Resection of abdominal aortic aneurysms

Thompson, Bernard W.; Meek, Gary N.; Hara, Masauki

doi:10.1016/0002-9610(68)90347-4

Cited by 8 publications

(5 citation statements)

References 9 publications

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“…48 Secondly, this model does not depend on the presence of atherosclerosis, intrinsic defects in structural matrix proteins or hypertension, each of which has been implicated in at least some forms of human AAAs, and elastase-induced aneurysms in rodents only rarely undergo spontaneous rupture. 1 Despite these reservations, the elastaseinduced model has been useful to examine biological mechanisms underlying AAAs because the inciting injury does not result in immediate destruction of medial elastic fibers or …”

Section: Discussionmentioning

confidence: 99%

“…1 Tissues from human and experimental AAAs exhibit chronic transmural inflammation, medial smooth muscle cell depletion and destruction of extracellular matrix proteins, and overproduction of matrix metalloproteinases (MMPs), plasminogen activators, and cathepsins is thought to contribute to this process. [2][3][4][5][6][7][8] Although pharmacologic strategies that use antiinflammatory agents and proteinase inhibitors may have promise in the management of small asymptomatic AAAs, the molecular mechanisms that influence aneurysmal degeneration remain to be defined.…”

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confidence: 99%

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Experimental Abdominal Aortic Aneurysms in Mice Lacking Expression of Inducible Nitric Oxide Synthase

Lee

Borhani

Ennis

et al. 2001

ATVB

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Abstract-To determine if nitric oxide synthase (NOS) contributes to the pathophysiology of abdominal aortic aneurysms (AAAs), C57BL/6J mice underwent transient aortic injury to induce a chronic inflammatory response. Wild-type mice developed a significant increase in aortic diameter within 14 days of elastase perfusion (115Ϯ16%, 40% incidence of AAAs), along with intense and widespread staining for nitrotyrosine, mononuclear inflammation, and delayed destruction of the elastic lamellae. Expression of both endothelial and neuronal forms of NOS was substantially decreased within AAAs, whereas inducible NOS (iNOS) mRNA was increased 360%, and the enzyme was localized to infiltrating inflammatory cells. By using mice with targeted deletion of iNOS to evaluate the functional importance of this enzyme, male iNOS -/-mice developed the same extent of aneurysmal dilatation as congenic controls (121Ϯ22%, 40% incidence of AAAs) and exhibited similar structural features except for diminished nitrotyrosine staining. Aneurysmal dilatation was actually enhanced in female iNOS -/-mice (141Ϯ16%, 80% incidence of AAAs; PϽ0.05), but this effect was reversed by previous oophorectomy. Although extensive protein nitration and increased expression of iNOS accompany the development of elastase-induced experimental AAAs, iNOS is not required in this process and its absence may be deleterious.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Experimental Abdominal Aortic Aneurysms in Mice Lacking Expression of Inducible Nitric Oxide Synthase

Lee

Borhani

Ennis

et al. 2001

ATVB

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“…2 Infusion of osmotic diuretics such as mannitol (9) or plasma expanders (2) which promote urine flow. 3 Avoidance of hypotension especially at the time of declamping of the aorta (2).…”

Section: Discussionmentioning

confidence: 99%

“…2 Infusion of osmotic diuretics such as mannitol (9) or plasma expanders (2) which promote urine flow. 3 Avoidance of hypotension especially at the time of declamping of the aorta (2). Gamulin (1) demonstrated that the renal haemodynamic alterations during infrarenal aortic cross clamping persisted for at least 1 hour after the release of the aortic clamp.…”

Section: Discussionmentioning

confidence: 99%

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Effect of Dopamine on Renal Function during Aortic Cross-Clamping

et al. 1986

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haemodynamics (1-3). Occlusion of the aorta below the renal arteries gives rise to a 75% increase in the renal vascular resistance and 38% decrease in the renal blood flow (1). Mean arterial plasma renin activity was found to rise during anaesthesia for surgery of the abdominal aorta and to rise further after removal of the cross clamp (4). Dopamine infusion in normal subjects, at a rate of 2 to 10 ,tg/kg body wt/min increases the renal blood flow, and increases the glomerular filtration rate and excretion of sodium (5). In anaesthetised patients also, dopamine infusion increased the renal blood flow (6). A study was therefore undertaken to investigate the effect of dopamine upon renal function and plasma renin activity during the period of cross clamping.

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