Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification

Chen, Wenting; Liu, Jinxi; Zhang, Caiyun; Bai, Que; Gao, Qian; Zhang, Yanni; Dong, Kai; Lu, Tingli

doi:10.2147/ijn.s366187

Cited by 16 publications

(8 citation statements)

References 168 publications

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“…Under NIR irradiation, GA-Fe@EMB could effectively increase the temperature of the tumor area and exerted a photothermal effect. Fenton reaction rate is affected by the Fe 3+ /Fe 2+ conversion rate, H 2 O 2 dosage, and Fenton reaction conditions (such as temperature and acidity). − At the same time, GA could reduce Fe 3+ to Fe 2+ , thus providing the continuous catalyst for the Fenton reaction; the photothermal effect of GA-Fe increased the temperature of the Fenton reaction; the released of EMB down-regulates SLC16A1/3 and promoted lactic acid accumulation, which further drives the Fenton reaction and promotes ROS accumulation, thus increasing the lethality of nanoparticles to cervical cancer cells.…”

Section: Discussionmentioning

confidence: 99%

“…It was observed that the inhibitory effect of CDDP on the proliferation of SiHa and HeLa cells was lower than that of EMB on cervical cancer. It was found for the first time that EMB simultaneously inhibited the mRNA and protein expression of SLC16A1/3 to promote the accumulation of lactic acid in cells, further inhibited glycolysis, and drove oxidative stress to exert the anti-cervical cancer effect together …”

Section: Discussionmentioning

confidence: 99%

“…It was found for the first time that EMB simultaneously inhibited the mRNA and protein expression of SLC16A1/3 to promote the accumulation of lactic acid in cells, further inhibited glycolysis, and drove oxidative stress to exert the anti-cervical cancer effect together. 35 In this paper, GA-Fe@EMB nanoparticles with good biocompatibility were synthesized to deliver EMB with poor water solubility, which improved the overall anti-cervical cancer performance. GA-Fe@EMB had some certain cytotoxicity, but the cytotoxicity was lower than EMB, which was due to the incomplete release of EMB.…”

Section: Discussionmentioning

confidence: 99%

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Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer

et al. 2023

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SLC16A1 and SLC16A3 (SLC16A1/3) are highly expressed in cervical cancers and associated with the malignant biological behavior of cancer. SLC16A1/3 is the critical hub for regulating the internal and external environment, glycolysis, and redox homeostasis in cervical cancer cells. Inhibiting SLC16A1/3 provides a new thought to eliminate cervical cancer effectively. There are few reports on effective treatment strategies to eliminate cervical cancer by simultaneously targeting SLC16A1/3. GEO database analysis and quantitative reverse transcription polymerase chain reaction experiment were used to confirm the high expression of SLC16A1/3. The potential inhibitor of SLC16A1/3 was screened from Siwu Decoction by using network pharmacology and molecular docking technology. The mRNA levels and protein levels of SLC16A1/3 in SiHa and HeLa cells treated by Embelin (EMB) were clarified, respectively. Furthermore, the Gallic acid-iron (GA-Fe) drug delivery system was used to improve its anti-cancer performance. Compared with normal cervical cells, SLC16A1/3 mRNA was over-expressed in SiHa and HeLa cells. Through the analysis of Siwu Decoction, a simultaneously targeted SLC16A1/3 inhibitor EMB was discovered. It was found for the first time that EMB promoted lactic acid accumulation and further induced redox dyshomeostasis and glycolysis disorder by simultaneously inhibiting SLC16A1/3. The gallic acid-iron-Embelin (GA-Fe@EMB) drug delivery system delivered EMB, which had a synergistic anti-cervical cancer effect. Under the irradiation of a near-infrared laser, the GA-Fe@EMB could elevate the temperature of the tumor area effectively. Subsequently, EMB was released and mediated the lactic acid accumulation and the GA-Fe nanoparticle synergistic Fenton reaction to promote ROS accumulation, thereby increasing the lethality of the nanoparticles on cervical cancer cells. GA-Fe@EMB can target cervical cancer marker SLC16A1/3 to regulate glycolysis and redox pathways, synergistically with photothermal therapy, which provides a new avenue for the synergistic treatment of malignant cervical cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer

