Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans

Srivastava, Deepti; Arya, Upasna; Rajan, Thangavelu Soundara; Dwivedi, Hemalata; Kumar, Sandeep; Subramaniam, Jamuna R.

doi:10.1007/s10522-008-9139-5

Cited by 55 publications

(47 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[74] In another study by Saharia et al, reserpine efficacy in the treatment of AD was evaluated. [75] They reported that AChE is responsible for increasing the reserpine mediated lifespan [76] and reduction in Aβ toxicity. [75] In Caenorhabditis elegans (an established model of AD), Aβ toxicity causes paralysis [75] [68] 1975 The patent covers rescinnamine-like compounds and a process for producing the same.…”

Section: R Serpentina and Neurodegenerative Diseases (Ndd)mentioning

confidence: 99%

Untitled

Singh

2017

IJGP

View full text Add to dashboard Cite

Rauwolfia serpentina is reported in an Ayurvedic medicinal system for centuries, for the treatment of various ailments such as snakebites, insomnia, hypertension, and insanity. Scientific evaluation of these documents can be valuable for finding new potential use in neurological disorders. The work presents the brief overview of R. serpentina including a description of the plant, its active chemical constituents and pharmacological properties with the major emphasis on cardiovascular and central nervous system disorders. This review compiles information available in the scientific literature from databases such as Science Direct, PubMed, India bioscience. org, Herbs -Medicinal plant usage and Identification Database, Database on medicinal plants used in Ayurveda and Siddha, Missouri Botanical Garden, National Medicinal Plants Board, and the International Plant Names Index. Information gathered from the literature has shown that the alkaloids are the major constituents of the plant imparting various pharmacological properties. Reserpine, the Indole alkaloid, is the most active compound of R. serpentine. The plant is known to possess antidiarrheal, antimicrobial activity apart from using it for the treatment of circulatory disorders, rheumatism, hypertension, insanity, epilepsy, and leaves are used in the removal of opacities of the cornea. Research shows that R. serpentine is a potential source of compounds pertaining medicinal applications. It provides an interesting subject in the search for new drugs of natural origin.

show abstract

Section: R Serpentina and Neurodegenerative Diseases (Ndd)mentioning

confidence: 99%

Untitled

Singh

2017

IJGP

View full text Add to dashboard Cite

show abstract

“…Reserpine irreversibly binds to the storage vesicles of neurotransmitters, particularly norepinephrine, serotonin, and dopamine [105]. Resperine is used as a sedative and hypnotic for reducing blood pressure [106]. It shows antipsychotic and antihypertensive activity and has been used for the control of high blood pressure and for the relief of psychotic symptoms [106].…”

Section: Reserpinementioning

confidence: 99%

“…Resperine is used as a sedative and hypnotic for reducing blood pressure [106]. It shows antipsychotic and antihypertensive activity and has been used for the control of high blood pressure and for the relief of psychotic symptoms [106]. Reserperine treatment from embryo to young adult stage extended lifespan in C.elegans significantly [106].…”

Section: Reserpinementioning

confidence: 99%

“…It shows antipsychotic and antihypertensive activity and has been used for the control of high blood pressure and for the relief of psychotic symptoms [106]. Reserperine treatment from embryo to young adult stage extended lifespan in C.elegans significantly [106]. As Reserpine is a FDA approved drug for hypertension it can be evaluated for lifespan extension in higher model organisms like mice and finally humans [106].…”

