Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption

Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos

doi:10.1016/j.bbr.2018.04.011

Cited by 9 publications

(6 citation statements)

References 77 publications

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“…Reserpine is a vesicle reuptake inhibitor, which arrests the neurotransmitters (norepinephrine, epinephrine, dopamine and serotonin) reuptake process on the presynaptic membrane and, therefore, facilitates their further degradation by monoamine oxidase. The depletion of catecholamines (norepinephrine, epinephrine, and dopamine) and serotonin (5-HT) leads to morphological changes in the brain of tested animals and has good face validity due to the appearance of the depression-like phenotype [145][146][147][148]157]. This model is widely used in preclinical studies to evaluate the antidepressant effect of new developing drugs and plant compounds [149][150][151][152][153][154] due to the short-term time and good predictive validity [147,155].…”

Section: Pharmacological Models 431 Reserpine Induced Depression Modelmentioning

confidence: 99%

“…The depletion of catecholamines (norepinephrine, epinephrine, and dopamine) and serotonin (5-HT) leads to morphological changes in the brain of tested animals and has good face validity due to the appearance of the depression-like phenotype [145][146][147][148]157]. This model is widely used in preclinical studies to evaluate the antidepressant effect of new developing drugs and plant compounds [149][150][151][152][153][154] due to the short-term time and good predictive validity [147,155]. However, reserpine treatment produces motor impairments mimicking Parkinson disease dyskinesia, increased nociceptive sensitization and hypothermia and has high mortality rate [148,[155][156][157].…”

Section: Pharmacological Models 431 Reserpine Induced Depression Modelmentioning

confidence: 99%

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Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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Depression is apparently the most common psychiatric disease among the mood disorders affecting about 10% of the adult population. The etiology and pathogenesis of depression are still poorly understood. Hence, as for most human diseases, animal models can help us understand the pathogenesis of depression and, more importantly, may facilitate the search for therapy. In this review we first describe the more common tests used for the evaluation of depressive-like symptoms in rodents. Then we describe different models of depression and discuss their strengths and weaknesses. These models can be divided into several categories: genetic models, models induced by mental acute and chronic stressful situations caused by environmental manipulations (i.e., learned helplessness in rats/mice), models induced by changes in brain neuro-transmitters or by specific brain injuries and models induced by pharmacological tools. In spite of the fact that none of the models completely resembles human depression, most animal models are relevant since they mimic many of the features observed in the human situation and may serve as a powerful tool for the study of the etiology, pathogenesis and treatment of depression, especially since only few patients respond to acute treatment. Relevance increases by the fact that human depression also has different facets and many possible etiologies and therapies.

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Section: Pharmacological Models 431 Reserpine Induced Depression Modelmentioning

confidence: 99%

Section: Pharmacological Models 431 Reserpine Induced Depression Modelmentioning

confidence: 99%

Animal Models of Depression: What Can They Teach Us about the Human Disease?

2021

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“…Recently, it was reported that reserpine-induced depression is associated with heightened, fluoxetine-sensitive, ethanol consumption in female, but not in male, adolescent rats. Thus, this model is currently used to explore the relationship between depression in adolescent females and alcohol consumption [25].…”

Section: Depression Modeling Approachesmentioning

confidence: 99%

Selecting an Appropriate Animal Model of Depression

Hao

Sun

et al. 2019

IJMS

160

112

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Depression has become one of the most severe psychiatric disorders and endangers the health of living beings all over the world. In order to explore the molecular mechanism that underlies depression, different kinds of animal models of depression are used in laboratory experiments. However, a credible and reasonable animal model that is capable of imitating the pathologic mechanism of depression in mankind has yet to be found, resulting in a barrier to further investigation of depression. Nevertheless, it is possible to explain the pathologic mechanism of depression to a great extent by a rational modeling method and behavioral testing. This review aims to provide a reference for researchers by comparing the advantages and disadvantages of some common animal depression models.

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“…In humans, treatment with fluoxetine is effective in reducing symptoms of obsessive-compulsive disorder in adults, adolescents and children [ 85 , 86 , 87 ]. On the other hand, fluoxetine has been demonstrated to be effective in reducing ethanol consumption in female rats [ 88 ] and rats with a high preference for alcohol [ 89 ]. In humans, it has also been effective in reducing alcohol consumption in adults [ 90 ].…”

Section: Discussionmentioning

confidence: 99%

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

Sánchez-Salvador

Prados-Pardo

Martín-González

et al. 2021

IJERPH

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Inhibitory control deficit and impulsivity and compulsivity behaviours are present in different psychopathological disorders such as addiction, obsessive-compulsive disorders and schizophrenia, among others. Social relationships in humans and animals are governed by social organization rules, which modulate inhibitory control and coping strategies against stress. Social stress is associated with compulsive alcohol and drug use, pointing towards a determining factor in an increased vulnerability to inhibitory control deficit. The goal of the present review is to assess the implication of social stress and dominance on the vulnerability to develop impulsive and/or compulsive spectrum disorders, with the aid of the information provided by animal models. A systematic search strategy was carried out on the PubMed and Web of Science databases, and the most relevant information was structured in the text and tables. A total of 34 studies were recruited in the qualitative synthesis. The results show the role of social stress and dominance in increased drug and alcohol use, aggressive and impulsive behaviour. Moreover, the revised studies support the role of Dopaminergic (DA) activity and the alterations in the dopaminergic D1/D2 receptors as key factors in the development of inhibitory control deficit by social stress.

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Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption

Cited by 9 publications

References 77 publications

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Animal Models of Depression: What Can They Teach Us about the Human Disease?

Selecting an Appropriate Animal Model of Depression

The Role of Social Stress in the Development of Inhibitory Control Deficit: A Systematic Review in Preclinical Models

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