Research Progress of Long Non-coding RNAs in Spinal Cord Injury

Abstract

Spinal cord injury (SCI) can result in a partial or complete loss of motor and sensory function below the injured segment, which has a significant impact on patients' quality of life and places a significant social burden on them. Long non-coding RNA (LncRNA) is a 200–1000 bp non-coding RNA that has been shown to have a key regulatory role in the progression of a variety of neurological illnesses. Many studies have demonstrated that differentially expressed LncRNAs following spinal cord injury can participate in inflammatory damage, apoptosis, and nerve healing by functioning as competitive endogenous RNA (ceRNA); at the same time, it has a significant regulatory effect on sequelae such neuropathic pain. As a result, we believe that LncRNAs could be useful as a molecular regulatory target in the diagnosis, treatment, and prognosis of spinal cord injury.

LncRNA TSIX aggravates spinal cord injury by regulating the PI3K/AKT pathway via the miR‐532‐3p/DDOST axis

“…[8,9] Researchers have revealed the critical roles of lncRNAs in SCI. [10,11] X-inactive-specific transcript (XIST) refers to a class of noncoding RNAs implicated in the differentiation and proliferation of cells. [12] Previous studies have revealed that XIST promotes neurological repair post-SCI by binding to miR-32-5p to modulate Notch-1.…”