Research Progress of Selenium-Enriched Foods

Chen, Zhenna; Lu, Yiqing; Dun, Xiaoling; Wang, Xinfa; Wang, Hanzhong

doi:10.3390/nu15194189

Cited by 9 publications

(3 citation statements)

References 117 publications

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“…Bereits 1982 wurde in einer longitudinalen Fall-Kontrollstudie die hohe kardiovaskuläre Mortalität bei Selenmangel beschrieben, die letztlich dazu führte, dass die Autoren sich erfolgreich für eine landesweite Selensupplementation in Finnland einsetzten [28]. Entsprechende Aktivitäten gibt es in den selenarmen Regionen in China, durch eine gezielte Supplementation der Entwicklung von endemischen Erkrankungen der Gelenke und des Herzens entgegenzuwirken [11,29].…”

Section: Gesundheitsrisiken Bei Selenmangelunclassified

Selenoprotein P – die Drehscheibe im Selenstoffwechsel

Stoll,

Gröber,

Schomburg

2024

Zeitschrift für Orthomolekulare Medizin

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ZusammenfassungSelen ist ein essenzielles Spurenelement, das im Körper in Form von Selenoproteinen verschiedene physiologische Funktionen erfüllt. Die Hauptform des Selens im Blutplasma ist das Selenoprotein P (SELENOP). Neben seiner Funktion als wichtigster Transporter im Körper übernimmt es auch Speicher- und Verteilerfunktionen. Eine niedrige Konzentration an SELENOP wurde als Risikofaktor für eine Reihe verschiedener Erkrankungen und generell mit verringerter Lebenserwartung assoziiert. Auch beim Selenmangel gibt es einige Gesundheitsrisiken. Der Ausgleich eines Selendefizits ist relativ einfach und kann durch eine bessere Versorgung erfolgen.

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Section: Gesundheitsrisiken Bei Selenmangelunclassified

Selenoprotein P – die Drehscheibe im Selenstoffwechsel

Stoll,

Gröber,

Schomburg

2024

Zeitschrift für Orthomolekulare Medizin

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“…[ 330 ] H 2 Se, a highly reactive molecule with reducing properties, is a shared metabolite of dietary Se‐compounds and formed from Na 2 SeO 3 via selenodiglutathione through reduction by thiols and NADPH‐dependent reductases and released from selenocysteine by lyase action. [ 331 ] Under hypoxic conditions, H 2 Se accumulation can lead to reductive stress. [ 332 ] However, the half‐life for the oxidation of H 2 Se to elemental Se in air‐saturated water at pH 7 is quite short (≈30 s [ 333 ] ), making the controllable production of H 2 Se technically challenging.…”

Section: Nanomaterials That Manipulating Redox Balance In Cancer Cell...mentioning

confidence: 99%

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

Wu,

Zhou,

et al. 2024

Advanced Science

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Cancer cells typically display redox imbalance compared with normal cells due to increased metabolic rate, accumulated mitochondrial dysfunction, elevated cell signaling, and accelerated peroxisomal activities. This redox imbalance may regulate gene expression, alter protein stability, and modulate existing cellular programs, resulting in inefficient treatment modalities. Therapeutic strategies targeting intra‐ or extracellular redox states of cancer cells at varying state of progression may trigger programmed cell death if exceeded a certain threshold, enabling therapeutic selectivity and overcoming cancer resistance to radiotherapy and chemotherapy. Nanotechnology provides new opportunities for modulating redox state in cancer cells due to their excellent designability and high reactivity. Various nanomaterials are widely researched to enhance highly reactive substances (free radicals) production, disrupt the endogenous antioxidant defense systems, or both. Here, the physiological features of redox imbalance in cancer cells are described and the challenges in modulating redox state in cancer cells are illustrated. Then, nanomaterials that regulate redox imbalance are classified and elaborated upon based on their ability to target redox regulations. Finally, the future perspectives in this field are proposed. It is hoped this review provides guidance for the design of nanomaterials‐based approaches involving modulating intra‐ or extracellular redox states for cancer therapy, especially for cancers resistant to radiotherapy or chemotherapy, etc.

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“…As a crucial cash crop, rice ( Oryza sativa ) is globally recognized for its high yield and extensive cultivation [ 36 ]. Moreover, rice serves as an important source of Se for human consumption, and the Se level in rice determines the Se nutritional status of the Chinese population [ 37 , 38 ].…”

Section: Introductionmentioning

confidence: 99%

High Concentrations of Se Inhibited the Growth of Rice Seedlings

Liu,

Ma,

et al. 2024

Plants

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Selenium (Se) is crucial for both plants and humans, with plants acting as the main source for human Se intake. In plants, moderate Se enhances growth and increases stress resistance, whereas excessive Se leads to toxicity. The physiological mechanisms by which Se influences rice seedlings’ growth are poorly understood and require additional research. In order to study the effects of selenium stress on rice seedlings, plant phenotype analysis, root scanning, metal ion content determination, physiological response index determination, hormone level determination, quantitative PCR (qPCR), and other methods were used. Our findings indicated that sodium selenite had dual effects on rice seedling growth under hydroponic conditions. At low concentrations, Se treatment promotes rice seedling growth by enhancing biomass, root length, and antioxidant capacity. Conversely, high concentrations of sodium selenite impair and damage rice, as evidenced by leaf yellowing, reduced chlorophyll content, decreased biomass, and stunted growth. Elevated Se levels also significantly affect antioxidase activities and the levels of proline, malondialdehyde, metal ions, and various phytohormones and selenium metabolism, ion transport, and antioxidant genes in rice. The adverse effects of high Se concentrations may directly disrupt protein synthesis or indirectly induce oxidative stress by altering the absorption and synthesis of other compounds. This study aims to elucidate the physiological responses of rice to Se toxicity stress and lay the groundwork for the development of Se-enriched rice varieties.

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Research Progress of Selenium-Enriched Foods

Cited by 9 publications

References 117 publications

Selenoprotein P – die Drehscheibe im Selenstoffwechsel

Selenoprotein P – die Drehscheibe im Selenstoffwechsel

Nanomaterials‐Induced Redox Imbalance: Challenged and Opportunities for Nanomaterials in Cancer Therapy

High Concentrations of Se Inhibited the Growth of Rice Seedlings

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