Research progress on the structural characterization, biological activity and product application of polysaccharides from Crataegus pinnatifida

Jing, Yongshuai; Yan, Meng; Liu, Dongbo; Cheng, Tao; Hu, Beibei; Sun, Shiguo; Zheng, Yuguang; Wu, Liqing

doi:10.1016/j.ijbiomac.2023.125408

Cited by 11 publications

(5 citation statements)

References 57 publications

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Section: Biological Activity Of Polysaccharidesmentioning

confidence: 99%

“…For example, Dendrobium polysaccharides, Astragalus polysaccharides, Lycium barbarum polysaccharides, and panax notoginseng polysaccharides have shown this effect [44][45][46][47]. Polysaccharides from food sources, such as coriander polysaccharides, pomegranate polysaccharides, chestnut polysaccharides, and papaya polysaccharides, also demonstrate antitumor effects [48][49][50][51]. The relative molecular mass distribution of polysaccharides, the composition of sugar groups, the type of glycosidic bonding and the way adjacent glycosidic bonds are connected, the presence or absence of branched chains as well as their position and length, and the non-sugar modifications may have a significant effect on their activity, as shown in Figure 2.…”

Section: Biological Activity Of Polysaccharidesmentioning

confidence: 99%

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Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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Clinical drug administration aims to deliver drugs efficiently and safely to target tissues, organs, and cells, with the objective of enabling their therapeutic effects. Currently, the main approach to enhance a drug’s effectiveness is ensuring its efficient delivery to the intended site. Due to the fact that there are still various drawbacks of traditional drug delivery methods, such as high toxicity and side effects, insufficient drug specificity, poor targeting, and poor pharmacokinetic performance, nanocarriers have emerged as a promising alternative. Nanocarriers possess significant advantages in drug delivery due to their size tunability and surface modifiability. Moreover, nano-drug delivery systems have demonstrated strong potential in terms of prolonging drug circulation time, improving bioavailability, increasing drug retention at the tumor site, decreasing drug resistance, as well as reducing the undesirable side effects of anticancer drugs. Numerous studies have focused on utilizing polysaccharides as nanodelivery carriers, developing delivery systems based on polysaccharides, or exploiting polysaccharides as tumor-targeting ligands to enhance the precision of nanoparticle delivery. These types of investigations have become commonplace in the academic literature. This review aims to elucidate the preparation methods and principles of polysaccharide gold nanocarriers. It also provides an overview of the factors that affect the loading of polysaccharide gold nanocarriers with different kinds of drugs. Additionally, it outlines the strategies employed by polysaccharide gold nanocarriers to improve the delivery efficiency of various drugs. The objective is to provide a reference for further development of research on polysaccharide gold nanodelivery systems.

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Section: Biological Activity Of Polysaccharidesmentioning

confidence: 99%

Section: Biological Activity Of Polysaccharidesmentioning

confidence: 99%

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Song,

Aipire,

Dilxat

et al. 2024

Pharmaceutics

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“…Crataegus pinnatifida (CP), known as Shan Zha or hawthorn, is a popular functional food in China. It has a tart-sweet taste and is abundant in phenols, flavonoids, terpenoids, fiber, and organic acids [ 12 , 13 , 14 ]. It has been documented that these chemical constituents exhibit a wide range of pharmacological effects, including anticancer properties, antioxidant activity, improvement of glycolipid metabolism, and facilitation of digestive processes [ 12 , 13 , 14 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has a tart-sweet taste and is abundant in phenols, flavonoids, terpenoids, fiber, and organic acids [ 12 , 13 , 14 ]. It has been documented that these chemical constituents exhibit a wide range of pharmacological effects, including anticancer properties, antioxidant activity, improvement of glycolipid metabolism, and facilitation of digestive processes [ 12 , 13 , 14 , 15 , 16 ]. Wolfiporia extensa (WE), or Fu Ling, is an edible fungus with a long consumption history.…”

Section: Introductionmentioning

confidence: 99%

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Yuan,

Hu,

Yang

et al. 2024

Foods

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Obesity is a multifactorial chronic metabolic disease with multiple complications. Crataegus pinnatifida (CP) and Wolfiporia extensa (WE) are traditional functional foods with improving metabolic health properties. This study demonstrated the effect of CP and WE combination on ameliorating obesity induced by a high-fat diet (HFD). Moreover, the CP-WE food pair ameliorated HFD-induced metabolic disorders, including glucose intolerance, insulin resistance, hyperlipidemia, and hepatic steatosis. 16S rRNA gene amplicon sequencing and analysis revealed that CP combined with WE reshaped the composition of gut microbiota in HFD-fed mice. Furthermore, correlation analysis revealed a substantial association between the obesity-related parameters and the shifts in predominant bacterial genera influenced by the food pair intervention. In conclusion, this study demonstrated that the CP-WE food pair ameliorated HFD-induced obesity and reshaped gut microbiota composition, providing a promising approach to combat obesity through specific food combinations.

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“…Under the above conditions, the extraction yield of crude P. frutescens leaf polysaccharide reached up to 5.22 ± 0.17%. HWE has advantages of being a relatively simple, low-cost, and non-polluting process (24); however, this method suffers from the drawbacks of a long operating time, low yield, and the need for repetitive operations (25). Thus, HWE should be combined with other innovative technologies such as ultrasonic-assisted extraction (UAE), microwave-assisted extraction (MAE), and ultrasonic-assisted enzyme extraction (UAEE).…”

mentioning

confidence: 99%

Recent trends in extraction, purification, structural characterization, and biological activities evaluation of Perilla frutescens (L.) Britton polysaccharide

Zhu,

Guan,

Wang

et al. 2024

Front. Nutr.

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Perilla frutescens (L.) Britton is an annual herb plant of the Perilla genus in the Labiatae family, which is commonly utilized as an edible and medicinal resource. Polysaccharides are among the major components and essential bioactive compounds of P. frutescens, which exhibit a multitude of biological activities, including antioxidant, antitumor, anti-fatigue, immunoregulation, hepatoprotective, anti-inflammatory, and lipid-lowering effects. As a natural carbohydrate, P. frutescens polysaccharide has the potential to be utilized in the development of drugs and functional materials. In this paper, we provide an overview of progress made on the extraction, purification, structural characterization, and bioactivity of polysaccharides from different parts of P. frutescens. The challenges and opportunities for research are discussed, along with the potential development prospects and future areas of focus in the study of P. frutescens polysaccharides.

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Research progress on the structural characterization, biological activity and product application of polysaccharides from Crataegus pinnatifida

Cited by 11 publications

References 57 publications

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

Research Progress of Polysaccharide-Gold Nanocomplexes in Drug Delivery

The Effects of Crataegus pinnatifida and Wolfiporia extensa Combination on Diet-Induced Obesity and Gut Microbiota

Recent trends in extraction, purification, structural characterization, and biological activities evaluation of Perilla frutescens (L.) Britton polysaccharide

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