Research status of Chinese medicine formula based on network pharmacology

Pan, Zhenghui; Li, Mengqian; Jin, Zhiyu; Sun, Daofeng; Zhang, Danshen; Hu, Beibei; Li, Zhongqiu; Jing, Yongshuai; Sun, Shiguo

doi:10.1016/j.prmcm.2022.100132

Cited by 9 publications

(5 citation statements)

References 174 publications

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“…However, multiple targets, components, and pathways associated with the action mechanism of TCM in disease treatment complicate its development (20). The properties of a Chinese medicinal formula and its mode of action, such as integrity, systematization, and comprehensiveness, are similar to those of network pharmacology (21). The study of the pharmacological mechanisms of Chinese medicines can be wellfitted into pharmacology equations (22).…”

Section: Discussionmentioning

confidence: 99%

Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha

Liao,

Yousif,

Huang

et al. 2023

Front. Endocrinol.

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Herein, network pharmacology was used to identify the active components in Ilex kudingcha and common hypertension-related targets. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were conducted, and molecular docking was performed to verify molecular dynamic simulations. Six active components in Ilex kudingcha were identified; furthermore, 123 target genes common to hypertension were identified. Topological analysis revealed the strongly associated proteins, with RELA, AKT1, JUN, TP53, TNF, and MAPK1 being the predicted targets of the studied traditional Chinese medicine. In addition, GO enrichment analysis revealed significant enrichment of biological processes such as oxidative stress, epithelial cell proliferation, cellular response to chemical stress, response to xenobiotic stimulus, and wound healing. Furthermore, KEGG enrichment analysis revealed that the genes were particularly enriched in lipid and atherosclerosis, fluid shear stress and atherosclerosis, and other pathways. Molecular docking revealed that the key components in Ilex kudingcha exhibited good binding potential to the target genes RELA, AKT1, JUN, TP53, TNF, and IL-6. Our study results suggest that Ilex kudingcha plays a role in hypertension treatment by exerting hypolipidemic, anti-inflammatory, and antioxidant effects and inhibiting the transcription of atherosclerosis-related genes.

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Section: Discussionmentioning

confidence: 99%

Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha

Liao,

Yousif,

Huang

et al. 2023

Front. Endocrinol.

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“…Now, the TCM comprises more than 11,000 documentary herbs which can be categorized based on tastes and four properties, as well as the site of action (Chang, 2016;Xu et al, 2018). The herbal formulation in TCM and the herbs' interaction were studied based on the herbs' taste, properties, site of actions, and seven relations theory (Chang, 2016;Pan et al, 2022).…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

“…Easy diseases such as hypertension have been solved previously. Research today faces the challenges of solving more complicated and difficult diseases such as rare genetic diseases, diseases that involve multi-targets and the increasing cases of antimicrobial resistance as well as the emergence of new and recurring viruses infections (Li et al, 2022;Romano & Tatonetti, 2019;Sun et al, 2022;Triggle, 2007). Besides, diseases associated with ageing such as neurodegenerative disease, cardiovascular diseases, metabolic diseases etc, pose another challenge with the increasing ageing population (Li et al, 2022).…”

Section: Complexity Of the Diseasesmentioning

confidence: 99%

Drug discovery and development: A historical overview, current challenges and perspectives

Yu,

Tham

2024

LSMB

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The evolution of drug discovery has proceeded for decades. The process has involved the invention of new theories, technologies, disciplines and medicines. These advancements play significant roles in drug discovery today as well as in the future. In this review, the important achievements of ancient Egyptian, Greek, Arabic, Indian, and Chinese medicines were discussed. Then, the development of key concepts, theories or technologies as well as breakthroughs in drug discovery research has been reviewed. Lastly, the current outlook and obstacles in drug discovery studies have been discussed in this article. This review provides an understanding of drug discovery research from a historical perspective and current contexts.

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“…This integrative approach, which blends systems biology with computational techniques, offers a holistic understanding of the pharmacological effects of such formulations. [4][5][6] Diabecon, an Ayurvedic multi-component formulation, encapsulates the essence of this paradigm shift in drug discovery. Comprising Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum, Diabecon is renowned for its antidiabetic properties.…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology of Ayurvedic Multicomponent Formulation Diabecon Containing Gymnema sylvestre, Pterocarpus marsupium and Asphaltum punjabinum with Special Reference to Antidiabetic Property

Sable,

Ahire

2024

IJPQA

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Network pharmacology, a burgeoning field amalgamating systems biology and computational biology, offers a promising avenue to unravel the intricate mechanisms of multi-component formulations in traditional medicine systems such as Ayurveda. This paper delves into the network pharmacology analysis of Diabecon, an Ayurvedic formulation comprising Gymnema sylvestre, Pterocarpus marsupium, and Asphaltum punjabinum, with a focus on its antidiabetic properties. Leveraging information from diverse databases and employing tools like Cytoscape, we constructed pharmacological networks elucidating the interactions between bioactive and molecular targets, particularly in the context of diabetes. Our analysis unveils novel insights into the synergistic effects of the constituents of Diabecon, shedding light on their mechanisms of action and potential therapeutic applications in managing diabetes mellitus. This research not only enhances our understanding of the pharmacodynamics of Diabecon but also paves the way for the identification of new therapeutic leads and targets for combating diabetes and related metabolic disorders.

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Research status of Chinese medicine formula based on network pharmacology

Cited by 9 publications

References 174 publications

Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha

Network pharmacology- and molecular docking-based analyses of the antihypertensive mechanism of Ilex kudingcha

Drug discovery and development: A historical overview, current challenges and perspectives

Network Pharmacology of Ayurvedic Multicomponent Formulation Diabecon Containing Gymnema sylvestre, Pterocarpus marsupium and Asphaltum punjabinum with Special Reference to Antidiabetic Property

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