Research Progress of Heavy Ion Radiotherapy for Non-Small-Cell Lung Cancer

Liang, Siqi; Zhou, Guangming; Hu, Wentao

doi:10.3390/ijms23042316

Cited by 10 publications

(4 citation statements)

References 96 publications

(107 reference statements)

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“…Thus, the application of “CIRT combining immunotherapy” shows a very promising prospect. Currently, the combination of CIRT and immunotherapy has made some progress in NSCLC ( 62 ), and this combined approach is increasingly being seen as an effective cancer treatment modality.…”

Section: The Combination Of Rt and Immunotherapymentioning

confidence: 99%

A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

Zheng,

Yang,

et al. 2024

Front. Immunol.

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Renal cell carcinoma (RCC) is considered radio- and chemo-resistant. Immune checkpoint inhibitors (ICIs) have demonstrated significant clinical efficacy in advanced RCC. However, the overall response rate of RCC to monotherapy remains limited. Given its immunomodulatory effects, a combination of radiotherapy (RT) with immunotherapy is increasingly used for cancer treatment. Heavy ion radiotherapy, specifically the carbon ion radiotherapy (CIRT), represents an innovative approach to cancer treatment, offering superior physical and biological effectiveness compared to conventional photon radiotherapy and exhibiting obvious advantages in cancer treatment. The combination of CIRT and immunotherapy showed robust effectiveness in preclinical studies of various tumors, thus holds promise for overcoming radiation resistance of RCC and enhancing therapeutic outcomes. Here, we provide a comprehensive review on the biophysical effects of CIRT, the efficacy of combination treatment and the underlying mechanisms involved in, as well as its therapeutic potential specifically within RCC.

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Section: The Combination Of Rt and Immunotherapymentioning

confidence: 99%

A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

Zheng,

Yang,

et al. 2024

Front. Immunol.

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“…FLASH-RT maintains local tumor control while reducing normal tissue toxicity compared with conventional RT [25][26][27][28][29]. Furthermore, the application of particle beams in proton and heavy ion RT interests radiologists due to their potential to minimize normal tissue damage [30,31]. Despite the technological efforts, minimizing radiation injury remains a challenge [32].…”

Section: Introductionmentioning

confidence: 99%

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

Ning,

Chen,

Zeng

et al. 2024

Int. J. Biol. Sci.

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Radiotherapy (RT) stands as the primary treatment for tumors, but it inevitably causes damage to normal cells. Consequently, radiation injury is a crucial consideration for radiation oncologists during therapy planning. Cell death including apoptosis, autophagy, pyroptosis, ferroptosis, and necroptosis play significant roles in tumor treatment. While previous studies elucidated the induction of apoptosis and autophagy by ionizing radiation (IR), recent attention has shifted to pyroptosis, ferroptosis, and necroptosis, revealing their effects induced by IR. This review aims to summarize the strategies employed by IR, either alone or in combination therapy, to induce pyroptosis, ferroptosis, and necroptosis in radiation injury. Furthermore, we explore their effects and molecular pathways, shedding light on their roles in radiation injury. Finally, we summarize the regulative agents for these three types of cell death and their mechanisms. In summary, optimizing radiation dose, dose rate, and combined treatment plans to minimize radiation damage and enhance the killing effect of RT is a key focus.

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“…In its early stages, cancer often presents with no notable symptoms. Upon diagnosis, the treatment typically includes surgery [ 1 ], radiotherapy [ 2 ], chemotherapy [ 3 ], targeted therapy [ 4 ], and immunotherapy [ 5 ]. Regardless of the treatment approach, early diagnosis is crucial for its treatment [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Label-Free Ratiometric Homogeneous Electrochemical Strategy Based on Exonuclease III-Aided Signal Amplification for Facile and Rapid Detection of miR-378

Fan,

Wang,

Wang

et al. 2024

International Journal of Analytical Chemistry

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MiR-378 is abnormally expressed in various cancers, such as hepatocellular carcinoma, renal cell carcinoma, and nonsmall cell lung cancer. Here, we developed a label- and immobilization-free ratiometric homogeneous electrochemical strategy based on exonuclease III (Exo III) for the facile and rapid determination of miR-378. Two 3′-protruding hairpin DNA probes (HPs) are designed in this strategy. Doxorubicin (DOX) and potassium ferrocyanide (Fe2+) were used as label-free probes to produce a response signal (IDOX) and a reference signal (IFe2+) in the solution phase. When no target was present in the solution, the HP was stable, most of the DOX was intercalated in the stem of the HP, and the diffusion rate of DOX was significantly reduced, resulting in reduced electrochemical signal response. When miR-378 was present, double-cycle signal amplification triggered by Exo III cleavage was initiated, ultimately disrupting the hairpin structures of HP1 and HP2 and releasing a large amount of DOX into the solution, yielding a stronger electrochemical signal, which was low to 50 pM. This detection possesses excellent selectivity, demonstrating high application potential in biological systems, and offers simple and low-cost electrochemical detection for miR-378.

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Research Progress of Heavy Ion Radiotherapy for Non-Small-Cell Lung Cancer

Cited by 10 publications

References 96 publications

A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

A future directions of renal cell carcinoma treatment: combination of immune checkpoint inhibition and carbon ion radiotherapy

The scheme, and regulative mechanism of pyroptosis, ferroptosis, and necroptosis in radiation injury

Label-Free Ratiometric Homogeneous Electrochemical Strategy Based on Exonuclease III-Aided Signal Amplification for Facile and Rapid Detection of miR-378

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