Research progress on the treatment of epilepsy with traditional Chinese medicine

Wu, Jie; Cao, Mayijie; Peng, Ying; Dong, Biao; Jiang, Yunxiu; Hu, C.; Zhu, Ping; Xing, Wen; Yu, Lingying; Xu, Rui‐hua; Chen, Zhimin

doi:10.1016/j.phymed.2023.155022

Cited by 15 publications

(8 citation statements)

References 69 publications

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“…However, current antiseizure drugs are limited in terms of their low e cacy and severe side effects. TCM has attracted attention owing to its widespread use in traditional and folk medicine for the treatment and prevention of epilepsy (Lin and Hsieh, 2021;Wu et al, 2023). The main nding of the present study was that pretreatment with NRICM101, a TCM formula, has anticonvulsant effects on KA-induced seizures in rats that are accompanied by signi cant attenuation of KA-induced neuronal loss, astrocytosis, increased glutamate, in ammatory molecules (HMGB1, NF-kB, IL-1β, IL-6, and TNF-α) and necroptotic markers (RIPK-3 and MLKL) in the cortex and hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Taiwan Chingguan Yihau (NRICM101) prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system

Hung,

Chiu,

Chen

et al. 2024

Preprint

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Taiwan Chingguan Yihau (NRICM101) is a Traditional Chinese medicine (TCM) formula used to treat coronavirus disease 2019; however, its impact on epilepsy has not been revealed. Therefore, the present study evaluated the anti-epileptogenic effect of orally administered NRICM101 on kainic acid (KA)-induced seizures in rats and investigated its possible mechanisms of action. Sprague‒Dawley rats were administered NRICM101 (300 mg/kg) by oral gavage for 7 consecutive days before receiving an intraperitoneal injection of KA (15 mg/kg). NRICM101 considerably reduced the seizure behavior and electroencephalographic seizures induced by KA in rats. NRICM101 also significantly decreased the neuronal loss and glutamate increase and increased GLAST, GLT-1, GAD67, GDH and GS levels in the cortex and hippocampus of KA-treated rats. In addition, NRICM101 significantly suppressed astrogliosis (as determined by decreased GFAP expression); neuroinflammatory signaling (as determined by reduced HMGB1, TLR-4, IL-1β, IL-1R, IL-6, p-JAK2, p-STAT3, TNF-α, TNFR1 and p-IκB levels, and increased cytosolic p65-NFκB levels); and necroptosis (as determined by decreased p-RIPK3 and p-MLKL levels) in the cortex and hippocampus of KA-treated rats. The effects of NRICM101 were similar to those of carbamazepine, a well-recognized antiseizure drug. Furthermore, no toxic effects of NRICM101 on the liver and kidney were observed in NRICM101-treated rats. The results indicate that NRICM101 has antiepileptogenic and neuroprotective effects through the suppression of the inflammatory cues (HMGB1/TLR4, Il-1β/IL-1R1, IL-6/p-JAK2/p-STAT3, and TNF-α/TNFR1/NF-κB) and necroptosis signaling pathways (TNF-α/TNFR1/RIP3/MLKL) associated with glutamate level regulation in the brain and is innocuous. Our findings highlight the promising role of NRICM101 in the management of epilepsy.

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Section: Discussionmentioning

confidence: 99%

Taiwan Chingguan Yihau (NRICM101) prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system

Hung,

Chiu,

Chen

et al. 2024

Preprint

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“…These saponins exhibit significant variance in structure and properties, depending on their source. Furthermore, steroidal saponins from different species of the same plant can display distinct pharmacological activities [ 14 ].…”

Section: Discussionmentioning

confidence: 99%

“…It is caused by abnormal discharges of groups of neurons, mainly due to an imbalance between excitatory and inhibitory neural transmission [ 13 ]. Traditional Chinese medicine has been found to have significant efficacy in treating epilepsy, with lower toxicity and fewer side effects, providing a significant advantage over conventional treatments [ 14 ]. Recent investigations have indicated that the methanol extract of water eggplant, employed as an anti-epileptic and antispasmodic medication in traditional Philippine medicine, contains steroidal saponins, which exhibit anticonvulsant effects [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Steroidal Saponins from Water Eggplant (Fruits of Solanum torvum) Exhibit Anti-Epileptic Activity against Pentylenetetrazole-Induced Seizure Model in Zebrafish

