Reserpine in the Treatment of Hypertension

Wilkins, Robert W.; Judson, Walter E.; Stone, Richard E.; Hollander, William; Huckabee, William E.; Friedman, Irwin

doi:10.1056/nejm195403182501107

Cited by 34 publications

(2 citation statements)

References 4 publications

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“…Not specified (50) See comments (8) 0 (20) Reserpine (15) Rauwolfia (26) The 67% with "true" depression meet current criteria comparison of 89 hypertensive patients on a variety of medications, and a control group of medically ill but not hypertensive patients [24] found a "high" prevalence of depression in both groups, by interview, but no preponderance in the hypertensive group. There was a higher level of depression in the hypertensive group with a personal or family history of psychiatric illness.…”

Section: Smirk and Mcqueen [S]mentioning

confidence: 94%

Critical Review of Data Supporting Affective Disorder Caused by Nonpsychotropic Medication

Long¹,

Kathol²

1993

Ann. of Clinical Psychiatry

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Since the first reports of depressions associated with the use of reserpine, reports of affective syndromes related to the use of medications have proliferated in the literature. We chose to review controlled and uncontrolled studies, comprehensive reviews with comparisons of controlled studies, and case reports where sheer numbers indicated a relationship existed between affective syndromes and nonpsychotropic medications. Our findings suggest a relationship between the use of reserpine or lipophilic beta-blockers and depressive symptoms, but no clear evidence to support such a relationship with alpha-methyldopa, clonidine, calcium-channel blockers, or ACE-inhibitors. Glucocorticoids are related to both depressive symptoms and mania. Patients on anabolic steroids should be monitored for evidence of mania, rage, depression, and suicidality. There is no clear evidence that oral contraceptives are related to depressive symptoms. Our review does not support a close relationship between the use of H2 blockers, anticonvulsants, levodopa or antiarrhythmics, or antibiotics to affective syndromes.

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Section: Smirk and Mcqueen [S]mentioning

confidence: 94%

Critical Review of Data Supporting Affective Disorder Caused by Nonpsychotropic Medication

Long¹,

Kathol²

1993

Ann. of Clinical Psychiatry

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“…1 It is a crystalline colorless substance which is insoluble in water and moderately soluble in alcohol. Its empirical formula is C33H40O9N2.…”

mentioning

confidence: 99%

Effect in the Newborn Infant of Reserpine Administered ante Partum

BUDNICK¹

1955

Arch Pediatr Adolesc Med

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Reserpine is a pharmacologically active alkaloid derivative prepared from the roots of Rauwolfia serpetina, a small shrub growing wild in certain regions of India and other tropical countries.1It is a crystalline colorless substance which is insoluble in water and moderately soluble in alcohol. Its empirical formula is C33H40O9N2. This drug has several varied pharmacological effects.2 These consist of hypotension, bradycardia, hypothermia, increase in gastrointestinal motility, myosis, and general tranquilization.3Because of its effect in lowering blood pressure, it is used in certain hypertensive states by itself and in combination with other Some of the undesirable effects of this drug in the human are mental depression,5 diarrhea, and weight gain. Headache, dizziness, and nausea are also reported.1 Nasal stuffiness or "congestion" in varying percentages has been noted by several authors.\s=d\ This may be relieved by topical vasoconstrictors and antihistaminics. In the pediatric age group experience with reserpine has been limited. During the month of June, 1954, several newborn infants in our nursery were noted to have nasal discharge shortly after birth.Because of the age of onset, afebrile course, and lack of symptoms in the mothers it was felt that an infectious process was unlikely, and an investigation was made to determine if possible the etiologic agent. We therefore investigated all cases of nasal discharge oc¬ curring during the following three-month period. During that time reserpine, hydralizine (Apresoline) and cryptenamine were being used by the department of obstetrics for the treatment of hypertension associated with toxemia of pregnancy. Meperidine (Demerol) and vinbarbital (Delvinal) were used for their analgesic effects ; chlorpromazine and the barbiturates were employed for sedation, and acetazoleamide (Diamox) was used to reduce edema. The above an¬ algesic agents had been used for a con¬ siderable period of time by the obstetrical department and had never produced nasal discharge. Furthermore no such reactions have been noted from hydralazine, cryp-* References 1-3.t References 1, 6, and 7. Downloaded From: http://archpedi.jamanetwork.com/ by a University of Michigan User on 06/17/2015

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Drug Therapy (Rauwolfia) of Hypertension

Moyer¹

1955

AMA Arch Intern Med

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Reserpine in the Treatment of Hypertension

Cited by 34 publications

References 4 publications

Critical Review of Data Supporting Affective Disorder Caused by Nonpsychotropic Medication

Critical Review of Data Supporting Affective Disorder Caused by Nonpsychotropic Medication

Effect in the Newborn Infant of Reserpine Administered ante Partum

Drug Therapy (Rauwolfia) of Hypertension

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