Research with the stable isotopes of oxygen (O17 and O18) during 1958–1960

Samuel, David; Steckel, F.

doi:10.1016/0020-708x(61)90021-7

Cited by 6 publications

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“…[8] and Samuel & Steckel [9] administered 18 O by inhalation and orally (incorporated in drinking water) to mice and found no biological effect. Administration of 13 C-labelled endogenous substances, such as carbohydrates and lipids, has been widely applied in biochemical studies but to our knowledge never induced intoxication, either when administered as a single oral dose or as a continuous intravenous infusion.…”

Section: Safetymentioning

confidence: 99%

Applications of stable isotopes in clinical pharmacology

Schellekens

Stellaard

Woerdenbag

et al. 2011

Brit J Clinical Pharma

103

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This review aims to present an overview of the application of stable isotope technology in clinical pharmacology. Three main categories of stable isotope technology can be distinguished in clinical pharmacology. Firstly, it is applied in the assessment of drug pharmacology to determine the pharmacokinetic profile or mode of action of a drug substance. Secondly, stable isotopes may be used for the assessment of drug products or drug delivery systems by determination of parameters such as the bioavailability or the release profile. Thirdly, patients may be assessed in relation to patient-specific drug treatment; this concept is often called personalized medicine. In this article, the application of stable isotope technology in the aforementioned three areas is reviewed, with emphasis on developments over the past 25 years. The applications are illustrated with examples from clinical studies in humans.

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Section: Safetymentioning

confidence: 99%

Applications of stable isotopes in clinical pharmacology

Schellekens

Stellaard

Woerdenbag

et al. 2011

Brit J Clinical Pharma

103

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Die stabilen Isotope des Sauerstoffs in Forschung und Technik

Staschewski¹

1974

Angewandte Chemie

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Die stabilen Sauerstoffisotope erweisen sich als leistungsfähige Instrumente der Forschung; die Verwendungsmöglichkeiten dieser Isotope sind jedoch erst zu einem geringen Teil untersucht. Im vorliegenden Fortschrittsbericht werden fünf Grundtypen von Isotopen‐Effekten herausgestellt, deren Untersuchung und Auswertung eine neue Art von Informationen über physikalische, chemische und biologische Systeme und Prozesse liefern.

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The Stable Isotopes of Oxygen in Research and Technical Applications

Staschewski¹

1974

Angew. Chem. Int. Ed. Engl.

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Research with the stable isotopes of oxygen (O17 and O18) during 1958–1960

Cited by 6 publications

References 0 publications

Applications of stable isotopes in clinical pharmacology

Applications of stable isotopes in clinical pharmacology

Die stabilen Isotope des Sauerstoffs in Forschung und Technik

The Stable Isotopes of Oxygen in Research and Technical Applications

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