Resection of hepatic metastases from colorectal carcinoma

Asbun, Horacio J.; Tsao, Jane I.; Hughes, Kevin S.

doi:10.1007/978-1-4615-2604-9_4

Cited by 13 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…55,99 Currently, many institutions recommend surgery if a metastasis can be resected with sufficient remaining liver reserve regardless of the number or the size of the lesions. 4,55,100,101 Newer recommendations define as unresectable tumor as involving more than 70% of the liver or involvement of greater than 6 segments. [102][103][104] Bilobar disease was initially reported to be an absolute contraindication to resection.…”

Section: -Characterization Of Results Of Resection Of Hepatic Metastasesmentioning

confidence: 99%

Resection of Colorectal Liver Metastases: Current Perspectives

2006

View full text Add to dashboard Cite

patients) developed liver metastases, and 30% (44,000 patients) had metastatic disease confined to the liver. In the past, only 5% of patients who developed liver metastases from colorectal cancer were considered eligible for surgical directed therapies. 3 With improved surgical techniques, reduced postoperative mortality, and better systemic therapy, indications for surgery have broadened so that nearly one third of patients with colorectal liver metastases (14,000 patients) undergo hepatic tumor resections each year in the United States. 4-6 Outcomes of Liver Metastasis Resection Historically, liver tumor resection from the liver was associated with a high operative mortality rate. In 1898, Keen et al 7 reported a 15.5% operative mortality rate for liver resection performed in 59 cases from 1886 to 1897.

show abstract

Section: -Characterization Of Results Of Resection Of Hepatic Metastasesmentioning

confidence: 99%

Resection of Colorectal Liver Metastases: Current Perspectives

2006

View full text Add to dashboard Cite

show abstract

“…The liver is the most common site for metastatic colorectal cancer. It was reported that approximately 40% of advanced colorectal cancer patients developed liver metastases [3] , [4] . In 1942, Lisa et al [5] reported that the cirrhotic liver was not a favorable soil for metastatic tumor cells.…”

Section: Introductionmentioning

confidence: 99%

Patients with Chronically Diseased Livers Have Lower Incidence of Colorectal Liver Metastases: A Meta-Analysis

et al. 2014

View full text Add to dashboard Cite

Background70 years ago, it was put forward that the diseased liver was not a favorable soil for metastatic tumor cells. In addition, a few studies have demonstrated that rare occurrence of colorectal liver metastases among patients with fatty liver, cirrhosis or chronic hepatitis B and C virus infection. We performed a meta-analysis to verify the association between the incidences of colorectal liver metastases with chronically diseased livers.MethodsRelevant studies were identified by a search of electronic database PubMed, Cochrane Library, OVID, Web of Science and CNKI (up to February 24, 2014). Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using random- or fixed-effect models when appropriate. Meta-analysis and publication bias (Bgger's test) was evaluated with STATA 12.0.ResultsA total of 10,349 colorectal cancer patients from 10 studies were included. The meta-analysis result showed there was a significant difference in the incidences of colorectal liver metastases between patients with normal and chronically diseased livers (OR = 0.32; 95% CI 95%: 0.26–0.38, P = 0.000 fixed-effects model). The result of Begg's test (Pr>|z| = 0.089; P>0.05) revealed no publication bias.ConclusionsThe results of this meta-analysis demonstrated that patients with chronically diseased livers had significantly lower incidences of colorectal liver metastases than those with normal livers.

show abstract

“…The liver is the most common location of colorectal cancer metastasis. The occurrence of liver metastases in patients with advanced colorectal cancer is about 35% to 40% [ 4 ]. It is estimated that more than half of CRC patients have liver metastases at autopsy [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis

et al. 2021

View full text Add to dashboard Cite

The paper aims to assess the association between Hepatitis B Virus infection and colorectal liver metastasis by conducting a meta-analysis. The relevant studies were searched until 24 July 2020, Studies that assessed the correlation between HBV infection and CRLM were recruited. A random effects model was applied to calculate the odds ratio (OR) with 95% confidence interval (CI). All data analyses were performed by STATA 12.0 software. Ten studies involving 17529 participants were included in the study. The results shown that there was obvious association between HBV infection and CRLM (OR: 0.51, 95% CI: 0.28-0.91). The study type and case-control rate may be the main causes of heterogeneity. In addition, HBV infection had no association with extrahepatic metastasis or prognosis of patients with CRLM. Sensitivity analyses confirmed that the results were stable, and Egg's test indicated that there was no publication bias. Patients with HBV infection have the reduced risk of CRLM.

show abstract

Resection of hepatic metastases from colorectal carcinoma

Cited by 13 publications

References 16 publications

Resection of Colorectal Liver Metastases: Current Perspectives

Resection of Colorectal Liver Metastases: Current Perspectives

Patients with Chronically Diseased Livers Have Lower Incidence of Colorectal Liver Metastases: A Meta-Analysis

Association between hepatitis B virus infection and colorectal liver metastasis: a meta-analysis

Contact Info

Product

Resources

About