Research update of adipose tissue-based therapies in regenerative dermatology

Bellei, Barbara; Migliano, Emilia; Picardo, Mauro

doi:10.1007/s12015-022-10328-w

Cited by 9 publications

(5 citation statements)

References 257 publications

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“…In addition to this, ADSCs do not exploit their regenerative and immunomodulatory function only when isolated and subsequently injected but also when transplanted together with other components of the fat tissue. This happens in the setting of lipofilling, nano-or micro-fat grafting and SVF (stromal vascular fraction) transplantation [54]. These procedures enable clinicians to at least partially restore the normal genital anatomy and potentially lead to better cosmetic outcomes, with positive implications in terms of quality of life and patient satisfaction.…”

Section: Adipose-derived Stem Cell (Adsc) Therapymentioning

confidence: 99%

Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

Paganelli,

Contu,

Condorelli

et al. 2023

IJMS

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Lichen sclerosus (LS) is a chronic inflammatory dermatosis mostly localized in the genital area, characterized by vulvar alterations that can severely impact a patient’s quality of life. Current treatment modalities often provide incomplete relief, and there is a need for innovative approaches to manage this condition effectively. Platelet-rich plasma (PRP) and adipose-derived stem cells (ADSCs) have emerged as potential regenerative therapies for LS, offering promising results in clinical practice. This comprehensive review explores the utilization of PRP and ADSC therapy in the treatment of genital LS, highlighting their mechanisms of action, safety profiles, and clinical outcomes. PRP is a blood product enriched in growth factors and cytokines, which promotes tissue regeneration, angiogenesis, and immune modulation. ADSC regenerative potential relies not only in their plasticity but also in the secretion of trophic factors, and modulation of the local immune response. Numerous studies have reported the safety of PRP and ADSC therapy for genital LS. Adverse events are minimal and typically involve mild, self-limiting symptoms, such as transient pain and swelling at the injection site. Long-term safety data are encouraging, with no significant concerns identified in the literature. PRP and ADSC therapy have demonstrated significant improvements in LS-related symptoms, including itching, burning, dyspareunia, and sexual function. Additionally, these therapies enable many patients to discontinue the routine use of topical corticosteroids. Several studies have explored the efficacy of combining PRP and ADSC therapy for LS. In combination, PRP and ADSCs seem to offer a synergistic approach to address the complex pathophysiology of LS, particularly in the early stages. The use of PRP and ADSC therapy for genital lichen sclerosus represents a promising and safe treatment modality. These regenerative approaches have shown significant improvements in LS-related symptoms, tissue trophism, and histological features. Combination therapy, which harnesses the synergistic effects of PRP and ADSCs, is emerging as a preferred option, especially in early-stage LS cases. Further research, including randomized controlled trials and long-term follow-up, is warranted to elucidate the full potential and mechanisms of PRP and ADSC therapy in the management of genital LS. These regenerative approaches hold great promise in enhancing the quality of life of individuals suffering from this challenging condition.

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Section: Adipose-derived Stem Cell (Adsc) Therapymentioning

confidence: 99%

Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

Paganelli,

Contu,

Condorelli

et al. 2023

IJMS

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“…Adult mesenchymal stem cell-based therapy demonstrated effectiveness in some clinical indications for both autologous and allogeneic purposes, thus becoming one of the most promising therapies in the regenerative medicine field, including the dermatologic one [ 167 , 168 , 169 , 170 ]. Blood, bone marrow, and adipose tissue represent important stem cell resources for cell-based therapies [ 171 ].…”

Section: Regenerative Therapies Based On Nonmelanocytic Cellsmentioning

confidence: 99%

“…Platelet-rich plasma (PRP) is a biological product, a portion of a plasma with a platelet concentration above the baseline containing a great source of cytokines, growth factors, and other biologically active substances with a regenerative potential [ 192 ]. Autologous PRP, originally designed for wound healing and dermatological cosmetic problems, has recently received considerable attention for application for several other diseases, especially in the dermatological field [ 167 , 168 , 193 , 194 ]. Side effects of PRP therapy are few, consisting of irritation, pain at the recipient site, infections, and blood clots [ 192 ].…”

Section: Regenerative Therapies Based On Nonmelanocytic Cellsmentioning

confidence: 99%

Regenerative Medicine-Based Treatment for Vitiligo: An Overview

2022

Self Cite

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Vitiligo is a complex disorder with an important effect on the self-esteem and social life of patients. It is the commonest acquired depigmentation disorder characterized by the development of white macules resulting from the selective loss of epidermal melanocytes. The pathophysiology is complex and involves genetic predisposition, environmental factors, oxidative stress, intrinsic metabolic dysfunctions, and abnormal inflammatory/immune responses. Although several therapeutic options have been proposed to stabilize the disease by stopping the depigmentation process and inducing durable repigmentation, no specific cure has yet been defined, and the long-term persistence of repigmentation is unpredictable. Recently, due to the progressive loss of functional melanocytes associated with failure to spontaneously recover pigmentation, several different cell-based and cell-free regenerative approaches have been suggested to treat vitiligo. This review gives an overview of clinical and preclinical evidence for innovative regenerative approaches for vitiligo patients.

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“…Thus, the scarring of the skin will lead to both functionally and aesthetically displeasing outcomes after dermal injury. In search of new treatment modalities to augment skin wound healing and to prevent or reverse dermal scarring, the use of adipose tissue (lipofilling or fat grafting) has become a hot topic of interest, both in daily reconstructive plastic surgery as well as in regenerative medicine research [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. Several clinical studies have reported improved skin quality, faster wound healing, a decrease in functional scar-restrictions, and the alleviation of scar-related pain after fat grafting [ 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 ]…”

Section: Introductionmentioning

confidence: 99%

Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage

et al. 2023

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In recent decades, adipose tissue transplantation has become an essential treatment modality for tissue (volume) restoration and regeneration. The regenerative application of adipose tissue has only recently proven its usefulness; for example, the method is useful in reducing dermal scarring and accelerating skin-wound healing. The therapeutic effect is ascribed to the tissue stromal vascular fraction (tSVF) in adipose tissue. This consists of stromal cells, the trophic factors they secrete and the extracellular matrix (ECM), which have immune-modulating, pro-angiogenic and anti-fibrotic properties. This concise review focused on dermal regeneration using the following adipose-tissue components: adipose-tissue-derived stromal cells (ASCs), their secreted trophic factors (ASCs secretome), and the ECM. The opportunities of using a therapeutically functional scaffold, composed of a decellularized ECM hydrogel loaded with trophic factors of ASCs, to enhance wound healing are explored as well. An ECM-based hydrogel loaded with trophic factors combines all regenerative components of adipose tissue, while averting the possible disadvantages of the therapeutic use of adipose tissue, e.g., the necessity of liposuction procedures with a (small) risk of complications, the impossibility of interpatient use, and the limited storage options.

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Research update of adipose tissue-based therapies in regenerative dermatology

Cited by 9 publications

References 257 publications

Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

Platelet-Rich Plasma (PRP) and Adipose-Derived Stem Cell (ADSC) Therapy in the Treatment of Genital Lichen Sclerosus: A Comprehensive Review

Regenerative Medicine-Based Treatment for Vitiligo: An Overview

Adipose Tissue-Derived Components: From Cells to Tissue Glue to Treat Dermal Damage

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