Research progress on Sirtuins (SIRTs) family modulators

Chen, Mingkai; Tan, Junfei; Jin, Zihan; Jiang, Tingting; Wu, Jiabiao; Yu, Xiaolong

doi:10.1016/j.biopha.2024.116481

Cited by 7 publications

(2 citation statements)

References 318 publications

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“…There is also continuing search for identification of STACs, such as resveratrol, that could be used to alleviate or postpone age-related diseases and promote healthy aging. There has been much discussion on the effects of SIRT1 and other sirtuins and many labs have contributed to improve our understanding of its biological role and its enzymatic activity ( Bonkowski and Sinclair, 2016 ; Dai et al, 2018 ; M; Chen et al, 2024 ). This remarkable body of work provides a framework and promise for future studies on the role of SIRT1, and its activators in health, disease and aging.…”

Section: Discussionmentioning

confidence: 99%

SIRT1, resveratrol and aging

Rogina,

Tissenbaum

2024

Front. Genet.

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Aging is linked to a time-associated decline in both cellular function and repair capacity leading to malfunction on an organismal level, increased frailty, higher incidence of diseases, and death. As the population grows older, there is a need to reveal mechanisms associated with aging that could spearhead treatments to postpone the onset of age-associated decline, extend both healthspan and lifespan. One possibility is targeting the sirtuin SIRT1, the founding member of the sirtuin family, a highly conserved family of histone deacetylases that have been linked to metabolism, stress response, protein synthesis, genomic instability, neurodegeneration, DNA damage repair, and inflammation. Importantly, sirtuins have also been implicated to promote health and lifespan extension, while their dysregulation has been linked to cancer, neurological processes, and heart disorders. SIRT1 is one of seven members of sirtuin family; each requiring nicotinamide adenine dinucleotide (NAD+) as co-substrate for their catalytic activity. Overexpression of yeast, worm, fly, and mice SIRT1 homologs extend lifespan in each animal, respectively. Moreover, lifespan extension due to calorie restriction are associated with increased sirtuin activity. These findings led to the search for a calorie restriction mimetic, which revealed the compound resveratrol; (3, 5, 4′-trihydroxy-trans-stilbene) belonging to the stilbenoids group of polyphenols. Following this finding, resveratrol and other sirtuin-activating compounds have been extensively studied for their ability to affect health and lifespan in a variety of species, including humans via clinical studies.

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Section: Discussionmentioning

confidence: 99%

SIRT1, resveratrol and aging

Rogina,

Tissenbaum

2024

Front. Genet.

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“…Aging is a multifaceted progressive process, depending on endogenous and exogenous factors [9,10]. In recent years, strategies to ease and counteract senescence or even rejuvenate cells and tissues have been proposed [11,12]. Arcuri S. et al [13] investigated the effect of extracellular vesicles (EVs) released by young cells on the cellular hallmarks of aging in senescent cells.…”

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confidence: 99%