et al. 2023

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“…Continuous hypoxia leads to high expression of the hypoxia-inducing factor (HIF-1α), which makes the tumor evolve into a more metastatic and invasive clinical phenotype. Angiogenesis factors induced by hypoxia environment promote tumor cells to infiltrate more efficiently and metastasize to distant areas. − Both chemodynamic therapy (CDT) and photodynamic therapy (PDT) are selective therapies mediated by reactive oxygen species − which can induce immunogenic cell death (ICD) by damaging cells under endogenous and exogenous stimuli, and the tumor microenvironment changes from immunosuppressive to antitumor, triggering systemic immune activity. PDT and CDT combining with immunotherapy adjuvant can inhibit tumor metastasis. − However, although the combination of ICD and immunotherapy adjuvant has achieved many significant effects, the ICD induced by PDT or CDT alone is generally weak.…”

Section: Introductionmentioning

confidence: 99%

Immunogenic Cell Death Induction and Oxygenation by Multifunctional Hollow Silica/Copper-Doped Carbon Dots

Liu,

Zhang,

Bao

et al. 2024

ACS Appl. Mater. Interfaces

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The metastasis and recurrence of cancer are related to immunosuppression and hypoxia in the tumor microenvironment. Activating immune activity and improving the hypoxic environment face essential challenges. This paper reports on a multifunctional nanomaterial, HSCCMBC, that induces immunogenic cell death through powerful photodynamic therapy/chemodynamic therapy synergistic antitumor effects. The tumor microenvironment changed from the immunosuppressive type to immune type, activated the immune activity of the system, decomposed hydrogen peroxide to generate oxygen based on Fenton-like reaction, and effectively increased the level of intracellular O 2 with the assistance of 3-bromopyruvate, a cell respiratory inhibitor. The structure and composition of HSCCMBC were characterized by transmission electron microscopy, X-ray photoelectron spectroscopy, X-ray diffraction, infrared spectroscopy, etc. Oxygen probe RDPP was used to investigate the oxygen level inside and outside the cell, and hydroxyl radical probe tetramethylbenzidine was used to investigate the Fenton-like reaction ability. The immunofluorescence method investigated the expression of various immune markers and hypoxia-inducing factors in vitro and in vivo after treatment. In vitro and in vivo experiments indicate that HSCCMBC is an excellent antitumor agent and is expected to be a candidate drug for antitumor immunotherapy.

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“…[29] Chemodynamic therapy (CDT) represents a novel antitumor strategy, which converts low-reactive H 2 O 2 into highly toxic •OH via Fenton or Fenton-like reactions to induce tumor cell death. [30,31] CaO 2 NPs can be combined with Fenton reagent to produce a large amount of H 2 O 2 to assist the therapy. [32] Many other emerging therapies have been developed based on the principles of CDT.…”

Section: Introductionmentioning

confidence: 99%

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

Liu

Wang

et al. 2023

Advanced Therapeutics

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Nano‐CaO2, with its multifunctional properties, has emerged as a promising candidate for tumor therapy. Its ability to release Ca2+ and H2O2 into the tumor microenvironment has positively modulated abnormal calcium signaling and kinetic therapy. Moreover, the indirectly produced O22− by CaO2 can alleviate hypoxic conditions. On the one hand, the accumulation of Ca2+ can lead to various tumor cell apoptosis events, such as calcium overload and tumor calcification. On the other hand, the released H2O2 can convert into more toxic reactive oxygen species (ROS) via exogenous stimulation and endogenous regulation, thereby making nano‐CaO2 a versatile tool in modern medicine, exhibiting its invaluable and irreplaceable medical value in tumor therapy. Hence, a comprehensive review of the recent advances in the nano‐CaO2 platform is imperative. This review provides an overview of the conventional synthesis strategies for nano‐CaO2. It elucidates the potential role of the nano‐CaO2 nanoplatforms in various tumor treatment strategies, including monotherapy and combination therapy, in detail. Given the remarkable outcomes achieved to date and the challenges that of future clinical translation, this work predicts the future research directions. This review will encourage further development of the metal oxide nanomedicine family, epitomized by nano‐CaO2.

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Research Progress on Improving the Efficiency of CDT by Exacerbating Tumor Acidification

Cited by 16 publications

References 168 publications

Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer

Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer

Immunogenic Cell Death Induction and Oxygenation by Multifunctional Hollow Silica/Copper-Doped Carbon Dots

Composite Nanoplatforms Based on Nanocalcium Peroxide for Cancer Treatment: From Monotherapy to Combination Therapy

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