Research Trends and Most Influential Clinical Studies on Anti-PD1/PDL1 Immunotherapy for Cancers: A Bibliometric Analysis

Liu, Yanhao; Xu, Yan; Cheng, Xi; Lin, Yaru; Jiang, Shu; Yu, Haiming; Zhang, Zhen; Lu, Linlin; Zhang, Xiaotao

doi:10.3389/fimmu.2022.862084

Cited by 23 publications

(26 citation statements)

References 110 publications

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“…Citation analysis is one of the main methods of bibliometrics, which can evaluate the quality and recognition of articles, and better understand the discipline construction and development of a research field. At present, many immunotherapy-related areas have been well researched and explored through bibliometric analysis, such as the analyses of highly cited articles in programmed cell death protein 1 (PD-1) and programmed cell death ligand 1(PD-L1) immunotherapy ( 20 ), immunotherapy for hepatocellular carcinoma ( 21 ) and colorectal cancer ( 22 ), and emerging chimeric antigen receptor-based immunotherapy ( 23 ). However, currently, there is no published paper on the quantitative analysis of interactions between GM and CI.…”

Section: Introductionmentioning

confidence: 99%

Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021)

Yang

Zhao

et al. 2022

Front. Immunol.

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BackgroundThere is a crosstalk between gut microbiota (GM) and cancer immunotherapy (CI). The purpose of this study is to use bibliometric analysis to identify the highly cited papers relating to GM/CI and explore the research status and development trends of the GM/CI research.MethodsA literature search regarding GM/CI publications from 2012 to 2021 was undertaken on July 4, 2022. The article titles, journals, authors, institutions, countries, total citations, keywords, and other information were extracted from the Science Citation Index Expanded (SCIE) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package and VOSviewer were used for bibliometric analysis.ResultsA total of 665 papers were extracted. The number of papers has increased rapidly over the past decade, especially after 2018. The United States and China had the most publications and made great contributions to this field. Th5e Univ Texas MD Anderson Canc Ctr and Univ Paris Saclay were absolutely in the leading position in GM/CI. The most influential authors were Zitvogel L and Routy B. Frontiers in Immunology had the most publications and Science had the most total citations. Historical direct citation analysis explained the historical evolution in GM/CI. Highly cited papers and high-frequency keywords illustrated the current status and trends of GM/CI. Four clusters were identified and the important topics included the role of GM and antibiotics in CI, the methods of targeting GM to improve CI outcomes, the mechanism by which GM affects CI and the application of ICIs in melanoma. “Tumor microbiome”, “proton pump inhibitors” and “prognosis” may be the new focus of attention in the next few years.ConclusionThis study filtered global publications on GM/CI correlation and analyzed their bibliometric characteristics, identified the most cited papers in GM/CI, and gained insight into the status, hotspots and trends of global GM/CI research, which may inform researchers and practitioners of future directions.

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Section: Introductionmentioning

confidence: 99%

Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021)

Yang

Zhao

et al. 2022

Front. Immunol.

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“…The Web of Science (Science Citation Indexing Expanded database) is frequently used for bibliometric analysis. This database includes more than 10,000 high-quality journals and comprehensive citation records ( 6 ). In addition, its document type labels of publications were reported to be more precise than other databases such as Scopus ( 9 ).…”

Section: Methodsmentioning

confidence: 99%

“…As a method for sorting published articles and establishing the citation relationship (ie, bibliographic coupling) between them, a bibliometric analysis can aid researchers to become familiar with the state of a research area ( 6 , 7 ). It is superior to review or meta-analysis in evaluating a whole academic discipline including thousands of publications ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Research landscape and trends of lung cancer radiotherapy: A bibliometric analysis

Liu

Jiang²,

Lin³

et al. 2022

Front. Oncol.

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Backgroundradiotherapy is one of the major treatments for lung cancer and has been a hot research area for years. This bibliometric analysis aims to present the research trends on lung cancer radiotherapy.MethodOn August 31, 2022, the authors identified 9868 articles on lung cancer radiotherapy by the Web of Science (Science Citation Indexing Expanded database) and extracted their general information and the total number of citations. A bibliometric analysis was carried out to present the research landscape, demonstrate the research trends, and determine the most cited papers (top-papers) as well as top-journals on lung cancer radiotherapy. After that, the authors analyzed the recent research hotspots based on the latest publications in top-journals.ResultsThese 9868 papers were cited a total of 268,068 times. “Durvalumab after chemoradiotherapy in stage III non–small-cell lung cancer” published in 2017 by Antonia et al.was the most cited article (2110 citations). Among the journals, New England Journal of Medicine was most influential. Moreover, J. Clin. Oncol. and Int. J. Radiat. Oncol. Biol. Phys. was both influential and productive. Corresponding authors represented the USA (2610 articles) and China mainland (2060 articles) took part in most publications and articles with corresponding authors from Netherlands were most cited (46.12 citations per paper). Chemoradiotherapy was the hottest research area, and stereotactic body radiotherapy has become a research hotspot since 2006. Radiotherapy plus immunotherapy has been highly focused since 2019.ConclusionsThis bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on 9868 relevant articles, and further suggests future research directions. The researchers can benefit in selecting journals and in finding potential collaborators. This study can help researchers gain a comprehensive picture of the research landscape, historical development, and recent hotspots in lung cancer radiotherapy and can provide inspiration for future research.

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“…The main treatments for lung cancer involved surgery, radiotherapy, and chemotherapy. In recent years, immune checkpoint inhibitors (ICIs) and targeted therapy have led to a remarkable improvement in the prognosis of patients with lung cancer ( 2 ). Programmed cell death 1 (PD–1)/PD1 ligand 1 (PD–L1) interaction is the most frequent target for lung cancer immunotherapy.…”

Section: Introductionmentioning

confidence: 99%

Global research landscape and trends of lung cancer immunotherapy: A bibliometric analysis

Liu

Han

et al. 2022

Front. Immunol.

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BackgroundImmunotherapy for lung cancer has been a hot research area for years. This bibliometric analysis aims to present the research trends on lung cancer immunotherapy.MethodOn 1 July, 2022, the authors identified 2,941 papers on lung cancer immunotherapy by the Web of Science and extracted their general information and the total number of citations. A bibliometric analysis was carried out to present the research landscape, demonstrate the research trends, and determine the most cited papers (top papers) as well as major journals on lung cancer immunotherapy. After that, recent research hotspots were analyzed based on the latest publications in major journals.ResultsThese 2,941 papers were cited a total of 122,467 times. “Nivolumab vs. docetaxel in advanced non–squamous non–small–cell lung cancer” published in 2015 by Borghaei H et al. was the most cited paper (5,854 citations). Among the journals, New England Journal of Medicine was most influential. Corresponding authors represented China took part in most articles (904) and papers with corresponding authors from the USA were most cited (139.46 citations per paper). Since 2015, anti–PD–(L)1 has become the hottest research area.ConclusionsThis bibliometric analysis comprehensively and quantitatively presents the research trends and hotspots based on thousands of publications, and further suggests future research directions. Moreover, the results can benefit researchers to select journals and find potential collaborators. This study can help researchers get a comprehensive impression of the research landscape, historical development, and recent hotspots in lung cancer immunotherapy and provide inspiration for further research.

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Research Trends and Most Influential Clinical Studies on Anti-PD1/PDL1 Immunotherapy for Cancers: A Bibliometric Analysis

Cited by 23 publications

References 110 publications

Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021)

Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021)

Research landscape and trends of lung cancer radiotherapy: A bibliometric analysis

Global research landscape and trends of lung cancer immunotherapy: A bibliometric analysis

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