Resectable gallbladder cancer presenting with acute pancreatitis caused by hemobilia

Inoue, Kotaro; Doi, Yasuro; Imai, Katsunori; Takata, Noboru; Yoshinaka, Ichiro; Harada, Kazunori

doi:10.1007/s12328-011-0251-8

Cited by 3 publications

(3 citation statements)

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“…However, the patient is now over 24 months out from her necrotizing pancreatitis and cholecystectomy and has not demonstrated any signs or symptoms of recurrent pancreatitis or biliary pathology to suggest such diagnoses. Related literature searches revealed hemobilia associated with gallbladder cancer as a cause of acute pancreatitis with gall-bladder cancer [5,9]. This was also less likely in our case due to the lack of not only sludge and gallstones, but also coagulated blood when the specimen was opened.…”

Section: Discussionmentioning

confidence: 62%

“…Some patients with cholelithiasis and gallbladder adenocarcinoma present with gallstone ileus or choledocholithiasis [3], but it is felt that these complications are associated with the cholelithiasis and not the neoplasm itself. In addition, gallbladder cancer has been associated with acute pancreatitis in patients with pancreaticobiliary maljunction, but the underlying cause in these patients was likely the anatomic abnormality of the main pancreatic duct [5]. A case report out of Japan described gallbladder cancer associated with hemobilia causing acute pancreatitis [5].…”

Section: Introductionmentioning

confidence: 99%

“…In addition, gallbladder cancer has been associated with acute pancreatitis in patients with pancreaticobiliary maljunction, but the underlying cause in these patients was likely the anatomic abnormality of the main pancreatic duct [5]. A case report out of Japan described gallbladder cancer associated with hemobilia causing acute pancreatitis [5]. We describe a patient who presented with acute necrotizing pancreatitis, without cholelithiasis or other risk factors, and was found to have a fragmented polypoid gallbladder adenocarcinoma.…”

Section: Introductionmentioning

confidence: 99%

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A Case of Acute Pancreatitis Associated with Early-Stage Adenocarcinoma of the Gallbladder

et al. 2019

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Patient: Female, 55 Final Diagnosis: Gallbladder adenocarcinoma Symptoms: Abdominal pain Medication: — Clinical Procedure: Cholecystectomy • pancreatic necrosectomy Specialty: Surgery Objective: Rare co-existance of disease or pathology Background: Gallstones are a common cause of acute pancreatitis. The proposed mechanism by which choledocholithiasis induces pancreatitis is mechanical obstruction of the ampulla leading to the reflux of bile into the pancreatic duct or edema resulting from a gallstone’s passage. To our knowledge, there are no previously reported cases of gallbladder adenocarcinoma as a potential cause of acute pancreatitis. Herein, we describe a patient who presented with acute necrotizing pancreatitis, without other associated risk factors, who was found to have a fragmented friable polypoid gallbladder adenocarcinoma. Case Report: A 55-year old Hispanic female with prediabetes presented to the Emergency Department with severe epigastric abdominal pain radiating to her back. The patient’s clinical presentation, laboratory tests and computed tomography imaging were suggestive of acute necrotizing pancreatitis and a gallbladder lesion concerning for neoplasm. After clinical resolution of her pancreatitis, the patient was brought to the operating room for a cholecystectomy. Final pathology revealed a stage T1aN0 gallbladder adenocarcinoma. Conclusions: We have presented a patient with acute necrotizing pancreatitis in the absence of alcohol abuse, gallstones, biliary sludge, hypertriglyceridemia, hypercalcemia, or hereditary predisposition. Without evidence of other etiologies, we hypothesize that the friable tumor fragments of the gallbladder adenocarcinoma might be the underlying cause of pancreatitis in this patient.

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Section: Discussionmentioning

confidence: 62%