Mini-grants are an increasingly common tool for engaging communities in evidence-based interventions (EBI) for promoting public health. This paper describes efforts by four Centers for Disease Control and Prevention/National Cancer Institute-funded Cancer Prevention and Control Research Networks to design and implement mini-grant programs to disseminate EBIs for cancer prevention and control. This paper describes source of EBI, funding levels, selection criteria, timeframe, number and size of grants, types of organizations funded, selected accomplishments, training and technical assistance (TA), and evaluation topics/methods. Grant size ranged from $1,000–10,000 (median=$6,250). This mini-grant opportunity was characterized by its emphasis on training and TA for evidence-based programming and dissemination of interventions from NCI’s Research Tested Intervention Programs and CDC’s Community Guide. All projects had an evaluation component although they varied in scope. Mini-grant processes described can serve as a model for organizations such as state health departments working to bridge the gap between research and practice.