Research status of vitiligo models

Abstract

Vitiligo is a multifactorial autoimmune disease characterized by depigmentation of the skin and mucous membranes. The etiology and pathogenesis of vitiligo are not yet fully understood. The establishment of suitable vitiligo models will facilitate studies of the pathogenesis and therapeutic treatments of vitiligo. At present, vitiligo models have usually been established by treatment with chemical substances such as monobenzone and hydroquinone, and by the exogenous injection of CD8+ T cells into transgenic mice. Those models have their own advantages and disadvantages, and are suitable for different types of research. In addition to animal models, many drug-induced types of vitiligo have been found clinically, such as vitiligo-like skin lesions caused by some chemotherapy drugs, antiepileptic drugs and antifungal drugs. This article will describe some methods used to establish vitiligo models, to detect biomarkers associated with vitiligo, and will discuss the application of vitiligo models.

Establishment of a promising vitiligo mouse model for pathogenesis and treatment studies

“…But the model construction method is not uniform, and the depigmentation effect is unstable [ 13 ]. Kindl and Zhao et al established the vitiligo model induced by exogenous T cells requires high technical operation, and the depigmentation effect is unstable [ 14 ]. Mukhatayev and Frantz et al established transgenic vitiligo mouse model.…”