Research Progress of MicroRNAs and Related Factors in the Pathogenesis of Lichen Planus

Abstract

More evidences show that microRNAs play an important role in the pathogenesis of inflammation and autoimmune diseases including Lichen planus, and are an attractive therapeutic target. MicroRNA family plays an important role in the regulation of gene expression, which involves cell proliferation, apoptosis, growth, differentiation and metabolism, vascularization, immune response and other biological processes. The changes of expression profile and expression level are closely related to the occurrence and development of many diseases, such as tumor, inflammatory disease and autoimmune disease relevant. However, there are few reports on microRNA in the pathogenesis of LP. This review summarizes the research advance of microRNAs (microRNAs -137, microRNAs -125b, microRNAs -138, microRNAs -27b, microRNAs -203) and their downstream proteins in LP.

Downregulated Serum Exosomal miR-451a Expression Correlates With Renal Damage and Its Intercellular Communication Role in Systemic Lupus Erythematosus

“…For example, microRNAs (miRNAs or miRs), exosomes and exosomal miRNAs can all serve as biomarkers in autoimmune diseases (4). Published evidence indicates that miRNAs participate in different immune responses (5,6), which makes them crucial candidates for use as diagnostic markers and treatment targets (7,8). Increasing evidence suggests that the expression characteristics of serum miRNAs makes them possible biomarkers of autoimmune diseases, including SLE, and therefore they should be exploited for the betterment of humankind (9,10).…”