Research progress of physical transdermal enhancement techniques in tumor therapy

Han, Weiqiang; Liu, Fengyu; Liu, Guoxin; Li, Hongjuan; Xu, Yongqian; Sun, Shiguo

doi:10.1039/d2cc06219d

Cited by 6 publications

(1 citation statement)

References 253 publications

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“…This technique employs an internally cooled radiofrequency catheter inserted into the target nodule under ultrasound guidance to generate heat through alternating current. This heat induces irreversible tissue damage, resulting in coagulation necrosis [ 10 , 11 ]. TA offers several advantages over traditional treatments, including higher precision, minimal invasiveness, quicker recovery, and repeatability [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of ultrasound-guided thermal ablation of graves’ disease: a retrospective cohort study

Cai,

Luo,

Wang

et al. 2024

Thyroid Res

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Background Ultrasound-guided thermal ablation (TA) has emerged as a robust therapeutic approach for treating solid tumors in multiple organs, including the thyroid. Yet, its efficacy and safety profile in the management of Graves’ Disease (GD) remains to be definitively established. Methods A retrospective study was conducted on 50 GD patients treated with TA between October 2017 and December 2021. Key metrics like thyroid volume, volume reduction rate (VRR), thyroid hormones, and basal metabolic rate (BMR) were evaluated using paired Wilcoxon tests. Results The intervention of ultrasound-guided TA yielded a statistically significant diminution in total thyroid volume across all postoperative follow-up intervals—1, 3, 6, and 12 months—relative to pre-intervention baselines (p < 0.001). The median VRR observed at these time points were 17.5%, 26.5%, 34.4%, and 39.8%, respectively. Euthyroid status was corroborated in 96% of patients at the one-year follow-up milestone. Transient tachycardia and dysphonia were observed in three patients, while a solitary case of skin numbness was noted. Crucially, no instances of enduring injury to the recurrent laryngeal nerve (RLN) were documented. Conclusions Our investigation substantiates ultrasound-guided TA as a pragmatic, well-tolerated, and safe therapeutic modality for GD. It effectively improves symptoms of hyperthyroidism, engenders a substantial reduction in thyroid volume, and restores thyroid hormone and BMR to physiological levels. Given its favorable safety profile, enhanced cosmetic outcomes, and minimally invasive nature, ultrasound-guided TA is a compelling alternative to thyroidectomy for GD patients.

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Section: Introductionmentioning

confidence: 99%

Efficacy and safety of ultrasound-guided thermal ablation of graves’ disease: a retrospective cohort study

Cai,

Luo,

Wang

et al. 2024

Thyroid Res

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A Fully Integrated Conformal Wearable Ultrasound Patch for Continuous Sonodynamic Therapy

Zou,

Luo,

Zhuang

et al. 2024

Advanced Materials

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Cancer treatment is a continuous process, that the current therapy cannot meet the requirement well, including radiotherapy and chemotherapy. Wearable ultrasound device has the potential for continuous sonodynamic therapy due to its portability. However, the miniaturization of ultrasonic probe, system integration of device, and the strategy of continuous treatment are still urgent issues to be addressed. Herein, a portable wearable antitumor system is introduced, which utilizes a custom‐developed multiplexed ultrasonic patch array (CWUS Patch) to accurately focus ultrasound on the lesion site and controllably stimulate sonosensitizer to produce a large amount of toxic reactive oxygen species (ROS). The system enables dynamic control of the ultrasound patches and allows real‐time adjustments to optimize their performance in various applications, providing greater flexibility and precision in healthcare technology. Furthermore, the excellent penetration property of ultrasound into tumor tissues that induce synchronous apoptosis of tumor cells from the inside out is verified through a mouse model of breast cancer. This fully integrated conformal wearable ultrasound system provides a promising approach to noninvasively, continuously, and efficiently treat deep tumors.

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Fluorocarbon Modified Chitosan to Enable Transdermal Immunotherapy for Melanoma Treatment

Zhuang

Chao

et al. 2023

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Despite the rapid development of the immune checkpoint blockade (ICB) in melanoma treatment, the immunosuppressive tumor microenvironment (TME) still hinders the efficacy of immunotherapy. Recently, using agonists to modulate the TME have presented promising clinical responses in combination with ICB therapies. However, local intratumoral injection as the commonly used administration route for immune agonists would lead to low patient compliance. Herein, it is demonstrated that fluorocarbon modified chitosan (FCS) can self‐assemble with immune adjuvant polyriboinosinic:polyribocytidylic acid (poly(I:C)), forming nanoparticles that can penetrate through cutaneous barriers to enable transdermal delivery. FCS/poly(I:C) can efficiently activate various types of cells presented on the transdermal route (through the skin into the TME), leading to IRF3‐mediated IFN‐β induction in the activated cells for tumor repression. Furthermore, transdermal FCS/poly(I:C) treatment can significantly magnify the efficacy of the programmed cell death protein 1 (PD‐1) blockade in melanoma treatment through activating the immunosuppressive TME. This study approach offered an attractive transdermal approach in combined with ICB therapy for combined immunotherapy, particularly suitable for melanoma treatment.

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Research progress of physical transdermal enhancement techniques in tumor therapy

Abstract: The advancement and popularity of transdermal drug delivery (TDD) based on physical transdermal enhancement technique (PTET) has opened a new paradigm for local tumor treatment. The drug can be directly...

Cited by 6 publications

References 253 publications

Efficacy and safety of ultrasound-guided thermal ablation of graves’ disease: a retrospective cohort study

Efficacy and safety of ultrasound-guided thermal ablation of graves’ disease: a retrospective cohort study

A Fully Integrated Conformal Wearable Ultrasound Patch for Continuous Sonodynamic Therapy

Fluorocarbon Modified Chitosan to Enable Transdermal Immunotherapy for Melanoma Treatment

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