Research progress on the mechanism of cerebral blood flow regulation in hypoxia environment at plateau

Guisheng, Hao; Fan, Qingli; Hu, Quanzhong; Hou, Qi

doi:10.1080/21655979.2021.2024950

Cited by 5 publications

(1 citation statement)

References 32 publications

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“…The main reason is that its mechanism is complicated, involving a series of pathological changes such as cerebral blood flow disturbance, disruption of the blood-brain barrier (BBB), and brain parenchymal cell damage induced by inflammatory factors in a low-pressure hypoxic environment. 9 , 10 Recently, studies have found that REDOX homeostasis plays an important role in the occurrence, development and outcome of HACE. 2 , 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Li¹,

Li²,

Luo³

et al. 2023

JIR

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With the increasing of altitude activities from low-altitude people, the study of high altitude cerebral edema (HACE) has been revived. HACE is a severe acute mountain sickness associated with exposure to hypobaric hypoxia at high altitude, often characterized by disturbance of consciousness and ataxia. As for the pathogenesis of HACE, previous studies suggested that it might be related to the disorder of cerebral blood flow, the destruction of blood-brain barrier and the injury of brain parenchyma cells caused by inflammatory factors. In recent years, studies have confirmed that the imbalance of REDOX homeostasis is also involved in the pathogenesis of HACE, which mainly leads to abnormal activation of microglia and destruction of tight junction of vascular endothelial cells through the excessive production of mitochondrial-related reactive oxygen species. Therefore, this review summarizes the role of REDOX homeostasis and the potential of the treatment of REDOX homeostasis in HACE, which is of great significance to expand the understanding of the pathogenesis of HACE. Moreover, it will also be helpful to further study the possible therapy of HACE related to the key link of REDOX homeostasis.

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Section: Introductionmentioning

confidence: 99%

Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Li¹,

Li²,

Luo³

et al. 2023

JIR

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Assessment of Dynamic Cerebral Autoregulation During Long‐Term Exposure to High Altitude in Normal Subjects by Ultrasonography

Liang,

Gao,

Chen

et al. 2024

J of Ultrasound Medicine

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PurposeTo evaluate changes in dynamic cerebral autoregulation (CA) during short‐term and long‐term exposure to high altitude with ultrasonography, and also study the sex differences in the response of CA to altitude.MethodsWe assessed the differences in dynamic CA and measured with Doppler ultrasound of the bilateral internal carotid artery (ICA), vertebral artery (VA), and middle cerebral artery (MCA) and the values of basic information within 48 hours and at 2 years after arrival at Tibet in 65 healthy Han young Chinese volunteers, meanwhile, we compared the resistance index (RI) and pulsatility index (PI) of the right MCA at inhale oxygen 8 minutes when a newcomer with 2 years after arrival at Tibet.ResultsWith 2 years of altitude exposure, the SaO2 of all subjects was above 90%, the mean PEF, DAP, and HR values decreased, HGB increased compared within 48 hours in same‐gender groups. Comparisons of cerebral hemodynamics between before 2 years and after 2 years within male and female groups, the mean RI and PI values of bilateral MCA after 2 years were significantly higher than before 2 years, at the same time, the mean RI and PI values of bilateral ICA were significant differences (P < .05) between male groups, with regard to female groups, showed that the mean RI and PI values of bilateral VA were significant differences (P < .05). Comparisons of Right MCA hemodynamics between after oxygen uptake 8 minutes and 2 years, the mean RI and PI values were no significant difference within male and female groups (P > .05).ConclusionsAcute mountain sickness could result from an alteration of dynamic autoregulation of cerebral blood flow, but the impaired autoregulation may be corrected with the extension of time, furthermore, the response of CA to altitude in males and females are different.

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A conjoint analysis of renal structure and omics characteristics reveal new insight to yak high-altitude hypoxia adaptation

Ding,

Zhao,

et al. 2024

Genomics

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Research progress on the mechanism of cerebral blood flow regulation in hypoxia environment at plateau

Cited by 5 publications

References 32 publications

Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Progress in the Treatment of High Altitude Cerebral Edema: Targeting REDOX Homeostasis

Assessment of Dynamic Cerebral Autoregulation During Long‐Term Exposure to High Altitude in Normal Subjects by Ultrasonography

A conjoint analysis of renal structure and omics characteristics reveal new insight to yak high-altitude hypoxia adaptation

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