Researches Concerning the Formation of Gall-stones

Rains, A. J. Harding

doi:10.1136/bmj.2.5306.685

Cited by 26 publications

(6 citation statements)

References 14 publications

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“…19 in 1962 had shown the presence of microorganisms in culture of gallstones and similarly Large A. M. 20 in 1963 had also concluded that infection of bile caused change in permeability of gall bladder mucosa leading to cholelithiasis.…”

Section: Resultsmentioning

confidence: 96%

A Microbial Profile of Patients With Cholecystitis and/or Cholelithiasis Undergoing Cholecystectomy Along With Their Antibiogram

Garg¹,

Kumar²,

Parihar³

2016

jemds

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BACKGROUNDBiliary tract disease is common cause of bacteraemia, associated with high morbidity and mortality. Most common infecting organisms are from Enterobacteriaceae family. Complications of bacteraemia are acute renal failure & septic shock. MATERIALS AND METHODSThe study was conducted on 50 cases of cholelithiasis (who were admitted and treated in different units of General Surgery Department) and had undergone open or laparoscopic cholecystectomy. The samples collected were blood or bile, and then Gallstone Culture, Antibiogram Testing, Biochemical test (indole, methyl red, etc.) were performed. RESULTSGallstones disease was more common in females as compared to males (F:M:3.5: 1) and the maximum age incidence was in 41-50 years age group (38%). Pain abdomen was the predominant symptom present in 88% of cases, flatulent dyspepsia in 44% cases and nausea/vomiting in 32% cases, while tenderness in right hypochondrium was present in 44% of cases. Out of total 50 cases, 18 (36%) showed positive bile cultures and incidence of positive cultures increased with advancing age with maximum being positive in 41-60 years age group. Gallstone culture was positive in 28 cases (56%). Most common organism isolated from bile was E. coli (44% of positive cases) followed by Klebsiella (22%) and Pseudomonas (16%). CONCLUSIONSInfection plays a key role in pathogenesis of chronic calculous cholecystitis and bile and gallstone culture is a good method to demonstrate the infective potential of bacteria colonising the gall bladder.

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Section: Resultsmentioning

confidence: 96%

A Microbial Profile of Patients With Cholecystitis and/or Cholelithiasis Undergoing Cholecystectomy Along With Their Antibiogram

Garg¹,

Kumar²,

Parihar³

2016

jemds

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“…Hence this entity has been named as the cystic duct syndrome [1 -3]. On the other hand, bile stasis in the gallbladder has been considered as one of the important lithogenic factors [4][5][6][7][8][9][10][11][12][13][14]. An increase in the cystic duct resistance or its occlusion has been shown to form sludge and eventually stones in the gallbladder [6-8, 13, 15-17].…”

Section: Introductionmentioning

confidence: 99%

Complex Cystic Duct is Associated With Cholelithiasis

Deenitchin

Yoshida²,

Chijiiwa³

et al. 1997

HPB Surgery

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The relationship between complex cystic ducts and cholelithiasis has seldom been investigated quantitatively. Thus we attempted a retrospective survey on two case series with and without cholelithiasis in a university hospital. A total of 500 patients who underwent endoscopic retrograde cholangiography were reviewed, 250 of whom had cholelithiasis and another 250 no gallstones. They were sampled at random during the period from 1979 through 1993. Parameters including the length, inner diameter and configuration of the cystic duct, and the angle formed by the cystic duct, and the axis of the gallbladder were compared between the groups with or without cholelithiasis. The patients with gallstones has significantly (p<0.001) longer and narrower cystic ducts (a mean of 48mm and 4mm in length and diameter, respectively) than did those without stones (a mean of 28mm and 7mm, respectively). Moreover, patients with gallstones showed a significantly (p<0.001) more acute angle between the gallbladder and the cystic duct than those without (a mean angle of 84° and 119° respectively). The overall frequency of the disfigurements of the cystic duct was significantly higher in the group with gallstones (99%) than in the group without (29%). The results therefore suggested that complex cystic ducts are associated with cholelithiasis.

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“…However, among Japanese living in the United States the type and location of stones of the biliary tract are identical with the type and location of such stones in the population in general. 4 Whether dietary factors are of etiologic significance in cholelithiasis is unproved. Lithogenic diets low in cholesterol and fat have been developed for animals.…”

mentioning

confidence: 99%

“…Thorough investigation of the physicochemical characteristics of bile salts, cholesterol and phospholipids is necessary to understand the phenomenon of stone growth. 4 Inflammation probably is of importance in formation of gallstones. Chemical, rather than bacterial, inflammation seems of greater significance in initiating alterations in the function and histologic configuration of the gallbladder.…”

mentioning

confidence: 99%

Cholecystitis in the Elderly Patient

Foulk

1964

Postgraduate Medicine

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Researches Concerning the Formation of Gall-stones

Cited by 26 publications

References 14 publications

A Microbial Profile of Patients With Cholecystitis and/or Cholelithiasis Undergoing Cholecystectomy Along With Their Antibiogram

A Microbial Profile of Patients With Cholecystitis and/or Cholelithiasis Undergoing Cholecystectomy Along With Their Antibiogram

Complex Cystic Duct is Associated With Cholelithiasis

Cholecystitis in the Elderly Patient

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