Section: Reserpinementioning

confidence: 99%

See 1 more Smart Citation

Bioactive phytomolecules and aging in Caenorhabditis elegans

2015

Healthy Aging Res

View full text Add to dashboard Cite

Aging is a complex phenomenon, a sum total of changes that occur in a living organism with the passage of time and leads to decreasing ability to survive stress, increasing functional impairment and growing probability of death. Aging changes can be attributed to development, genetic defects, environmental factors, disease and an innate process-the aging process. Aging has been one of the most crucial menace factors for a number of socioeconomic burdens, hence discovery of any new chemical that modulates aging in research model organisms could lead to a new strategy for working upon age related diseases like diabetes, cancer and neuro-degenerative disorders. The present review highlights the previous studies suggesting effective modulation of the life prolonging mechanistic pathways and lifespan by various phytomolecules. The free living nematode Caenorhabditis elegans is a well established multicellular model organism for aging in biological research, being used by different laboratories worldwide. The enormous characteristics of this animal model that has contributed to its success includes its genetic pliability, invariant and fully described developmental program, well characterized genome, ease of maintenance, short and fertile life cycle and small body size. Being a multicellular organism it goes through a complex developmental process, including embryogenesis, morphogenesis to grow into an adult so, any biological information from C. elegans may be directly linked with more complex organisms, such as human. The reports on life span extension on exposure to plant based compounds clearly depicts that aging can be slowed down and thus makes life span extension an interesting area for research. This review summarizes the current understanding on interaction of phytomolecules with signalling pathways of aging that provides potential application in human health improvement and development of antiaging therapeutics.

show abstract

“…With this model, we then tested 11 compounds reported to increase lifespan in C. elegans for whether they could suppress the progressive paralysis caused by mutant TDP-43 (mTDP-43). The compounds tested included: the antioxidants propyl gallate (PG), trolox (TRO), and a-lipoic acid (Benedetti et al, 2008), the polyphenols resveratrol (RSV) (Morselli et al, 2010) and quercetin (Kampkotter et al, 2008), the anticonvulsant ethosuximide (ETX) , reserpine (RSP) (Srivastava et al, 2008), spermidine (Eisenberg et al, 2009), valproic acid (Evason et al, 2008, and thioflavin (Alavez et al, 2011), and rolipram (ROL), a Phosphodiesterase 4 inhibitor that mimics the effects of RSV on mitochondrial function and glucose tolerance (Park et al, 2012) (please see Supplementary Table 1 for official names and suppliers). Interestingly, only 6 compounds rescued TDP-43 toxicity: RSV, ROL, RSP, TRO, PG, and ETX (Fig.…”

Section: Neuroprotection From Select Longevity-enhancing Compoundsmentioning

confidence: 99%

Chemical Genetic Screens for TDP-43 Modifiers and ALS Drug Discovery

Drapeau¹,

Parker²,

Kabashi³

et al. 2015

View full text Add to dashboard Cite

Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information , 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. REPORT DATE March 2015 REPORT TYPE PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) AND ADDRESS(ES) PERFORMING ORGANIZATION REPORT NUMBERUniversite de Montreal, L' 2900 Boul. Edouard-Montpetit Montreal H3T 1J4 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTES ABSTRACTOur objective was to screen libraries of several thousand compounds, including clinically approved drugs, for their ability to suppress the in vivo phenotypes observed in worm and fish models expressing mutant human TDP-43 related to ALS and validating hits in a mouse model. Our hypothesis was that chemical modifiers of TDP-43 in vivo function would provide new therapeutic approaches to ALS. Our screen of 3,750 FDA-approved compounds identified 20 active compounds, most of which were neuroleptics with the most potent being pimozide, as well as WithaferinA. In addition to the 4k FDA compounds, we screened 2k molecules that are structurally related to the neuroleptics as well as novel molecules. Also, we screened 4k novel derivatives of pimozide and identified several dozen active compounds. WithaferinA and pimozide were tested in TDP-43 and SOD1 mice. Results suggest that the beneficial effect of Withaferin A in mutant SOD1 mice may be due in part to an upregulation of heat shock proteins (Hsp27 and Hsp70) and to reduction in levels of misfolded SOD1 species. Motor behaviors were not significantly improved or possibly worsened by chronic treatment with pimozide. In addition, the spinal cord and brain of mice revealed and increase in TDP-43 aggregation, but no change in microgliosis, was noted. Neuromuscular transmission was improved acutely. Pimozide is being tested in an ALS clinical trial based on our neuromuscular biomarker. References……………………………………………………………………………. 18 SUBJECT TERMSAppendices INTRODUCTIONOur project was to screen libraries of small chemicals, including clinically approved drugs, for their ability to suppres...

show abstract

Reserpine can confer stress tolerance and lifespan extension in the nematode C. elegans

Cited by 55 publications

References 36 publications

Untitled

Untitled

Bioactive phytomolecules and aging in Caenorhabditis elegans

Chemical Genetic Screens for TDP-43 Modifiers and ALS Drug Discovery

Contact Info

Product

Resources

About