-FMT uptake correlated best with regional AAAD activity (r = 0.97). It correlated slightly less well with the sum of catecholamine and indolamine neurotransmitter concentrations, but does not correlate with dopamine concentration. The uptake of 6-FMT is greater than that of fluoroDOPA, with only slight differences in their regional distributions. Radiolabeled analogs of DOPA are often implicitly or explicitly regarded as tracers for presynaptic dopaminergic function. However, localization of these tracers more broadly includes many regions with relatively high concentrations of norepinephrine and serotonin. This may be especially important in diseases or experimental states in which dopaminergic neurons are selectively reduced, and may allow for the study of nondopaminergic neuronal systems in vivo with this tracer.

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“…The marked increase of brain 5-lIT elicited by n. was found in extensive com parative studies (8). A pronounced rise of 5-HT was demonstrated in different brain parts after repeated administration of n. to monkeys (11). A moderate increment of 5-HT in mice brain homo genates 24 h following a large dose of p. was observed (14).…”

Section: Resultsmentioning

confidence: 86%

Monoamine Oxidase Inhibition in the Neurons of Rat Brain Exerted by Nialamide and Pargyline

Bartoníček¹

1966

Pharmacology

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Reserpine, monoamine oxidase inhibitors, and distribution of biogenic amines in monkey brain

Cited by 49 publications

References 13 publications

Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Localization of trapping of 6-[18F]fluoro-L-m-tyrosine, an aromaticL-amino acid decarboxylase tracer for PET

Monoamine Oxidase Inhibition in the Neurons of Rat Brain Exerted by Nialamide and Pargyline

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Reserpine, monoamine oxidase inhibitors, and distribution of biogenic amines in monkey brain

Cited by 49 publications

References 13 publications

Kinetic Compartment Modeling of [11C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Kinetic Compartment Modeling of [11C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Localization of trapping of 6-[18F]fluoro-L-m-tyrosine, an aromaticL-amino acid decarboxylase tracer for PET

Monoamine Oxidase Inhibition in the Neurons of Rat Brain Exerted by Nialamide and Pargyline

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Product

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Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain

Kinetic Compartment Modeling of [¹¹C]-5-Hydroxy-L-Tryptophan for Positron Emission Tomography Assessment of Serotonin Synthesis in Human Brain