Ren,

Zhang,

Shu

et al. 2024

Molecules

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The fruits of Solanum torvum Swartz, a wild relative of eggplant, are consumed as a wild vegetable in tropical regions of Africa, Asia, and South America. In traditional Chinese medicine, it is believed to have anti-inflammatory and sedative effects. In the Philippines, water decoction is used to treat hyperactivity disorder. Twenty-two steroidal saponins were isolated and purified from the fruits grown in Yunnan, China, including six new compounds: torvosides U–Z (1–6). During drying and cooking, the saponins may undergo transformation, resulting in small amounts of sapogenins. These transformations can include dehydration of hydroxyl groups at position C22, formation of double bonds at position 20, 22 or 22, 23, and even formation of peroxide products. Saponin compounds torvoside X (4), torvoside Y (5), torvoside A (7), and (25S)-3-oxo-5α-spirostan-6α-yl-O-β-D-xylopyranoside (20), which are glycosylated at C-6, showed certain anti-epileptic activity in a pentylenetetrazole-induced zebrafish seizure model. No antiproliferative activity was detected when tested on the cancer cell line HepG2, and no hepatotoxic effect was noted on normal liver cell line LO2.

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“…Traditional Chinese Medicine (TCM), including herbal medicine and acupuncture, has played a pivotal role in health management [ 11 , 12 ]. Some studies have shown therapeutic synergies when acupuncture and herbal medicine are combined across various disease models compared with either therapy alone.…”

Section: Introductionmentioning

confidence: 99%

“…Herbal medicine remedies have been effective in treating adult epilepsy, particularly in decreasing seizure frequency and normalizing electroencephalogram (EEG) patterns [ 12 , 18 , 19 ]. Acupuncture, on the other hand, has also traditionally been used in adult epilepsy care [ 20 ], and recent studies suggest that it could be beneficial for adult patients with epilepsy when combined with Western medicine [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials

Su,

Chen,

Kao

et al. 2024

PLoS ONE

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Objective To evaluate the efficacy and safety of herbal medicine and acupuncture combination for pediatric epilepsy treatment. Methods Databases were searched from their interception until October 2023 to identify randomized controlled trials focusing on the therapeutic efficacy of herbal medicine-acupuncture combination (intervention group) for pediatric epilepsy. The primary outcome was the risk of treatment failure, whereas the secondary outcomes included the risk of post-treatment electroencephalogram (EEG) abnormalities and adverse events. Subgroup analyses were conducted based on the type of herbal compound formulas. Meta-regression analysis was conducted to examine the influence of patient demographics and clinical history on the therapeutic efficacy of herbal medicine-acupuncture combination for pediatric epilepsy. To assess the cumulative evidence, trial sequential analysis (TSA) was performed. Results The analysis included 10 trials involving a total of 882 pediatric patients. Meta-analysis revealed that the intervention group had a lower risk of treatment failure than the control group (risk ratio [RR] = 0.3, 95% confidence interval [CI]: 0.19–0.47, P<0.00001, I2 = 0%, 10 trials). Subgroup analyses showed that therapeutic efficacy was consistent among the different herbal compound formulas. Meta-regression analysis revealed that the efficacy of the treatments did not significantly vary with patient age, male sex, and duration of seizure history. TSA suggested that herbal medicine-acupuncture combination exerted a robust and conclusive effect on seizure treatment. Although the combined used of herbal medicine and acupuncture was not associated with a lower risk of post-treatment EEG abnormalities (RR = 0.82, 95%CI:0.6–1.11, P = 0.2, 3 trials), the risk of adverse events was reduced (RR = 0.27, 95%CI:0.18–0.41, P<0.00001, 4 trials). Conclusion The meta-analysis suggested that combined use of herbal medicine and acupuncture is a promising and safe clinical approach for pediatric epilepsy treatment. Further large-scale studies are necessary to conclusively determine the efficacy and safety of herbal medicine and acupuncture in pediatric epilepsy treatment.

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Research progress on the treatment of epilepsy with traditional Chinese medicine

Cited by 15 publications

References 69 publications

Taiwan Chingguan Yihau (NRICM101) prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system

Taiwan Chingguan Yihau (NRICM101) prevents kainic acid-induced seizures in rats by modulating neuroinflammation and the glutamatergic system

Steroidal Saponins from Water Eggplant (Fruits of Solanum torvum) Exhibit Anti-Epileptic Activity against Pentylenetetrazole-Induced Seizure Model in Zebrafish

Efficacy and safety of herbal medicine combined with acupuncture in pediatric epilepsy treatment: A meta-analysis of randomized controlled trials

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