Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design

Gross, Rachel S.; Thaweethai, Tanayott; Rosenzweig, Erika B.; Chan, James; Chibnik, Lori B.; Cicek, Mine S.; Elliott, Amy J.; Flaherman, Valerie J.; Foulkes, Andrea S.; Witvliet, Margot Gage; Gallagher, Richard; Gennaro, Maria Laura; Jernigan, Terry L.; Karlson, Elizabeth W.; Katz, Stuart D.; Kinser, Patricia A.; Kleinman, Lawrence C.; Lamendola-Essel, Michelle F.; Milner, Joshua D.; Mohandas, Sindhu; Mudumbi, Praveen C.; Newburger, Jane W.; Rhee, Kyung E.; Salisbury, Amy L.; Snowden, Jessica; Stein, Cheryl R.; Stockwell, Melissa S.; Tantisira, Kelan G.; Thomason, Moriah E.; Truong, Dongngan T.; Warburton, David; Wood, John C.; Ahmed, Shifa; Akerlundh, Almary; Alshawabkeh, Akram N.; Anderson, Brett R.; Aschner, Judy L.; Atz, Andrew M.; Aupperle, Robin L.; Baker, Fiona C.; Balaraman, Venkataraman; Banerjee, Dithi; Barch, Deanna M.; Baskin‐Sommers, Arielle; Bhuiyan, Sultana; Bind, Marie-Abèle; Bogie, Amanda; Buchbinder, Natalie C.; Bueler, Elliott; Bükülmez, Hülya; Casey, B. J.; Chang, Linda; Clark, Duncan B.; Clifton, Rebecca G.; Clouser, Katharine N.; Cottrell, Lesley; Cowan, Kelly; D’Sa, Viren; Dapretto, Mirella; Dasgupta, Soham; Dehority, Walter; Dummer, Kirsten; Elias, Matthew D.; Esquenazi-Karonika, Shari; Evans, Danielle N.; Faustino, E. Vincent S.; Fiks, Alexander G.; Forsha, Daniel; Foxe, John J.; Friedman, Naomi P.; Fry, Greta; Gaur, Sunanda; Gee, Dylan G.; Gray, Kevin M.; Harahsheh, Ashraf S.; Heath, Andrew C.; Heitzeg, Mary M.; Hester, Christina M.; Hill, Sophia; Hobart-Porter, Laura; Hong, Travis K.F.; Horowitz, Carol R.; Hsia, Daniel S.; Huentelman, Matthew J.; Hummel, Kathy D.; Iacono, William G.; Irby, Katherine; Jacobus, Joanna; Jacoby, Vanessa L.; Jone, Pei‐Ni; Kaelber, David C.; Kasmarcak, Tyler J.; Kluko, Matthew J.; Kosut, Jessica; Laird, Angela R.; Landeo‐Gutierrez, Jeremy; Lang, Sean M.; Larson, Christine L.; Lim, Peter Paul; Lisdahl, Krista M.; McCrindle, Brian W.; McCulloh, Russell J.; Mendelsohn, Alan L.; Metz, Torri D.; Morgan, Lerraughn M.; Müller‐Oehring, Eva M.; Nahin, Erica R.; Neale, Michael C.; Ness-Cochinwala, Manette; Nolan, Sheila M.; Oliveira, Carlos Rocha; Oster, Matthew E.; Payne, R. Mark; Raissy, Hengameh H.; Randall, Isabelle G.; Rao, Suchitra; Reeder, Harrison T.; Rosas, Johana; Russell, Mark W.; Sabati, Arash; Sanil, Yamuna; Sato, Alice I.; Schechter, Michael S.; Selvarangan, Rangaraj; Shakti, Divya; Sharma, Kavita; Squeglia, Lindsay M.; Stevenson, Michelle D.; Szmuszkovicz, Jacqueline R.; Talavera‐Barber, Maria M.; Teufel, Ronald J.; Thacker, Deepika; Udosen, Mmekom M.; Warner, M.; Watson, Sara E.; Werzberger, Alan; Weyer, Jordan C.; Wood, Marion J.; Yin, H. Shonna; Zempsky, William T.; Zimmerman, Emily; Dreyer, Benard P.

doi:10.1101/2023.04.27.23289228

2023

DOI: 10.1101/2023.04.27.23289228

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Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design

Rachel S. Gross

Tanayott Thaweethai

Erika B. Rosenzweig

et al.

