Research Progress on Tumor-Associated Macrophages and Inflammation in Cervical Cancer

Liu, Yi; Li, Li; Liu, Ying; Zhao, Xia

doi:10.1155/2020/6842963

Cited by 33 publications

(36 citation statements)

References 68 publications

(64 reference statements)

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“…TAMs type conversion plays a non-negligible role in tumor invasion and metastasis. In the CC microenvironment, the transformation of TAMs belongs to transformation of the immune type, which plays an important role in the prognosis of CC [35]. For the mixed phenotype of macrophages in the microenvironment, recent studies have shown that TAMs have functions similar to those of M2-like macrophages [36].…”

Section: Discussionmentioning

confidence: 99%

The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma

et al. 2021

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Tumor microenvironment (TME) plays a particularly important role in the progression, invasion and metastasis of cervical carcinoma (CC). Tumor-associated macrophages (TAMs) are significant components of the tumor microenvironment in CC. However, the results of studies on the correlation between TAMs and progression in CC are still controversial. This research aimed to investigate the relationship between TAMs infiltration and progression in CC. A total of 100 patients with CC were included in the study. The correlation between TAMs and clinicopathologic features was studied. Besides, a systematic literature search was conducted from legitimate electronic databases to specifically evaluate the role of TAMs in TME of cervical carcinoma. In the meta-analysis, high stromal CD68+ TAMs density was relevant to lymph node metastasis (WMD = 11.89, 95% CI 5.30 to 18.47). At the same time, CD163+ M2 TAM density was associated with lymph node metastasis (OR = 2.42, 95% CI 1.09 to 5.37; WMD = 39.37, 95% CI 28.25 to 50.49) and FIGO stage (WMD = -33.60, 95% CI -45.04 to -22.16). This was further confirmed in the experimental study of 100 tissues of cervical cancer. It supported a critical role of TAMs as a prospective predictor of cervical cancer. In conclusion, CD68+ TAM and CD163+ M2 TAM infiltration in CC were associated with tumor progression. And CD163+ M2 TAM infiltration was associated with more advanced FIGO stage and lymph node metastasis in CC.

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Section: Discussionmentioning

confidence: 99%

The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma

et al. 2021

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“…xed with 10% buffered formalin for (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24) h at RT, then para n-embedded, and sectioned into 4-μmthick sections. The sections were prepared for histologic examination following staining with hematoxylin and eosin (H&E).…”

Section: Pulmonary Metastases Of Osteosarcomamentioning

confidence: 99%

“…The polarization of macrophages have been more recently demonstrated by Low et al [7][8][9][10], wherein, the coculture of nasopharyngeal carcinoma (NPC) cells and macrophages exerted pro-tumoral functions by inducing various in ammatory cytokines during the early stage; however, up-regulated the induction of cancer-related genes in macrophages in the later stages, suggesting that recruited macrophages into the NPC tumor microenvironment was tuned to promote tumor progression. In the gastric cancer tumor microenvironment, crosstalk between tumor cells and TAMs induced the secretion of in ammatory factors including Il-6, TNF-α, and CCL2, via the NF-κB signaling cascade to promote the development of gastric cancer [11][12][13][14]. Besides, the effect of TAMs on tumor progression possibly depends on the tumor type, TME, and the localization of TAMs.…”

Section: Introductionmentioning

confidence: 99%

Tumor-derived Exosomes Induced M2 Macrophage Polarization and Promoted the Metastasis of Osteosarcoma Cells Through Tim-3

Cheng

Wang

et al. 2021

Archives of Medical Research

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Background: Osteosarcomas, the second most prevalent primary malignancy of the bone, are often presented with high-grade subclinical metastatic disease that metastasizes at very early stages. Exosomes, as molecular information carriers, may play a potent role in the occurrence and development of tumors through oncogenic molecular reprogramming of tumor-associated macrophage (TAM). In this study, we will investigate the effect of osteosarcoma-derived exosomes on the polarization of TAM and decipher its underlying molecular mechanism. Material and Methods: Osteosarcoma-derived exosomes from MG63 cells were isolated and characterized by transmission electron microscopy, and nano-particle size analysis. Double uorescence staining was performed to con rm the macrophages phagocytosis of exosomes. Western blot, qRT-PCR, and transwell assays were conducted to assess the effect of exosomes on migration, invasion, and macrophage differentiation. The mouse model of osteosarcoma was established to evaluate the effects of exosomes on lung metastasis in vivo. Results: MG63 exosomes were successfully isolated and veri ed to be phagocytized by macrophages through uorescence confocal microscopy. The results revealed that osteosarcoma cells could induce M2 type differentiation of macrophages largely through Tim-3 mediated by exosomes, which in turn could promote the migration, invasion, EMT, and lung metastasis of osteosarcoma cells through the secretion of cytokines including IL-10, TGFβ, and VEGF. Conclusions: Our results demonstrated that osteosarcoma-derived exosomes induced M2 polarization of macrophages and promoted the invasion and metastasis of tumors through Tim-3; besides, the study also suggests a novel therapeutic target for future studies.

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“…The tumor microenvironment is an important hallmark of cancers, hence a prefect target for safer therapies. In the tumor microenvironment, macrophages play a very important role in carcinogenesis [ 94 ].…”

Section: Cancer Hallmarks Targetable By Innocuous Integrative Oncologymentioning

confidence: 99%

Biological Therapy with Complementary and Alternative Medicine in Innocuous Integrative Oncology: A Case of Cervical Cancer

Chizenga

Abrahamse

2021

Pharmaceutics

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Good medicine is based on good science, inquiry driven and open to new paradigms. For a complex disease such as cancer, a complex treatment regime that is well structured and multifactorial is indispensable. In the present day, Complementary and Alternative Medicine (CAM) therapies are being used frequently for cancer, alongside modern biological therapies and allopathic medicine, in what is called integrative oncology. In all conscience, the use of natural, less invasive interventions whenever possible is ideal. However, a comprehensive understanding of not only the etiopathology of individual cancers, but also the detailed genetic and epigenetic characteristics, the cancer hallmarks, that clearly show the blueprint of the cancer phenotype is a requisite. Different tumors have a common behavioral pattern, but their specific features at the genetic and epigenetic levels vary to a great extent. Henceforth, with so many failed attempts to therapy, drug formulations and combinations need a focused pre-assessment of the inherent features of individual cancers to destroy the tumors holistically by targeting these features. This review therefore presents innocuous therapeutic regimes by means of CAM and integrative medicine approaches that can specifically target the hallmarks of cancer, using the case of cervical cancer.

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Research Progress on Tumor-Associated Macrophages and Inflammation in Cervical Cancer

Cited by 33 publications

References 68 publications

The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma

The correlation between tumor-associated macrophage infiltration and progression in cervical carcinoma

Tumor-derived Exosomes Induced M2 Macrophage Polarization and Promoted the Metastasis of Osteosarcoma Cells Through Tim-3

Biological Therapy with Complementary and Alternative Medicine in Innocuous Integrative Oncology: A Case of Cervical Cancer

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