Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use

Feng, Mengyu; Zheng, Xin; Wan, Juan; Pan, Wenjing; Xie, Xinya; Hu, Baozhu; Wang, Yingzi; Huang, Wen; Cai, Shumin

doi:10.1039/d0fo02921a

Cited by 16 publications

(16 citation statements)

References 188 publications

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“…17 It inhibits the bitterness and astringency of other foods; improves their flavor; 18 and has notable bioactivities including anti-inflammation, antistress, relaxation, antiapoptosis, hypolipidemia, immunoregulation, and antioxidation. 19–22 Therefore, as a natural biologically active compound, l -theanine is a favorable choice to cope with heat stress.…”

Section: Introductionmentioning

confidence: 99%

l-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice

Liu

et al. 2022

Food Funct.

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Section: Introductionmentioning

confidence: 99%

l-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice

Liu

et al. 2022

Food Funct.

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“…11,12 Hence, the advancement of sunscreen products to protect against UVB irradiation has drawn widespread attention. 31,32 Here, we found for the first time that ginsenoside Rk1, a rare ginsenoside, is the key active component extracted from ginseng. It substantially diminished skin photoaging in UVB-irradiated BALB/c nude mouse skin and HaCaT keratinocytes by reversing oxidative stress, the inflammatory response, and collagen degradation mediated by the PI3K/AKT/NF-κB signaling pathway.…”

Section: ■ Discussionmentioning

confidence: 79%

“…Acute and long-term exposure of the skin to UVB has been demonstrated to cause irreversible damage to cellular components, have a significant effect on the development of skin aging, and sometimes even bring about skin cancer. , Hence, the advancement of sunscreen products to protect against UVB irradiation has drawn widespread attention. , Here, we found for the first time that ginsenoside Rk1, a rare ginsenoside, is the key active component extracted from ginseng. It substantially diminished skin photoaging in UVB-irradiated BALB/c nude mouse skin and HaCaT keratinocytes by reversing oxidative stress, the inflammatory response, and collagen degradation mediated by the PI3K/AKT/NF-κB signaling pathway.…”

Section: Discussionmentioning

confidence: 80%

Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradation via the PI3K/AKT/NF-κB Pathway In Vitro and In Vivo

Liu

Wan

et al. 2022

J. Agric. Food Chem.

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Long-term exposure to ultraviolet (UV) irradiation, especially UVB, can trigger destructive intracellular effects, including various types of DNA damage, oxidative stress, and inflammatory responses, leading to accelerated skin aging. Ginsenoside Rk1, a rare ginsenoside pertaining to panaxadiol saponins, has been certified to possess underlying anti-inflammatory effects. Nevertheless, the efficiency of Rk1 against the photoaging of human skin and the latent molecular mechanisms are still unclear. Here, UVB-irradiated HaCaT keratinocytes were used as an in vitro model, and UVB-irradiated BALB/c nude mouse dorsal skin was established as an in vivo model to explore the mechanism by which Rk1 protects skin. Consequently, we found that Rk1 administration significantly attenuated oxidative stress by suppressing reactive oxygen species (ROS) overproduction and strengthening the activities of antioxidant enzymes. The UVB-induced inflammatory response was alleviated by Rk1 application via regulation of the secretion of various proinflammatory cytokines. Additionally, western blot assays illustrated that Rk1 intervention inhibited collagen degradation by reducing the expression of matrix metalloproteinases. Further studies revealed that Rk1 could suppress the PI3K/AKT/NF-κB signaling pathways in vitro and in vivo. Molecular docking results indicated that Rk1 might effectively bind to the active pockets of PI3K, AKT, and NF-κB. The PI3K activator 740 Y-P clearly reversed the effects of Rk1 on oxidative stress, the inflammatory response, and collagen degradation in UVB-irradiated HaCaT cells. Moreover, histological and Masson staining verified that the administration of Rk1 to BALB/c nude mice remarkably ameliorated UVB-induced skin roughness, epidermal thickening, collagen fiber arrangement disorder, and wrinkles. Overall, the evidence provided in this study suggested that Rk1 could be applied for the development of effective natural antiphotoaging agents for skin health.

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“…Tea is one of the three most consumed beverages in the world and is known as the beverage of the twenty-first century, not only because of the long history of tea culture but also because of its nutritional value and health care functions ( 34 , 35 ). Studies have shown that tea contains numerous active ingredients, mainly tea polyphenols, tea pigments, tea polysaccharides, γ-aminobutyric acid, tea saponins, alkaloids, vitamins, pyrroloquinoline quinone, pantothenic acid, minerals, and other ingredients ( 36 , 37 ). Tea polyphenols are the most abundant soluble components in tea, and they are also the most important substances in tea that exert biological effects ( 35 ) that can reduce the incidence of cardiovascular disease, decrease blood lipids, decrease body fat formation, and change the intestinal flora ecology ( 35 , 38 ).…”

Section: Discussionmentioning

confidence: 99%

Tea Ingredients Have Anti-coronavirus Disease 2019 (COVID-19) Targets Based on Bioinformatics Analyses and Pharmacological Effects on LPS-Stimulated Macrophages

et al. 2022

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Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that caused millions of deaths and lacks treatment. Although several studies have focused on the major component of green tea, epigallocatechin 3-gallate (EGCG), which is efficient in preventing COVID-19, systemic analyses of the anti-COVID-19 potential of green tea remain insufficient. Here, we co-analyzed the target genes of tea ingredients and COVID-19 signature genes and found that epigallocatechin 3-acetalbehyde was capable of reversing the major molecular processes of COVID-19 (MAPK and NF-κB activation). These findings were further supported by Western blotting (WB), immunofluorescence, and quantitative polymerase chain reaction (qPCR) in LPS-stimulated macrophages. Moreover, using molecular docking analysis, we identified three tea ingredients ((-)-catechin gallate, D-(+)-cellobiose, and EGCG) that may interact with the vital SARS-CoV-2 protein, 5R84, compared with the qualified 5R84 ligand WGS. Thus, our results indicated that tea ingredients have the potential to treat COVID-19 by suppressing the COVID-19 signature genes and interacting with the vital SARS-CoV-2 protein.

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Research progress on the potential delaying skin aging effect and mechanism of tea for oral and external use

Abstract: Tea for oral and external use can anti-UV, antioxidant, anti-inflammatory, inhibit the aging of extracellular matrix, balance intestinal and skin microorganisms, improve mood and sleep, and fundamentally make the skin healthy and natural aging.

Cited by 16 publications

References 188 publications

l-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice

l-Theanine mediates the p38MAPK signaling pathway to alleviate heat-induced oxidative stress and inflammation in mice

Ginsenoside Rk1 Prevents UVB Irradiation-Mediated Oxidative Stress, Inflammatory Response, and Collagen Degradation via the PI3K/AKT/NF-κB Pathway In Vitro and In Vivo

Tea Ingredients Have Anti-coronavirus Disease 2019 (COVID-19) Targets Based on Bioinformatics Analyses and Pharmacological Effects on LPS-Stimulated Macrophages

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