Resection outcomes for primary and local recurrent retroperitoneal liposarcoma patients

Yan, Yang; Du, Xiaohui; Xia, Shaoyou; Li, Songyan; Teng, Da; Hu, Shidong; Wang, Yufeng; Li, Rong

doi:10.21203/rs.3.rs-18897/v1

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Our findings are not unexpected, because a larger tumor would be more likely to involve a larger number of organs and large blood vessels, which would increase the risk of intraoperative blood loss. Because blood loss is independently associated with overall survival in patients with dedifferentiated RPLS (50,51), tumor size >15 cm could be a risk factor for surgical risk in patients with first recurrence of RPLS.…”

Section: Discussionmentioning

confidence: 99%

Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study

Liu¹,

Zou²,

Tang³

et al. 2022

Ann Transl Med

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Background: Surgery is the main treatment for recurrent retroperitoneal liposarcoma (RPLS). The aim of the present study was to explore the factors associated with blood loss during surgery for recurrent RPLS.Methods: This retrospective study included patients with first recurrence of RPLS who were treated at our hospital between January 2015 and December 2019. Factors associated with intraoperative blood loss were identified by univariate and multivariate logistic regression analyses. Receiver-operating characteristic (ROC) curve analyses were conducted to evaluate whether tumor size and number of tumor-containing abdominal/ pelvic zones were predictive of the need for blood transfusion. Results:The study included 67 cases. The number of zones containing tumors was 1 in 4 cases (6%), 2 in 36 cases (53.7%), 3 in 14 cases (20.9%), and 4 in 13 cases (19.4%). Tumor size was associated with blood loss >500 mL

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Section: Discussionmentioning

confidence: 99%

Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study

Liu¹,

Zou²,

Tang³

et al. 2022

Ann Transl Med

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“…El liposarcoma retroperitoneal primario plantea un desafío diagnóstico respecto del comportamiento clínico infrecuente, variado e inespecífico, el mejor tratamiento planteado para evitar recidivas, con pronóstico y predicción favorables para el paciente. Debido a la baja incidencia general de esta enfermedad y la variabilidad entre pacientes, se han realizado pocas investigaciones en la población asiática e inglesa (7).…”

Section: Discussionunclassified

Masas retroperitoneales gigantes: informe de caso

Peñuela

Salamanca²,

Peñuela³

et al. 2022

Med.

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Los tumores retroperitoneales primarios son tumores benignos o malignos, sólidos o quísticos; se consideran una patología infrecuente a nivel mundial, sobre todo en Latinoamérica donde existe poca evidencia científica, con un espectro clínico variado e inespecífico. Estos sarcomas de partes blandas implican <1 % de todos los tumores, siendo el liposarcoma un 20 % de los sarcomas del adulto, de los cuales una tercera parte se forman en el retroperitoneo. Los liposarcomas representan para el cirujano un reto diagnóstico, terapéutico, diverso e interesante. La incidencia anual en Estados Unidos se encuentra cerca de 2,6 x 1.000.000. Por su profunda localización y crecimiento lento, su cuadro clínico es proteiforme y su diagnóstico difícil. Caso clínico: El objetivo de este estudio es presentar un caso de tumor retroperitoneal de gran tamaño, analizando clínica de presentación, pruebas diagnósticas utilizadas, anatomía patológica tumoral, datos quirúrgicos y posibles tratamientos oncológicos y quirúrgicos complementarios. Resultados: Posterior a la cirugía se encuentra masa tumoral vascularizada de apariencia grasa de 40 x 30 cm de diámetro y 7,6 kg de peso. Conclusión: Se hará un aporte al conocimiento que facilite la evaluación al enfrentar casos similares. Los liposarcomas son los tumores de tejido blando más frecuentes en los adultos; por su crecimiento lento, poca sintomatología, tipo histológico y ubicación, se considera todo un reto diagnóstico y de tratamiento.

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“…Surgery is an important treatment of retroperitoneal liposarcoma. Complete resection of the tumor reaching negative margins (R0 resection) is critical for long-term survival [4]. Liposarcoma derives mainly from mesenchymal tissue in retroperitoneal space, which is usually very large at the time of diagnosis.…”

Section: Introductionmentioning

confidence: 99%

The prognostic value of 18F-FDG PET/CT in postoperative recurrence of retroperitoneal liposarcoma: a single center retrospective study

Shi,

Lang,

Liu

et al. 2022

Preprint

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Purpose: Recurrence is the main cause of tumor-related death of retroperitoneal liposarcoma (RPLPS). Different recurrence pattern was determined by variant subtype of retroperitoneal liposarcoma which displayed diverse presentations on 2-[18F]-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT). This study aims to analyze the characteristics of different histologic subtypes of RPLPS on 18F-FDG PET/CT and their associations with recurrence and prognosis.Methods: Clinical-pathological information, 18F-FDG PET/CT, recurrence and progression free survivals (PFS) of 83 patients with RPLPS were collected. Maximum, and peak standardized uptake value (SUVmax and SUVpeak, respectively) and mean CT value (CTmean) of tumors were measured; their correlations with histologic subtype were analyzed. The predictability of SUVmax and CTmean for histologic subtype was evaluated using the receiver operating characteristics (ROC) curve analysis. ROC curve was also performed to analyze the predictive value of SUVmax and peak SUV (SUVpeak) for recurrence. The Kaplan-Meier analysis was performed to analyze whether SUVmax and SUVpeak were risk factors for recurrence. Results: Regarding the histology, 30.1% patients were well-differentiated liposarcoma (WDLPS), 56.6% patients were dedifferentiated liposarcoma (DDLPS), 12.0% patients were myxoid/round cell liposarcoma(MLPS), and 1.2% patients were pleomorphic liposarcoma (PMLPS). SUVmax of DDLPS were significantly higher than those of WDLPS (P < 0.001) and MLPS(P = 0.001). CTmean of WDLPS was significantly lower than those of MLPS (P = 0.001) and DDLPS (P < 0.001). ROC curve suggested 5.1 as an approximate cutoff value of SUVmax for distinguishing DDLPS from non-DDLPS (sensitivity = 76.8%, specificity = 88.0%), and 12.3Hu as cutoff value of CTmean for distinguishing WDLPS from non-WDLPS (sensitivitty = 94.1%, specificity = 54.5%). When the cut-off values of SUVmax and SUVpeak were set at 10.7 and 6.9 respectively, the maximum performances for predicting recurrence were obtained. Kaplan-Meier analyses showed that histologic subtype, SUVmax, and SUVpeak were risk factors that associated with recurrence-free survival (P = 0.02, ＜0.001, and 0.001, respectively).Conclusions: The SUV value and CT features on 18F-FDG PET/CT imaging may increase the confidence in diagnosis and subtype distinguish of RPLPS. When inflammatory liposarcoma was excluded, patients with SUVmax > 10.7 or SUVpeak > 6.9 suggest a poor prognosis.

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Resection outcomes for primary and local recurrent retroperitoneal liposarcoma patients

Cited by 4 publications

References 15 publications

Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study

Prediction of intraoperative bleeding and blood transfusion in patients with recurrent retroperitoneal liposarcoma: a retrospective study

Masas retroperitoneales gigantes: informe de caso

The prognostic value of 18F-FDG PET/CT in postoperative recurrence of retroperitoneal liposarcoma: a single center retrospective study

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