Research progress of stem cell therapy for endometrial injury

Cen, Juan; Zhang, Yichen; Bai, Yindu; Ma, Shenqian; Zhang, Chuan; Jin, Lin; Duan, Shaofeng; Du, Yanan; Guo, Yuanqiang

doi:10.1016/j.mtbio.2022.100389

Cited by 14 publications

(15 citation statements)

References 184 publications

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“…The issues that need to be considered in stem cell transplantation are the administration method, time, and dosage 252 . Research has shown that multiple doses have better therapeutic effects than single doses 253,254 . In addition to intravenous infusion and tracheal delivery, inhalation is a milder and painless method.…”

Section: Therapeutic Potential Of Lung Regeneration In Lung Diseasementioning

confidence: 99%

“…252 Research has shown that multiple doses have better therapeutic effects than single doses. 253,254 In addition to intravenous infusion and tracheal delivery, inhalation is a milder and painless method. However, it is necessary to consider the decrease in cell activity of stem cells as they pass through the respiratory tract.…”

Section: Clinical and Potential Therapeutic Interventions In Ardsmentioning

confidence: 99%

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Lung regeneration: diverse cell types and the therapeutic potential

Chen,

Li,

et al. 2024

MedComm

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Lung tissue has a certain regenerative ability and triggers repair procedures after injury. Under controllable conditions, lung tissue can restore normal structure and function. Disruptions in this process can lead to respiratory system failure and even death, causing substantial medical burden. The main types of respiratory diseases are chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and acute respiratory distress syndrome (ARDS). Multiple cells, such as lung epithelial cells, endothelial cells, fibroblasts, and immune cells, are involved in regulating the repair process after lung injury. Although the mechanism that regulates the process of lung repair has not been fully elucidated, clinical trials targeting different cells and signaling pathways have achieved some therapeutic effects in different respiratory diseases. In this review, we provide an overview of the cell type involved in the process of lung regeneration and repair, research models, and summarize molecular mechanisms involved in the regulation of lung regeneration and fibrosis. Moreover, we discuss the current clinical trials of stem cell therapy and pharmacological strategies for COPD, IPF, and ARDS treatment. This review provides a reference for further research on the molecular and cellular mechanisms of lung regeneration, drug development, and clinical trials.

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Section: Therapeutic Potential Of Lung Regeneration In Lung Diseasementioning

confidence: 99%

Section: Clinical and Potential Therapeutic Interventions In Ardsmentioning

confidence: 99%

Lung regeneration: diverse cell types and the therapeutic potential

Chen,

Li,

et al. 2024

MedComm

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“…Loss of endometrial stem cells and substantial change in the tissue microenvironment are considered to be the main cause for pathological uterine regeneration ( 14 ). Analogous to the “seed and soil” theory, the function of endometrial stem cells is thought to be limited largely by the microenvironment of the repair site ( 15 ). Harnessing the endogenous stem cells and constructing a favorable microenvironment are thereby expected to achieve functional uterine regeneration ( 14 , 15 ).…”

Section: Introductionmentioning

confidence: 99%

“…Analogous to the "seed and soil" theory, the function of endometrial stem cells is thought to be limited largely by the microenvironment of the repair site (15). Harnessing the endogenous stem cells and constructing a favorable microenvironment are thereby expected to achieve functional uterine regeneration (14,15). As an important component of the tissue microenvironment, extracellular matrix (ECM) contains intrinsic biochemical and mechanical cues that can regulate cellular phenotype and function in response to various physiological and pathological stimuli (16), particularly induction of chemotaxis of lineage-directed progenitor cells (17)(18)(19).…”

Section: Introductionmentioning

confidence: 99%

Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Zhao,

Da,

Wang

et al. 2023

Sci. Adv.

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The recurrence rate for severe intrauterine adhesions is as high as 60%, and there is still lack of effective prevention and treatment. Inspired by the nature of uterus, we have developed a bilayer scaffold (ECM-SPS) with biomimetic heterogeneous features and extracellular matrix (ECM) microenvironment of the uterus. As proved by subtotal uterine reconstruction experiments, the mechanical and antiadhesion properties of the bilayer scaffold could meet the requirement for uterine repair. With the modification with tissue-specific cell–derived ECM, the ECM-SPS had the ECM microenvironment signatures of both the endometrium and myometrium and exhibited the property of inducing stem cell–directed differentiation. Furthermore, the ECM-SPS has recruited more endogenous stem cells to promote endometrial regeneration at the initial stage of repair, which was accompanied by more smooth muscle regeneration and a higher pregnancy rate. The reconstructed uterus could also sustain normal pregnancy and live birth. The ECM-SPS may thereby provide a potential treatment for women with severe intrauterine adhesions.

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“…На фоне ВМС в эндометрии развивается фиброз: нормальная (гормонально отзывчивая) ткань эндометрия замещается атрофической, аваскулярной и невосприимчивой рубцовой тканью [10,13,44]. Как поврежденные участки слизистой оболочки матки, так и окружаю щий его эндометрий отличаются от нормального [45].…”

Section: Introductionunclassified

Intrauterine adhesions: from pathogenesis to effective coping technologies

et al. 2023

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Intrauterine adhesions (IUDs) are one of the unresolved and unsolved problems of modern reproductive medicine worldwide. Adhesive lesions lead to partial or complete obliteration of the uterine cavity and/or cervical canal. The main clinical manifestations of IUDs are menstrual irregularities, cyclical pain, infertility and other various reproductive disorders. Reproductive outcomes in women with IUDs remain poorly understood and difficult to verify. At the same time, there is currently no understanding of the basic mechanisms of IUD development, including the processes explaining the failures of the above complications. The problem of overcoming IUD recurrences after adhesiolysis remains far from being finally resolved. The gold-standard treatment for IUD is hysteroscopic adhesiolysis, which, however, is associated with a high frequency of complications and relapses, highlighting the need for preventive approaches to the management of IUD. The drugs with enzymatic activity inhibiting abnormal connective tissue include bovhyaluronidase azoximer created by the Russian developers back in 2005. The drug consists of two components – hyaluronidase and azoximer bromide. The former is an enzyme, and the latter is a stabilizer that prolongs the action of hyaluronidase. Several studies have shown that bovhyaluronidase azoximer causes the destruction of intrauterine adhesions and restores the endometrium status in inflammatory pelvic diseases. Due to prolonged antifibrotic effect of bovhyaluronidase, azoximer can be used to treat women with IUDs to reduce the risk of the subsequent development of adhesive process in the uterine cavity.

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Research progress of stem cell therapy for endometrial injury

Cited by 14 publications

References 184 publications

Lung regeneration: diverse cell types and the therapeutic potential

Lung regeneration: diverse cell types and the therapeutic potential

Promotion of uterine reconstruction by a tissue-engineered uterus with biomimetic structure and extracellular matrix microenvironment

Intrauterine adhesions: from pathogenesis to effective coping technologies

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