Resection for Secondary Malignancy of the Pancreas

Hung, Jui Hsia; Wang, Shin E.; Shyr, Yi Ming; Su, Cheng Hsi; Chen, Tien Hua; Wu, Chew Wun

doi:10.1097/mpa.0b013e31821fc8f2

Cited by 29 publications

(39 citation statements)

References 84 publications

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“…RCC, accounting for 3% of all malignancies in adults and 85% of primary renal tumors, has a great propensity to develop synchronous or metachronous metastasis to various anatomic sites [1, 40]. Moreover, late and solitary metastasis have been a unique clinical presentation for RCC after nephrectromy [13]. …”

Section: Discussionmentioning

confidence: 99%

“…Majority (72%) were solitary gallbladder metastasis without other site metastasis at the time of diagnosis. The unique clinical entity of solitary and late metachronous metastasis seems to be observed not only in other organs such as pancreas [13] but also in gallbladder. Although the median tumor size was 2.6 cm, most (70%) of the patients remained asymptomatic at the time of diagnosis and/or follow-up of primary RCC.…”

Section: Discussionmentioning

confidence: 99%

“…Patients with distant metastasis from RCC usually present a poor prognosis, with a 5-year survival rate of <10%. Nevertheless, it is well-known that complete resection of metastasis could have long-term survival in selected patients with pancreas metastasis of RCC [13]. This favorable prognosis might also be the case for those with gallbladder metastasis [11].…”

Section: Introductionmentioning

confidence: 99%

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Metastatic polyp of the gallbladder from renal cell carcinoma

et al. 2017

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BackgroundGallbladder metastasis from renal cell carcinoma (RCC) is extremely rare. The purpose of this study is to clarify the characteristics of metastatic RCC to gallbladder.MethodsThe pooled data for analysis were collected from the case of metastatic RCC to gallbladder encountered by our institution along with sporadic cases reported in literature from 1991 to 2015.ResultsA total of 50 cases of metastatic RCC to gallbladder were recruited for study. Fifty-seven percentage of the primary RCC was from the right kidney and 43% from the left. The median interval between diagnoses of primary and metastatic RCC to gallbladder was 36 months, with the longest duration up to 324 months. Most (70%) were asymptomatic. The size of metastatic RCC to gallbladder ranged from 0.8 cm to 9 cm, with median of 2.6 cm. Majority (91%) of the metastatic RCCs presented as a polypoid mass with narrow stalk, and 82% were hypervascular lesion. The overall 1 year, 3 year and 5 year survival rate was 91.5%, 76.2% and 59.3% respectively, with a median of 26.5 months. Number of the metastatic site, timing of gallbladder metastasis, symptom, tumor size and operation type of cholecystectomy seemed to have no impact on survival.ConclusionsMetastatic RCC to the gallbladder should be taken into account for a gallbladder polypoid mass with narrow hypervascular stalk during the diagnosis and/or follow-up of primary RCC. Gallbladder metastasis from RCC is not necessarily to be an advanced stage with poor outcome, and cholecystectomy is recommended whenever possible.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metastatic polyp of the gallbladder from renal cell carcinoma

et al. 2017

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“…No relationship has been found between the location within the pancreas and the primary RCC. There are also speculations about the reasons why isolated pancreatic metastases from RCC are relatively frequent in the absence of metastases to other organs, one of them being special biology of RCC, another being some unexplained tissue features or special cytokines, tissue factors or genes that make the pancreas a good recipient of metastatic RCC [7,11]. Having so many doubts about RCC metastasizing to the pancreas, it seems even more mysterious why this unpredictable tumor has metastasized to a preexisting pancreatic NET.…”

Section: Discussionmentioning

confidence: 99%

Renal cell carcinoma metastasizing to pancreatic neuroendocrine neoplasm – the second case described in the world literature

Bednarek-Rajewska¹,

Zalewski²,

Breborowicz³

et al. 2017

pjp

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Tumor-to-tumor metastases are very rare events. We report a case of a 64-year-old man who presented with a tumor of the pancreas. The patient underwent partial pancreatectomy. Frozen section diagnosis of the tumor was an endocrine neoplasm. Paraffin block slide examination revealed a tumor consisting of two components: pancreatic endocrine neoplasm at the periphery of the tumor and the central part composed of clear cells with delicate vessels. The results of immunohistochemical stains revealed renal cell carcinoma surrounded by pancreatic endocrine neoplasm, therefore representing an unusual case of renal cell carcinoma metastasizing to a pancreatic endocrine neoplasm.Key words: tumor-to-tumor metastasis, renal cell carcinoma metastasizing to pancreatic endocrine neoplasm.

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“…However, in some cases of locoregional recurrence, if complete resection of the recurrent lesion is performed, the patients' survival may be prolonged [4]. Metastatic pancreatic tumors are relatively rare, with an incidence of 2-4.5% in all pancreatic tumors [5]. Most of them are hematogenous metastases of renal cell carcinoma [6].…”

Section: Discussionmentioning

confidence: 99%

Recurrence of gastric cancer invading the main pancreatic duct: A case report

Maekawa¹,

Orita²,

Sakurada³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Case Report: A 76-years-old female was admitted to our hospital because of abnormality of the pancreas without symptoms. She had been treated with distal gastrectomy due to locally advanced gastric cancer 24 months before admission. Computed tomography scan showed a swelling in the pancreatic body containing a low-density area. MRI scan revealed that the lowdensity area of the central pancreas was the main pancreatic duct dilated and filled with a tumor. IJCRI publishesResection of the gastric remnant with distal pancreatectomy and splenectomy were performed under a diagnosis of a primary pancreatic tumor or gastric cancer recurrence. Pathological examination revealed that a tubular adenocarcinoma packed the main pancreatic duct, and the same neoplasm infiltrating the pancreatic parenchyma was also found. Finally, we diagnosed the lesion as the lymphatic recurrence of gastric cancer. The patient had survived for 12 months since metastasectomy without signs of recurrence. Conclusion:Recurrence of gastric cancer sometimes invades to pancreatic parenchyma and mimics the intraductal pancreatic neoplasm. If the complete resection of locoregional recurrence of gastric cancer is performed, surgical treatment will contribute to prolonging the survival.

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Resection for Secondary Malignancy of the Pancreas

Abstract: Pancreatic resection should not be precluded for secondary malignancy of the pancreas because long-term survival could be achieved with acceptable surgical risk in selected patients.

Cited by 29 publications

References 84 publications

Metastatic polyp of the gallbladder from renal cell carcinoma

Metastatic polyp of the gallbladder from renal cell carcinoma

Renal cell carcinoma metastasizing to pancreatic neuroendocrine neoplasm – the second case described in the world literature

Recurrence of gastric cancer invading the main pancreatic duct: A case report

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