Research progress of miRNA in different depression model samples

Abstract

Depression is a mood disorder characterized by prolonged depressed mood, lack of interest and pleasure, and low self-assessment. The miRNAs, as single-stranded non-coding RNA molecules that can participate in post-transcriptional regulation of gene expression, regulate physiological processes by degrading mRNAs or inhibiting the translation of their target genes to achieve gene silencing. Numerous studies have revealed an in-depth understanding of depression-related miRNA changes and the role they play in the pathogenesis of depression, and miRNAs have received widespread attention as therapeutic targets. This review summarizes the expression of miRNAs in different depression samples (patients, rats, and mice) and the corresponding regulatory pathways. The analysis revealed the existence of miRNAs with consistent expression trends in different samples, and the discovery of these miRNAs provides new insights into their use as therapeutic targets in depression.