Resection of Head of Pancreas and Duodenum for Carcinoma--Pancreatoduodenectomy

Brunschwig, Alexander

doi:10.3322/canjclin.24.6.363

Cited by 32 publications

(27 citation statements)

References 4 publications

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“…During his career, Whipple performed 37 pancreaticoduodenectomies, with the procedure evolving into a one-stage technique [8,9], and 1964-1968 1969-1973 1974-1978 1979-1983 1984-1988 1989-1993 1994-1998 1999-2003 2004-2008 2009-2013 Period of diagnosis Whipple is generally credited with popularizing the operation that still bears his name. In 1937, Alexander Brunschwig performed the first successful pancreaticoduodenectomy for pancreatic adenocarcinoma [10]. Today, with the concentration of experience in high-volume hospitals, pancreatic surgery has become a safe procedure associated with an operative mortality below 3% [11][12][13].…”

Section: Historical Remarks and Present Statementioning

confidence: 99%

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Pancreatic Cancer: Yesterday, Today and Tomorrow

et al. 2016

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Pancreatic cancer is one of our most lethal malignancies. Despite substantial improvements in the survival rates for other major cancer forms, pancreatic cancer survival rates have remained relatively unchanged since the 1960s. Pancreatic cancer is usually detected at an advanced stage and most treatment regimens are ineffective, contributing to the poor overall prognosis. Herein, we review the current understanding of pancreatic cancer, focusing on central aspects of disease management from radiology, surgery and pathology to oncology. Historical remarks & present stateThe first known description of pancreatic cancer is attributed to Giovanni Battista Morgagni in his 1761 publication 'de Sedibus Et Causis Morborum Per Anatomen Indagatis Libri Quinque' [1]. However, the lack of a microscopic evaluation makes the true diagnosis of ductal adenocarcinoma uncertain. The next important advancement in our understanding of pancreatic cancer did not come until 1858, when Jacob Mendez Da Costa revisited Morgagni's original work and also described the first microscopic diagnosis of adenocarcinoma, manifesting pancreatic cancer as a true disease entity [2].The history of pancreatic surgery is fairly recent and involves a combination of brave surgical pioneers, the development of surgical anesthesia and modern aseptic techniques. Some landmarks in the history of pancreatic surgery deserve to be mentioned. The first reported attempt at a pancreaticoduodenectomy was performed in 1898 by the Italian surgeon Alessandro Codivilla for a tumor involving the head of the pancreas [3]; however, the patient did not survive the postoperative period. In the same year, William Stewart Halsted from Johns Hopkins Hospital performed the first successful resection for ampullary cancer by excising portions of the duodenum and the pancreas [4]. The first successful pancreaticoduodenectomy is credited to the German surgeon Walther Carl Eduard Kausch, as part of a two-stage procedure [5]. In 1914, Georg Hirschel performed the first successful pancreaticoduodenectomy in one stage [6] and then in 1935, Allen Oldfather Whipple presented the results of a two-stage procedure involving the resection of the head of the pancreas and duodenum for ampullary carcinoma at the annual meeting of the American Surgical Association, which renewed interest in pancreatic surgery [7]. During his career, Whipple performed 37 pancreaticoduodenectomies, with the procedure evolving into a one-stage technique [8,9], and 1964-1968 1969-1973 1974-1978 1979-1983 1984-1988 1989-1993 1994-1998 1999-2003 2004-2008 2009-2013 Period of diagnosis Whipple is generally credited with popularizing the operation that still bears his name. In 1937, Alexander Brunschwig performed the first successful pancreaticoduodenectomy for pancreatic adenocarcinoma [10]. Today, with the concentration of experience in high-volume hospitals, pancreatic surgery has become a safe procedure associated with an operative mortality below 3% [11][12][13]. While major advances have been made ...

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Section: Historical Remarks and Present Statementioning

confidence: 99%

“…In 1937, Alexander Brunschwig performed the first successful pancreaticoduodenectomy for pancreatic adenocarcinoma [10]. Today, with the concentration of experience in high-volume hospitals, pancreatic surgery has become a safe procedure associated with an operative mortality below 3% [11][12][13].…”

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confidence: 99%

Pancreatic Cancer: Yesterday, Today and Tomorrow

et al. 2016

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“…3 However, even at high volume centers, the current reported morbidity and mortality of pancreatic resection are approximately 35-51% and 1-6%, respectively. [4][5][6] Despite continuous improvements in perioperative mortality and adjuvant chemotherapy, pancreatic adenocarcinoma continues to carry a dismal prognosis.…”

Section: Introductionmentioning

confidence: 99%

Pancreatic Adenocarcinoma: The Actual 5-Year Survivors

Ferrone

Brennan

Gönen

et al. 2008

Journal of Gastrointestinal Surgery

224

147

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“…Obliteration of the pancreatic ductal system with tissue adhe sive might offer a solution to this distressing problem. The method is actually a modification of ductal ligation which is used in pancreatoduo denectomy (2,12) and in pancreatic transplantation (3). Ligation is com patible with life (1, 2, 5, 10, 12), it does not interfere significantly with the endocrine function of the pancreas (1,3,5) and does not increase malab sorption in comparison to pancreatoduodenectomy (5).…”

Section: Discussionmentioning

confidence: 99%

Prevention of Postoperative Pancreatic Fistulae by Intraductal Injection of a Tissue-Adhesive Polymer

Papachristou¹,

D²,

Fortner³

1980

Eur Surg Res

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Ligation of the intact horizontal segment of the pancreas in 8 dogs caused enlargement and then atrophy of the gland. Ligation of dissected pancreases in 9 dogs caused pseudocysts, fistulae and pancreatic ascites in 6. Ligation following obliteration of the ductal system with cyanoacrylate tissue adhesive in 8 dissected pancreases caused no pancreatic complications. Both ligation and obliteration reduced the glucose consumption coefficient (k-value) below the preoperative levels (p < 0.01), there was no difference, however, between the two methods as far as glucose consumption is concerned. Ductal obliteration might prevent the development of pancreatic fistulae following the Whipple procedure offering an alternative to either simple ligation or pancreatojejunostomy.

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Resection of Head of Pancreas and Duodenum for Carcinoma--Pancreatoduodenectomy

Cited by 32 publications

References 4 publications

Pancreatic Cancer: Yesterday, Today and Tomorrow

Pancreatic Cancer: Yesterday, Today and Tomorrow

Pancreatic Adenocarcinoma: The Actual 5-Year Survivors

Prevention of Postoperative Pancreatic Fistulae by Intraductal Injection of a Tissue-Adhesive Polymer

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