Research progress of nanomaterial-mediated photodynamic therapy in tumor treatment

Yan, Zhihui; Qin, Chuyu; Zhao, Chuanxiang; Fang, Zhengzou

doi:10.1007/s11051-020-05030-2

Cited by 9 publications

(10 citation statements)

References 71 publications

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“…Generally, NPs with diameters of 50−100 nm are suitable for prolonging blood circulation and can effectively accumulate in tumors through the EPR effect. 54 As a phototherapeutic agent targeting tumors through intravenous injection, BITT@BSA−DSP should be an improved choice. Different feeding mass ratios of BITT to BSA with values of 5%, 10%, 15%, and 20% (w/w) were measured to determine their effects on the diameter, ROS generation capability, and photothermal conversion performance of the NPs (Figure S4 and Table S1).…”

Section: Resultsmentioning

confidence: 99%

“…As shown in Figure C and D and Table S1, the DLS and TEM data showed that the average diameter of BITT@BSA–DSP NPs was 70.2 ± 22.0 nm (polydispersity index (PDI): 0.13). Generally, NPs with diameters of 50–100 nm are suitable for prolonging blood circulation and can effectively accumulate in tumors through the EPR effect . As a phototherapeutic agent targeting tumors through intravenous injection, BITT@BSA–DSP should be an improved choice.…”

Section: Resultsmentioning

confidence: 99%

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Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates

et al. 2022

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The implementation of cisplatin-based neoadjuvant chemotherapy (NAC) plays a key role in conjunction with surgical resection in preventing bladder cancer progression and recurrence. However, the significant dose-dependent toxic side effects of NAC are still a major challenge. To solve this problem, we developed a photoenhanced cancer chemotherapy (PECC) strategy based on AIEgen ((E)-3-(2-(2-(5-(4-(diphenylamino)phenyl)thiophen-2-yl)vinyl)-1,1-dimethyl-1H-3λ4-benzo[e]indol-3-yl)propane-1-sulfonate), which is abbreviated as BITT. Multifunctional BITT@BSA–DSP nanoparticles (NPs) were employed with an albumin-based nanocarrier decorated with the cisplatin(IV) prodrug and loaded to produce strong near-infrared fluorescence imaging (NIR FLI), and they exhibited good photoenhancement performance via photodynamic therapy (PDT) and photothermal therapy (PTT). In vitro results demonstrated that BITT@BSA–DSP NPs could be efficiently taken up by bladder cancer cells and reduced to release Pt (II) under reductase, ensuring the chemotherapy effect. Furthermore, both in vitro and in vivo evaluation verified that the integration of NIR FL imaging-guided PECC efficiently promoted the sensitivity of bladder cancer to cisplatin chemotherapy with negligible side effects. This work provides a promising strategy to enhance the sensitivity of multiple cancers to chemotherapy drugs and even achieve effective treatments for drug-resistant cancers.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates

et al. 2022

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“…PDT has been studied as an immunogenic cell death (ICD) inducer for eliciting direct tumor-killing effects through the creation of tumor antigen pools with danger signals that promote cancer-specific immunity [20]. Photosensitizers (PS) can produce reactive oxygen species (ROS) in response to exposure to a certain wavelength, which can then kill surrounding cancer cells by necrotic or apoptotic cell death [20]. Owing to the highly enriched distinctive physical and chemical characteristics, CDs have been applied in the synergistic treatment of PDT and immunotherapy [21].…”

Section: Immunotherapy Applications Of Carbon Dots Pdtmentioning

confidence: 99%

“…In addition to their multicolored emission, tunable optical properties, and outstanding photostability, CDs can also be used as efficient tools for tumor therapy owing to their easy surface functionalization and excellent biocompatibility [14,19]. On the one side, CDs can be employed as phototherapy agents, including photodynamic therapy (PDT) and photothermal therapy (PTT) [20,21]. On the other side, the rational design would confer CDs the properties of nanoenzymes or chemotherapeutic agents involved in tumor chemodynamic therapy (CDT) [22].…”

Section: Introductionmentioning

confidence: 99%

The application of carbon dots in tumor immunotherapy: researches and prospects

Hong

Cai

Abbas

et al. 2023

Preprint

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Since the rapid development of nanomedicine in oncotherapy, multiple nanomaterials are adopted to regulate the immune system in cancer individuals. Tumor immunotherapy enhances the immune function of patients to achieve the purpose of killing tumor cells by utilizing the organism immune mechanism. As emerging inorganic carbon nanoparticles, carbon dots (CDs) have been found as photosensitizers, vaccines, immunoadjuvants, and so on for cancer treatment due to their unique structure and property, such as effective platforms for drug delivery, immunomodulation, and phototherapy. In this review, we mainly discuss the recent application of CDs in tumor immunotherapy and the prospects of CDs in the field of immune medicine. By assessing the achievements and challenges of CDs in tumor immunotherapy, our review would provide mechanistic insights into the evolution of future nanomedicine.

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“…The chemokine receptors dysregulated in HSCs contain CXC chemokine receptor 3 (CXCR3); C–C chemokine receptor (CCR) family, including CCR5 and CCR7( Seki et al, 2009 ). The chemokine family chain in HSCs contains the chemokine ligand (CCL) family, which includes CCL2, CCL3, and CCL5; in addition, the CXC chemokine ligand (CXCL) family contains CXCL1 and CXCL8–CXCL10 ( Weiskirchen and Tacke 2014 ; Yan et al, 2020 ). Generally, the chemokines bind to their receptors to promote HSC migration and ECM generation.…”

Section: Introductionmentioning

confidence: 99%

Crosstalk Between Autophagy and Innate Immunity: A Pivotal Role in Hepatic Fibrosis

et al. 2022

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Liver fibrosis is a repair process of chronic liver injuries induced by toxic substances, pathogens, and inflammation, which exhibits a feature such as deposition of the extracellular matrix. The initiation and progression of liver fibrosis heavily relies on excessive activation of hepatic stellate cells (HSCs). The activated HSCs express different kinds of chemokine receptors to further promote matrix remodulation. The long-term progression of liver fibrosis will contribute to dysfunction of the liver and ultimately cause hepatocellular carcinoma. The liver also has abundant innate immune cells, including DCs, NK cells, NKT cells, neutrophils, and Kupffer cells, which conduct complicated functions to activation and expansion of HSCs and liver fibrosis. Autophagy is one specific type of cell death, by which the aberrantly expressed protein and damaged organelles are transferred to lysosomes for further degradation, playing a crucial role in cellular homeostasis. Autophagy is also important to innate immune cells in various aspects. The previous studies have shown that dysfunction of autophagy in hepatic immune cells can result in the initiation and progression of inflammation in the liver, directly or indirectly causing activation of HSCs, which ultimately accelerate liver fibrosis. Given the crosstalk between innate immune cells, autophagy, and fibrosis progression is complicated, and the therapeutic options for liver fibrosis are quite limited, the exploration is essential. Herein, we review the previous studies about the influence of autophagy and innate immunity on liver fibrosis and the molecular mechanism to provide novel insight into the prevention and treatment of liver fibrosis.

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Research progress of nanomaterial-mediated photodynamic therapy in tumor treatment

Cited by 9 publications

References 71 publications

Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates

Photo-Enhanced Chemotherapy Performance in Bladder Cancer Treatment via Albumin Coated AIE Aggregates

The application of carbon dots in tumor immunotherapy: researches and prospects

Crosstalk Between Autophagy and Innate Immunity: A Pivotal Role in Hepatic Fibrosis

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