Research progress of natural medicine Astragalus mongholicus Bunge in treatment of myocardial fibrosis

Ren, Chunzhen; Zhao, Xinke; Li, Kai; Wang, Lirong; Chen, Qilin; Jiang, Hugang; Gao, Xiang; Lv, Xinfang; Zhi, Xiaodong; Wu, Xue Shen; Li, Yingdong

doi:10.1016/j.jep.2022.116128

Cited by 15 publications

(14 citation statements)

References 48 publications

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“…Astragaloside IV, a cycloartane tetracyclic triterpene saponin in AM, is the quality control marker recorded by the Chinese Pharmacopoeia (2020 edition) . Flavonoids, with 2-phenylchromone as the framework, are another major bioactive component of AM . Thirteen flavonoids were found in AA-NPs, such as calycosin, calycosin-7- O -β- d -glucoside, formononetin, and ononin, possessing similar fragmentation pathways.…”

Section: Resultsmentioning

confidence: 99%

“…Myocardial fibrosis is a common pathological process of several cardiovascular diseases, which is often accompanied by decreased cardiac function . Previous reports have confirmed that the AM–AS herb pair has a significant effect on the treatment of myocardial fibrosis . To verify the therapeutic efficacy of AA-NPs isolated from the AM–AS codecoction, isoprenaline-induced myocardial fibrosis was established and applied.…”

Section: Resultsmentioning

confidence: 99%

“…1 Flavonoids, with 2-phenylchromone as the framework, are another major bioactive component of AM. 7 Thirteen flavonoids were found in AA-NPs, such as calycosin, calycosin-7-O-β-D-glucoside, formononetin, and ononin, possessing similar fragmentation pathways. The encapsulation and release of eight components in AA-NPs were further investigated using ultrafiltration−centrifugation and dialysis methods, respectively.…”

Section: Chemical Compositions Of Aa-npsmentioning

confidence: 95%

“…6 In recent years, the AM−AS codecoction has been used as a natural medicine to prevent and treat myocardial fibrosis. 7 An understanding of the mechanism of the AM−AS codecoction in the treatment of myocardial fibrosis will further enrich the basic research of its pharmacodynamic substances. Decoction is the preferred dosage form for treating complex diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Given the side effects of long-term use of statins, there is a need to develop safe and effective drugs with low toxicity to benefit patients with myocardial fibrosis . In recent years, the AM–AS codecoction has been used as a natural medicine to prevent and treat myocardial fibrosis . An understanding of the mechanism of the AM–AS codecoction in the treatment of myocardial fibrosis will further enrich the basic research of its pharmacodynamic substances.…”

Section: Introductionmentioning

confidence: 99%

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Insights into the Mechanism of Supramolecular Self-Assembly in the Astragalus membranaceus–Angelica sinensis Codecoction

Liang,

Bi,

Zhou

et al. 2023

ACS Appl. Mater. Interfaces

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Astragalus membranaceus (Fisch.) Bge. (AM) and Angelica sinensis (Oliv.) Diels (AS) constitute a classic herb pair in prescriptions to treat myocardial fibrosis. To date, research on the AM−AS herb pair has mainly focused on the chemical compositions associated with therapeutic efficacy. However, supermolecules actually exist in herb codecoctions, and their selfassembly mechanism remains unclear. In this study, supermolecules originating from AM−AS codoping reactions (AA-NPs) were first reported. The chemical compositions of AA-NPs showed a dynamic self-assembly process. AA-NPs with different decoction times had similar surface groups and amorphous states; however, the size distributions of these nanoparticles might be different. Taking the interaction between Z-ligustilide and astragaloside IV as an example to understand the self-assembly mechanism of AA-NPs, it was found that the complex could be formed with a molar ratio of 2:1. Later, AA-NPs were proven to be effective in the treatment of myocardial fibrosis both in vivo and in vitro, the in-depth mechanisms of which were related to the recovery of cardiac function, reduced collagen deposition, and inhibition of the endothelial-to-mesenchymal transition that occurred in the process of myocardial fibrosis. Thus, AA-NPs may be the chemical material basis of the molecular mechanism of the AM−AS decoction in treating isoproterenol-induced myocardial fibrosis. Taken together, this work provides a supramolecular strategy for revealing the interaction between effective chemical components in herb-pair decoctions.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%