Research progress on mechanical properties and wear resistance of cartilage repair hydrogel

Wu, Yuyao; Li, Xuelin; Wang, Yifei; Shi, Yanchao; Wang, Fei; Lin, Guimei

doi:10.1016/j.matdes.2022.110575

Cited by 14 publications

(8 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The hydrogel showed compressive moduli of 0.33 MPa and 0.12 MPa, respectively, when compressed parallel and perpendicular to the macroporous channels. These moduli are in the same range as native articular cartilage [47][48][49][50][51][52][53][54][55]. Consecutive cyclic (showed hysteresis loop) and stress relaxation (overall stress relaxed around 30%) tests revealed that the Gel-PEG hydrogel was viscoelastic in nature, which made the hydrogel a potential platform for cartilage tissue engineering [38].…”

Section: Stress Relaxation Behavior Of the Anisotropic Gel-peg Hybrid...mentioning

confidence: 79%

Designing Viscoelastic Gelatin-PEG Macroporous Hybrid Hydrogel with Anisotropic Morphology and Mechanical Properties for Tissue Engineering Application

Dey

Agnelli

Sartore

2023

Micro

View full text Add to dashboard Cite

The mechanical properties of scaffolds play a vital role in regulating key cellular processes in tissue development and regeneration in the field of tissue engineering. Recently, scaffolding material design strategies leverage viscoelasticity to guide stem cells toward specific tissue regeneration. Herein, we designed and developed a viscoelastic Gel-PEG hybrid hydrogel with anisotropic morphology and mechanical properties using a gelatin and functionalized PEG (as a crosslinker) under a benign condition for tissue engineering application. The chemical crosslinking/grafting reaction was mainly involved between epoxide groups of PEG and available functional groups of gelatin. FTIR spectra revealed the hybrid nature of Gel-PEG hydrogel. The hybrid hydrogel showed good swelling behavior (water content > 600%), high porosity and pore interconnectivity suitable for tissue engineering application. Simple unidirectional freezing followed by a freeze-drying technique allowed the creation of structurally stable 3D anisotropic macroporous architecture that showed tissue-like elasticity and was capable of withstanding high deformation (50% strain) without being damaged. The tensile and compressive modulus of Gel-PEG hybrid hydrogel were found to be 0.863 MPa and 0.330 MPa, respectively, which are within the range of normal human articular cartilage. In-depth mechanical characterizations showed that the Gel-PEG hybrid hydrogel possessed natural-tissue-like mechanics such as non-linear and J-shaped stress-strain curves, stress softening effect, high fatigue resistance and stress relaxation response. A month-long hydrolytic degradation test revealed that the hydrogel gradually degraded in a homogeneous manner over time but maintained its structural stability and anisotropic mechanics. Overall, all these interesting features provide a potential opportunity for Gel-PEG hybrid hydrogel as a scaffold in a wide range of tissue engineering applications.

show abstract

Section: Stress Relaxation Behavior Of the Anisotropic Gel-peg Hybrid...mentioning

confidence: 79%

Designing Viscoelastic Gelatin-PEG Macroporous Hybrid Hydrogel with Anisotropic Morphology and Mechanical Properties for Tissue Engineering Application

Dey

Agnelli

Sartore

2023

Micro

View full text Add to dashboard Cite

show abstract

“…Regardless of the factors resulting from the wounds themselves, hydrogels must also meet other conditions, such as good mechanical properties, which include both resistance to compression and resistance to stretching [74,75]. These properties allow the hydrogels to withstand heavy loads and strains during their application in critical places of the body, such as the joints or neck.…”

Section: Challenges Related To Hydrogel-based Wound Dressingsmentioning

confidence: 99%

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

Michalicha,

Belcarz,

Giannakoudakis

et al. 2024

Materials

View full text Add to dashboard Cite

Effective wound treatment has become one of the most important challenges for healthcare as it continues to be one of the leading causes of death worldwide. Therefore, wound care technologies significantly evolved in order to provide a holistic approach based on various designs of functional wound dressings. Among them, hydrogels have been widely used for wound treatment due to their biocompatibility and similarity to the extracellular matrix. The hydrogel formula offers the control of an optimal wound moisture level due to its ability to absorb excess fluid from the wound or release moisture as needed. Additionally, hydrogels can be successfully integrated with a plethora of biologically active components (e.g., nanoparticles, pharmaceuticals, natural extracts, peptides), thus enhancing the performance of resulting composite hydrogels in wound healing applications. In this review, the-state-of-the-art discoveries related to stimuli-responsive hydrogel-based dressings have been summarized, taking into account their antimicrobial, anti-inflammatory, antioxidant, and hemostatic properties, as well as other effects (e.g., re-epithelialization, vascularization, and restoration of the tissue) resulting from their use.

show abstract

“…One disadvantage of this approach is the mismatch of mechanical properties between the injected biomaterial (which is often a type of hydrogel, e.g. collagen or polyethylene glycol-based) and the native cartilage, which has a complex gradation of varying compressive and tensile properties between the deep zone and superficial layers [12][13][14]. Whilst the stiffness of injected hydrogels can be improved by the inclusion of composites materials (e.g.…”

Section: Introductionmentioning

confidence: 99%

A 4D printed self-assembling PEGDA microscaffold fabricated by digital light processing for arthroscopic articular cartilage tissue engineering

Hao

et al. 2022

Prog Addit Manuf

View full text Add to dashboard Cite

Articular cartilage in synovial joints such as the knee has limited capability to regenerate independently, and most clinical options for focal cartilage repair merely delay total joint replacement. Tissue engineering presents a repair strategy in which an injectable cell-laden scaffold material is used to reconstruct the joint in situ through mechanical stabilisation and cell-mediated regeneration. In this study, we designed and 3D-printed millimetre-scale micro-patterned PEGDA biomaterial microscaffolds which self-assemble through tessellation at a scale relevant for applications in osteochondral cartilage reconstruction. Using simulated chondral lesions in an in vitro model, a series of scaffold designs and viscous delivery solutions were assessed. Hexagonal microscaffolds (750 μm x 300 μm) demonstrated the best coverage of a model cartilage lesion (at 73.3%) when injected with a 1% methyl cellulose solution. When chondrocytes were introduced to the biomaterial via a collagen hydrogel, they successfully engrafted with the printed microscaffolds and survived for at least 14 days in vitro, showing the feasibility of reconstructing stratified cartilaginous tissue using this strategy. Our study demonstrates a promising application of this 4D-printed injectable technique for future clinical applications in osteochondral tissue engineering.

show abstract

Research progress on mechanical properties and wear resistance of cartilage repair hydrogel

Cited by 14 publications

References 58 publications

Designing Viscoelastic Gelatin-PEG Macroporous Hybrid Hydrogel with Anisotropic Morphology and Mechanical Properties for Tissue Engineering Application

Designing Viscoelastic Gelatin-PEG Macroporous Hybrid Hydrogel with Anisotropic Morphology and Mechanical Properties for Tissue Engineering Application

Designing Composite Stimuli-Responsive Hydrogels for Wound Healing Applications: The State-of-the-Art and Recent Discoveries

A 4D printed self-assembling PEGDA microscaffold fabricated by digital light processing for arthroscopic articular cartilage tissue engineering

Contact Info

Product

Resources

About