Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment

Meng, Fanman; Jin, Guangwei

doi:10.3389/fneur.2022.865920

Cited by 9 publications

(4 citation statements)

References 74 publications

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“…On the clinical level, we found that a higher burden of WMLs was associated with lower cognitive performance, even after controlling for health-related factors. These findings are consistent with previous research [21], highlighting that cognitive changes can be observed at a prodromal stage of disease. Stronger effects were generally found for the immediate recall of words.…”

Section: Discussionsupporting

confidence: 93%

Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

Van der Auwera,

Ameling,

Wittfeld

et al. 2024

IJMS

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White matter lesions (WML) emerge as a consequence of vascular injuries in the brain. While they are commonly observed in aging, associations have been established with neurodegenerative and neurological disorders such as dementia or stroke. Despite substantial research efforts, biological mechanisms are incomplete and biomarkers indicating WMLs are lacking. Utilizing data from the population-based Study of Health in Pomerania (SHIP), our objective was to identify plasma-circulating micro-RNAs (miRNAs) associated with WMLs, thus providing a foundation for a comprehensive biological model and further research. In linear regression models, direct association and moderating factors were analyzed. In 648 individuals, we identified hsa-miR-425-5p as directly associated with WMLs. In subsequent analyses, hsa-miR-425-5p was found to regulate various genes associated with WMLs with particular emphasis on the SH3PXD2A gene. Furthermore, miR-425-5p was found to be involved in immunological processes. In addition, noteworthy miRNAs associated with WMLs were identified, primarily moderated by the factors of sex or smoking status. All identified miRNAs exhibited a strong over-representation in neurodegenerative and neurological diseases. We introduced hsa-miR-425-5p as a promising candidate in WML research probably involved in immunological processes. Mir-425-5p holds the potential as a biomarker of WMLs, shedding light on potential mechanisms and pathways in vascular dementia.

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Section: Discussionsupporting

confidence: 93%

Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

Van der Auwera,

Ameling,

Wittfeld

et al. 2024

IJMS

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“…These changes can include a reduction in white matter volume, disrupted white matter tracts, and an increase in white matter lesions. Such alterations can contribute to cognitive decline and dementia [ 64 , 65 ], indicating that cardiovascular disease have the potential to affect the integrity of the brain’s white matter and, consequently, its cognitive function.…”

Section: Discussionmentioning

confidence: 99%

Association between cardiovascular risk factors and cognitive impairment in adults aged 60 years or older from Chile: a cross-sectional study

Souza-Lima,

Matsudo,

Valdivia-Moral

et al. 2023

BMC Geriatr

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Background Few studies in Latin America have examined the association between cardiovascular risk factors and cognitive impairment (CI) in a nationally representative sample. Therefore, this study aimed to estimate the prevalence of CI in a nationally representative sample of adults aged 60 years or older from Chile and to investigate the association between cardiovascular risk factors and CI. Methods Data from the cross-sectional 2016–2017 National Health Survey of Chile, which included 2031 adults (63.7% women) was used. Body mass index, metabolic syndrome (blood pressure, triglycerides, fasting glucose or treatment for diabetics, waist circumference, and HDL cholesterol), risk of cardiovascular disease (history and measured variables, using the Framingham risk score), tobacco use, and physical activity were measured. CI was assessed using the Mini-Mental Status Examination (MMSE). Results Overall, the prevalence of CI was 12.2% at the national level. Significant differences in CI were observed by age, education level, risk of cardiovascular disease, and smoking. High risk of cardiovascular disease was associated with higher odds of CI (OR: 2.04; 95%CI: 1.20–3.45) compared to low risk. Smoking was significantly associated with a lower likelihood of CI (OR: 0.56; 95%CI: 0.36–0.87) compared to never smoking. Body mass index, metabolic syndrome, and physical activity were not associated with CI. Conclusions This study provided additional support for previous findings on the relationship between cognitive decline and an elevated risk of cardiovascular disease. Worse CI was associated with the group with the highest risk of cardiovascular disease, and the presence of lifestyle factors, such as obesity and physical inactivity, exacerbate this relationship, but not being a current smoker.

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“…However, most studies have only examined functional or anatomical changes in isolation. In recent years, with the rapid development of multimodal MRI technology, researchers have carried out a large number of neuroimaging studies on the structural and functional damage to the brain caused by CSVD (Liu et al, 2019 ; Meng et al, 2022 ). Studies have shown that changes in brain function are often accompanied by changes in the structure of the corresponding brain regions.…”

Section: Introductionmentioning

confidence: 99%

Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease

et al. 2023

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Cerebral small vessel disease (CSVD) is a common chronic and progressive disease that can lead to mental and cognitive impairment. Damage to brain structure and function may play an important role in the neuropsychiatric disorders of patients with CSVD. Increasing evidence suggests that functional changes are accompanied by structural changes in corresponding brain regions. Thus, normal structure–function coupling is essential for optimal brain performance, and disrupted structure–function coupling can be found in many neurological and psychiatric disorders. To date, most studies on patients with CSVD have focused on separate structures or functions, including reductions in white matter volume and blood flow, which lead to cognitive dysfunction. However, there are few studies on brain structure–function coupling in patients with CSVD. In recent years, with the rapid development of multilevel (voxel-wise, neurovascular, regional level, and network level) brain structure–functional coupling analysis methods based on multimodal magnetic resonance imaging (MRI), new evidence has been provided to reveal the correlation between brain function and structural abnormalities and cognitive impairment. Therefore, studying brain structure–function coupling has a potential significance in the exploration and elucidation of the neurobiological mechanism of cognitive impairment in patients with CSVD. This article mainly describes the currently popular brain structure–function coupling analysis technology based on multimodal MRI and the important research progress of these coupling technologies on CSVD and cognitive impairment to provide a perspective for the study of the pathogenesis and early diagnosis of CSVD.

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Research Progress on MRI for White Matter Hyperintensity of Presumed Vascular Origin and Cognitive Impairment

Cited by 9 publications

References 74 publications

Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

Circulating microRNA miR-425-5p Associated with Brain White Matter Lesions and Inflammatory Processes

Association between cardiovascular risk factors and cognitive impairment in adults aged 60 years or older from Chile: a cross-sectional study

Brain structure–function coupling associated with cognitive impairment in cerebral small vessel disease

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