Resection of Primary Schwannoma of the Liver Not Associated With Neurofibromatosis

Abstract

A 38-year-old woman developed right upper quadrant pain due to a mass in the left lobe of the liver. The tumor was resected along with segment 3 of the left lobe. Histologic examination and immunochemistry supported a diagnosis of benign schwannoma. No metastatic disease was present, and the patient has been well for more than 18 months after surgery without recurrence. This is the first reported case of successful resection of a schwannoma of the liver in a patient without von Recklinghausen's disease.

Hepatic schwannoma: A case report and an updated 40-year review of the literature yielding 30 cases

“…By contrast, the Antoni B area is a loose myxoid structure with a few sparse cells. The proportion of the two components can shift gradually or change suddenly (7). Cystic degeneration, including calcification or hemorrhage, is often recognized in the Antoni B area, which may result from vascular thrombosis and subsequent necrosis.…”

Primary hepatic schwannoma: A case report

“…Although a schwannoma may arise from any organ that contains peripheral nerves, primary hepatic schwannomas are extremely rare. According to English medical literature, only 19 cases of hepatic schwannoma, including the presently reported case, have been documented (Table 1) [3], [4], [5], [6], [7], [8], [9], [10], [11], [12], [13], [14], [15], [16], [17], [18]. These 19 cases consisted of 9 men (47.1%) and 10 women (52.9%), with a median age of 56 years (range, 21–83 years).…”

Malignant Peripheral Nerve Sheath Tumor of the Liver: A Case Report

“…[9] was analyzed with a fairly large panel of immunohistochemistry but the diagnosis of malignant schwannoma was "based" on "scattered S100 protein positivity of tumor cells", there was no ultrastructural examination and the patient had no sign of neurofibromatosis. Other nerve sheath tumors without von Recklinghausen's disease were benign [10][11][12]. The only well documented cases of primary hepatic MPNSTs were schwannomas that underwent malignant transformation [13,14].…”