Research progress of PBX1 in developmental and regenerative medicine

Chen, Hao; Zhuyuan, YU; Niu, Ye; Wang, Litian; Xu, Kan; Liu, Jinyu

doi:10.7150/ijms.80262

Cited by 1 publication

(3 citation statements)

References 74 publications

(88 reference statements)

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“…1,3 TALE subfamily includes pre-B cell leukemia homeobox (PBX) proteins and myeloid ecotropic insertion site (MEIS) proteins, which form complexes with HOX proteins and function as cofactors of HOX proteins. 1,[3][4][5][6] The homeobox protein MEIS2 belongs to the MEIS family. MEIS2 acts as a key transcription factor that regulates cell differentiation and embryonic development.…”

Section: Introductionmentioning

confidence: 99%

“…Among them, the TALE (three‐amino‐acid loop extension) is an atypical subfamily as the proteins of which have three extra amino acids residues proline‐tyrosine‐proline in its first loop region 1,3 . TALE subfamily includes pre‐B cell leukemia homeobox (PBX) proteins and myeloid ecotropic insertion site (MEIS) proteins, which form complexes with HOX proteins and function as cofactors of HOX proteins 1,3–6 …”

Section: Introductionmentioning

confidence: 99%

“… 1 , 3 TALE subfamily includes pre‐B cell leukemia homeobox (PBX) proteins and myeloid ecotropic insertion site (MEIS) proteins, which form complexes with HOX proteins and function as cofactors of HOX proteins. 1 , 3 , 4 , 5 , 6 …”

Section: Introductionmentioning

confidence: 99%

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MEIS2 suppresses breast cancer development by downregulating IL10

Xiao,

Liu,

Sun

et al. 2024

Cancer Reports

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BackgroundBreast cancer (BC) is the most commonly diagnosed female cancer. Homeobox protein MEIS2, a key transcription factor, is involved in the regulation of many developmental and cellular processes. However, the role of MEIS2 in the development of breast cancer is still unclear.AimsWe aimed to examine the role of myeloid ecotropic insertion site (MEIS2) in breast cancer and the association of MEIS2 with breast cancer clinical stages and pathological grades. We revealed the underlying mechanism by which MEIS2 affected breast cancer cell growth and tumor development.Methods and ResultsUsing human BC cell lines, clinical samples and animal xenograft model, we reveal that MEIS2 functions as a tumor suppressor in breast cancer. The expression of MEIS2 is inversely correlated with BC clinical stages and pathological grades. MEIS2 knockdown (MEIS2‐KD) promotes while MEIS2 overexpression suppresses breast cancer cell proliferation and tumor development in vitro and in animal xenograft models, respectively. To determine the biological function of MEIS2, we screen the expression of a group of MEIS2 potential targeting genes in stable‐established cell lines. Results show that the knockdown of MEIS2 in breast cancer cells up‐regulates the IL10 expression, but MEIS2 overexpression opposed the effect on IL10 expression. Furthermore, the suppressive role of MEIS2 in breast cancer cell proliferation is associated with the IL10 expression and myeloid cells infiltration.ConclusionOur study demonstrates that the tumor suppressor of MEIS2 in breast cancer progression is partially via down regulating the expression of IL10 and promoting myeloid cells infiltration. Targeting MEIS2 would be a potentially therapeutic avenue for BC.

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