Research Progress of TPX2 on Spindle Assembly and Tumor

Abstract

TPX2 is a conserved microtubule-associated protein that plays an important role in regulating cell cycle and mitosis. TPX2 promotes mitotic TPX2 promotes mitotic spindle assembly in a RanGTP-dependent manner, and its overexpression interferes with spindle microtubule formation, resulting in genomic TPX2 is overexpressed in breast cancer, cervical cancer, pancreatic cancer, and other malignant tumors, which promotes tumorigenesis by TPX2 is overexpressed in breast cancer, cervical cancer, pancreatic cancer, and other malignant tumors, which promotes tumorigenesis by leading to abnormal centrosome amplification, aneuploid formation and malignant transformation of cells. Blocking TPX2 expression inhibits tumor cell growth. This paper reviews the molecular structure of TPX2, this paper reviews the molecular structure of TPX2, its role in spindle assembly and its effects on tumor proliferation, invasion and apoptosis, to provide new ideas for TPX2 in tumor diagnosis and clinical target therapy.