Research status and future prospects of extracellular vesicles in primary Sjögren’s syndrome

Zhao, Jingwen; An, Qi; Zhu, Xueqing; Yang, Baoqi; Gao, Xinnan; Zhang, Liyun; Xu, Ke; Ma, Dan

doi:10.1186/s13287-022-02912-1

Cited by 16 publications

(16 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…pSS is a chronic systemic autoimmune disease characterized by lymphocyte proliferation and progressive exocrine gland damage 22 . Since the onset of dry syndrome is insidious, the clinical manifestations of patients are different, and the severity of the disease also varies greatly, so the early and clear diagnosis of the disease has important clinical significance to improve the prognosis of patients.…”

Section: Discussionmentioning

confidence: 99%

Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren’s syndrome

Chen

et al. 2023

Sci Rep

View full text Add to dashboard Cite

The aim of this study was to explore the feasibility of Raman spectroscopy combined with computer algorithms in the diagnosis of primary Sjögren syndrome (pSS). In this study, Raman spectra of 60 serum samples were acquired from 30 patients with pSS and 30 healthy controls (HCs). The means and standard deviations of the raw spectra of patients with pSS and HCs were calculated. Spectral features were assigned based on the literature. Principal component analysis (PCA) was used to extract the spectral features. Then, a particle swarm optimization (PSO)-support vector machine (SVM) was selected as the method of parameter optimization to rapidly classify patients with pSS and HCs. In this study, the SVM algorithm was used as the classification model, and the radial basis kernel function was selected as the kernel function. In addition, the PSO algorithm was used to establish a model for the parameter optimization method. The training set and test set were randomly divided at a ratio of 7:3. After PCA dimension reduction, the specificity, sensitivity and accuracy of the PSO-SVM model were obtained, and the results were 88.89%, 100% and 94.44%, respectively. This study showed that the combination of Raman spectroscopy and a support vector machine algorithm could be used as an effective pSS diagnosis method with broad application value.

show abstract

Section: Discussionmentioning

confidence: 99%

Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren’s syndrome

Chen

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…In SS patients’ T cells, it was found that exosomes contained a specific miRNA that adversely affects calcium and cAMP pathways, decreasing protein production by salivary epithelial cells. Additionally, exosomes isolated from the tears of SS patients were found to contain more TNF-alpha-related factors and B-cell survival-related proteins [ 130 ].…”

Section: On the Horizon—novel Diagnostic Modalitiesmentioning

confidence: 99%

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

Kulbay

Tănăsescu

et al. 2023

IJMS

View full text Add to dashboard Cite

Sjögren’s syndrome is a chronic and insidious auto-immune disease characterized by lymphocyte infiltration of exocrine glands. The patients typically present with ocular surface diseases related to dry eye and other systemic manifestations. However, due to the high prevalence of dry eye disease and the lack of objective and clinically reliable diagnostic tools, discriminating Sjögren’s syndrome dry eye (SSDE) from non-Sjögren’s syndrome dry eye (NSSDE) remains a challenge for clinicians. Diagnosing SS is important to improve the quality of life of patients through timely referral for systemic workups, as SS is associated with serious systemic complications such as lymphoma and other autoimmune diseases. The purpose of this article is to describe the current molecular understanding of Sjögren’s syndrome and its implications for novel diagnostic modalities on the horizon. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. The SSDE pathophysiology and immunology pathways have become better understood in recent years. Novel diagnostic modalities, such as tear and saliva proteomics as well as exosomal biomarkers, provide hope on the horizon.

show abstract

“…However, MSC administration was found to be limited by donor compatibility and long preparation times of autologous transplants [ 84 ]. In this case, exosomes derived from MSCs have been shown to overcome these difficulties.…”

Section: On the Horizon: Mesenchymal Stem Cells Therapy And Exosomesmentioning

confidence: 99%

“…When transplanted or infused in mice, exosomes derived from MSCs were shown to decrease symptoms of SS and differentiate into different salivary gland cells, resulting in restored function of the glands [ 84 ]. Labial gland derived MSCs and their associated exosomes have been found to rebalance the expression of miRNA-125b-5p and miRNA-155-5p in CD4+ T cells [ 86 , 87 ].…”

Section: On the Horizon: Mesenchymal Stem Cells Therapy And Exosomesmentioning

confidence: 99%

“…Olfactory ecto-MSC derived exosomes secrete IL-6, which could activate the JAK2/STAT pathway of myeloid-derived suppressor cells to significantly improve saliva flow rate and reduce tissue damage in Sjogren’s mice models [ 89 ]. Some studies also observed significant enrichment of miRNA miR-21 by MSC exosomes, which was shown to play a significant role in exosome-related immune regulation [ 84 ]. While MSC-derived exosomes show promise in the treatment of SS dry eyes, further studies need to be conducted to better understand the mechanism of action of exosomes and the manufacturing constraint related to their production.…”

Section: On the Horizon: Mesenchymal Stem Cells Therapy And Exosomesmentioning

confidence: 99%

See 1 more Smart Citation

Management of Sjogren’s Dry Eye Disease—Advances in Ocular Drug Delivery Offering a New Hope

Chen²,

Chu-Bédard³

et al. 2022

Pharmaceutics

View full text Add to dashboard Cite

Sjögren’s syndrome is a chronic and insidious autoimmune disease characterized by lymphocyte infiltration of exocrine glands. Patients typically present with dry eye, dry mouth, and other systemic manifestations. Currently, the available molecules and drug-delivery systems for the treatment of Sjögren’s syndrome dry eye (SSDE) have limited efficacy since they are not specific to SSDE but to dry eye disease (DED) in general. The current treatment modalities are based on a trial-and-error approach using primarily topical agents. However, this approach gives time for the vicious cycle of DED to develop which eventually causes permanent damage to the lacrimal functional unit. Thus, there is a need for more individualized, specific, and effective treatment modalities for SSDE. The purpose of this article is to describe the current conventional SSDE treatment modalities and to expose new advances in ocular drug delivery for treating SSDE. A literature review of the pre-clinical and clinical studies published between 2016 and 2022 was conducted. Our current understanding of SSDE pathophysiology combined with advances in ocular drug delivery and novel therapeutics will allow the translation of innovative molecular therapeutics from the bench to the bedside.

show abstract

Research status and future prospects of extracellular vesicles in primary Sjögren’s syndrome

Cited by 16 publications

References 77 publications

Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren’s syndrome

Raman spectroscopy combined with a support vector machine algorithm as a diagnostic technique for primary Sjögren’s syndrome

An Overview of the Dry Eye Disease in Sjögren’s Syndrome Using Our Current Molecular Understanding

Management of Sjogren’s Dry Eye Disease—Advances in Ocular Drug Delivery Offering a New Hope

Contact Info

Product

Resources

About