Resection of the Primary Tumor in Stage IV Colorectal Cancer

Feo, Leandro; Polcino, Michael; Nash, Garrett M.

doi:10.1016/j.suc.2017.01.012

Cited by 52 publications

(42 citation statements)

References 59 publications

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“…What's more, systemic chemotherapy, molecular targeted therapy, immunotherapy, portal vein or hepatic artery embolization and radiofrequency ablation play a gradually more important role in mCC treatment, which might provide a potentially longer survival and downstaging of tumor [5,23,27,28]. This situation causes that surgery occupies a gradual weakening trend in CLM treatment, and many studies support the view that surgery would bring more trauma, stress and immunosuppression for CLM patients and probably prompt tumor growth, recurrence and wouldn't bring survival bene t [24,[29][30][31][32][33]. However, there are also some studies stated clearly that resection primary colon cancer or liver metastasis associated with improved survival, and suggested a more aggressive method for the incurable diseases [23,[34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…Surgery type of primary lesion is also a most debated issue for M-CLM, the most often types are partial colectomy and hemicolectomy or greater. Some surgeons tend to choose the partial colectomy cause M-CLM is a terminal stage and surgery couldn't improve survival even bring poor prognosis [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

“…Although the mortality of whole CC is declining, the 5-year survival rate of metastatic CC (mCC) is still miserable and less than 10% [3]. Liver is the most frequent target organ for mCC, and liver metastasis (LM) occurs in up to 25% of stage IV patients [4]. Complete resection of primary tumor and metastatic lesion for some highly-selected resectable colon cancer liver metastasis (CLM) patients is advocated by guidelines and provides better survival than non-surgical treatment, but this part of patients are less than 20% [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Huang

Chen

Liu

et al. 2020

Preprint

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Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed.Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM.Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the long-term survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a better choice than hemicolectomy for M-CLM according to the results from this study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Huang

Chen

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Moreover, systemic chemotherapy, molecular targeted therapy, immunotherapy, portal vein or hepatic artery embolization and radiofrequency ablation have been playing an increasingly more important role in mCC treatment and might provide a potentially longer survival and tumour downstaging [5,23,27,28]. This situation has resulted in surgery being less frequently used as treatment for CLM, and many studies support the view that surgery would bring more trauma, stress and immunosuppression for CLM patients than other treatments, probably prompt tumour growth, and recurrence and would not bring survival bene ts [24,[29][30][31][32][33]. However, some studies clearly state that resection of the primary colon cancer or liver metastasis is associated with improved survival, and suggested a more aggressive method for treating incurable diseases [23,[34][35][36].…”

Section: Discussionmentioning

confidence: 99%

“…Although the mortality of all CCs is declining, the 5-year survival rate of metastatic CC (mCC) is still miserable and less than 10% [3]. The liver is the most frequent target organ for mCC, with liver metastasis (LMs) occurring in up to 25% of stage IV patients [4]. Complete resection of the primary tumours and metastatic lesions for some highly selected resectable colon cancer liver metastasis (CLM) patients is advocated by guidelines and provides better survival than non-surgical treatment, but less than 20% of this population meets the criteria for the procedures [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Huang

Chen

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Mucinous adenocarcinoma (MC) is the second most common pathological type of colon carcinoma (CC). Colon cancer liver metastases (CLMs) are common and lethal, and complete resection of the primary tumour and metastases for CLM patients would be beneficial. However, there is still no consensus on the role of surgery for MC with liver metastases (M-CLM). Methods: Patients diagnosed with M-CLM or classical adenocarcinoma with CLM (A-CLM) from 2010 to 2013 in the Surveillance, Epidemiology, and End Results (SEER) database were retrieved. The clinicopathological features and overall survival (OS) and cancer-specific survival (CSS) data were compared and analysed. Results: The results showed that the M-CLM group had a larger tumour size, more right colon localizations, higher pT and pN stages, more female patients, and more retrieved and positive lymph nodes and accounted for a higher proportion of surgeries than the A-CLM group. The OS and CSS of M-CLM patients who underwent any type of surgery were significantly better than those of patients who did not undergo any surgery, but poorer than those of A-CLM patients who underwent surgery. Meanwhile, the OS and CSS of M-CLM and A-CLM patients who did not undergo any surgery were comparable. Compared with hemicolectomy, partial colectomy led to similar or better OS and CSS for M-CLM, and surgery was an independent protective factor for long-term survival in M-CLM. Conclusions: M-CLM had distinct clinicopathological characteristics from A-CLM, and surgery could improve the long-term survival and is an independent favourable prognostic factor for M-CLM. In addition, partial colectomy might be a non-inferiority choice as hemicolectomy for M-CLM according to the results from this study.

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Impact of anatomic site of distant metastasis on survival in salivary gland cancers

et al. 2021

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Background As exemplified in patients with adenoid cystic carcinoma (ACC), metastatic salivary gland cancers display heterogenous behavior. Although anatomic site of metastasis has been suggested to be prognostic for survival in this population, this is not adequately characterized in the current literature. Methods Using the National Cancer Database (NCDB), patients with newly diagnosed metastatic salivary gland cancers with distant metastasis to a single organ were identified. Results Eight hundred and fifty‐eight patients (n = 284 bone‐only, n = 322 lung‐only, n = 252 other‐site‐only) were identified. Anatomic site of distant metastasis was not associated with survival in the cohort as a whole; however, on pre‐planned subgroup analysis, lung‐only metastasis, relative to bone‐only metastasis, was the only factor associated with improved survival in patients with ACC (HR: 0.52, 95%CI: 0.30–0.93, p = 0.029). Conclusions Anatomic site of metastasis is strongly associated with survival in patients with metastatic ACC and should be considered in future studies aiming to optimize therapy in this population.

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Resection of the Primary Tumor in Stage IV Colorectal Cancer

Cited by 52 publications

References 59 publications

Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Surgery improves the prognosis of colon mucinous adenocarcinoma with liver metastases: A SEER-Based Study

Impact of anatomic site of distant metastasis on survival in salivary gland cancers

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