Abstract: Importance: The prevalence, pathophysiology, and long-term outcomes of COVID-19 (post-acute sequelae of SARS-CoV-2 [PASC] or “Long COVID”) in children and young adults remain unknown. Studies must address the urgent need to define PASC, its mechanisms, and potential treatment targets in children and young adults. Observations: We describe the protocol for the Pediatric Observational Cohort Study of the NIH’s REsearching COVID to Enhance Recovery (RECOVER) Initiative. RECOVER-Pediatrics is an observational meta… Show more

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Remote variants of the disappearing lung syndrome as a complication of COVID-19 pneumonia

Lynnyk,

Gumeniuk,

Yakovenko

et al. 2023

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BACKGROUND. The pandemic of the coronavirus disease (COVID-19) associated with the SARS-CoV-2 virus has left many complications, including the pulmonary system. One of them is the syndrome of disappearing lungs. It occurred both in the acute period of the disease and in the post-COVID period (after 3-4 months) after inpatient treatment. Remote variants of the disappearing lung syndrome as a complication of COVID-19 pneumonia have not been studied to date. OBJECTIVE. To study distant variants of the course of the disappearing lung syndrome as one of the complications of nosocomial pneumonia of viral etiology (COVID-19) and to demonstrate it on clinical observations. MATERIALS AND METHODS. The dynamics of computed tomography (CT) data of patients with a complicated course of nosocomial viral pneumonia (COVID-19), who were treated at the SI “National Institute of Phthisiology and Pulmonology named after F.G. Yanovsky of the NAMS of Ukraine”. RESULTS. Remote variants of the course of the disappearing lung syndrome as a complication of COVID-19 pneumonia are the development of bullous or diffuse emphysema of the lungs, giant thin-walled cyst-like cavities, and recurrent pneumothorax and pneumomediastinum. These variants are very diverse, and their results can be different even with identical radiological manifestations. CONCLUSIONS. The most unfavorable variant of the course of the disappearing lung syndrome is the development of recurrent pneumothorax and pneumomediastinum, which requires observation for more than 1.5-2 years and control CT scans of the chest.

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Remote variants of the disappearing lung syndrome as a complication of COVID-19 pneumonia

Lynnyk,

Gumeniuk,

Yakovenko

et al. 2023

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Current issues of post-covid syndrome consequences

Krasnoselskyi,

Starenkyi,

Artamonova

et al. 2023

УРОЖ

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Background. The World Health Organization (WHO) has confirmed the outbreak of covid infection and defined it as a global pandemic. Recently, complications have been increasingly reported in patients who have had COVID-19. At the same time, clinical symptoms of the long-term course of this disease overlap, differing from acute manifestations of the infection, and may persist in recovered patients for several weeks, months or years, adding a number of other problems. Therefore, the importance of a thorough study of the post-COVID-19 syndrome as a modern phenomenon has increased. And this syndrome requires proper research to improve the efficiency of its prevention and treatment. Purpose. To evaluate the current state of the problem of post-COVID-19 syndrome, in particular in cancer patients. Materials and methods. A literature review was performed based on the array of digital publications found in the world databases PubMed, Scopus and Web of Science Core Collection for 2020–2023. The sources were systematized in separate groups, i.e., issues related to post-Covid, in particular, the mechanisms and pathogenesis of its development; treatment features, including cancer patients; long-term consequences in recovered patients, etc. Results and discussion. The terminology on the subject of the study has been analyzed: post-COVID, post-COVID syndrome, PASC, long-COVID, acute COVID, chronic COVID, etc. The views regarding the pathogenesis of post-COVID syndrome and its main symptoms were systematized. It is determined that in the field of oncology, research is conducted in certain fields and the risk of progression and occurrence of cancer in the post-COVID period is evaluated; the efficiency of the process of cancer care organization in the post-COVID period and the level of complications and mortality of cancer patients who have suffered from COVID-19. The pandemic has also led to multiple changes in the field of radiological diagnosis of the consequences of cancer patients with COVID. Evaluating the impact of the pandemic on the outcomes and adaptation of radiotherapy and chemotherapy, it was determined that delays in the provision of timely care and changes in treatment regimens will affect long-term survival of cancer patients. Conclusion. Assessing the current state of the problem of post-COVID syndrome, most researchers believe that cancer progression during delay in cancer care will negatively affect the long-term survival of cancer patients, and coincidence of cancer-related symptoms and symptoms of long-term COVID is another major challenge for oncologists in the future.

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Researching COVID to enhance recovery (RECOVER) pediatric study protocol: Rationale, objectives and design

Cited by 2 publications

References 58 publications

Remote variants of the disappearing lung syndrome as a complication of COVID-19 pneumonia

Remote variants of the disappearing lung syndrome as a complication of COVID-19 pneumonia

Current issues of post-covid syndrome consequences

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