Research progress of contrast agents for bacterial infection imaging in vivo

Zhang, Yaqing; Hao, Mengqi; Li, Linyao; Luo, Qi; Deng, Siyu; Yang, Yun; Liu, Yan; Fang, Wei; Song, Erqun

doi:10.1016/j.trac.2023.116916

Cited by 7 publications

(3 citation statements)

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…61,62 To this end, developing molecular imaging probes for in vivo detection of bacterial infections is in urgent demand. 63 To date, different imaging modalities, including fluorescence (FL) imaging, photoacoustic (PA) imaging, and magnetic resonance (MR) imaging, have been developed by utilizing the concept of in situ peptide selfassembly. In this section, we focused on the application of in situ peptide assemblies in bacterial infection imaging in recent years.…”

Section: In Situ Peptide Assemblies For Bacterial Infection Imagingmentioning

confidence: 99%

In situ peptide assemblies for bacterial infection imaging and treatment

Zhou,

Xu,

Sun

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

Section: In Situ Peptide Assemblies For Bacterial Infection Imagingmentioning

confidence: 99%

In situ peptide assemblies for bacterial infection imaging and treatment

Zhou,

Xu,

Sun

et al. 2024

Nanoscale

View full text Add to dashboard Cite

show abstract

“…A potential mechanism for the bacterial suppression of CS/Ag NPs is shown in Figure 5g. One of the two fundamental processes that may be responsible for the inhibition action of Ag-based NPs is the breakdown of cell walls and membrane destruction (1). The attraction and interaction between NPs and bacteria begin with Ag adhesion to the plasma membrane, which causes membrane structural alterations, resulting in membrane depolarization, disruption of permeability, and disruption of cell wall integrity.…”

Section: Dual Fluorescent Stainingmentioning

confidence: 99%

“…Infectious diseases are the leading cause of premature death on a global scale [ 1 , 2 ]. At the same time, cancer is the second leading cause of early death globally [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

et al. 2023

View full text Add to dashboard Cite

In the treatment of bacterial contamination, the problem of multi-drug resistance is becoming an increasingly pressing concern. Nanotechnology advancements enable the preparation of metal nanoparticles that can be assembled into complex systems to control bacterial and tumor cell growth. The current work investigates the green production of chitosan functionalized silver nanoparticles (CS/Ag NPs) using Sida acuta and their inhibition efficacy against bacterial pathogens and lung cancer cells (A549). Initially, a brown color formation confirmed the synthesis, and the chemical nature of the synthesized NPs were examined by UV-vis spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) coupled with energy dispersive spectroscopy (EDS), and transmission electron microscopy (TEM). FTIR demonstrated the occurrence of CS and S. acuta functional groups in the synthesized CS/Ag NPs. The electron microscopy study exhibited CS/Ag NPs with a spherical morphology and size ranges of 6–45 nm, while XRD analysis demonstrated the crystallinity of Ag NPs. Further, the bacterial inhibition property of CS/Ag NPs was examined against K. pneumoniae and S. aureus, which showed clear inhibition zones at different concentrations. In addition, the antibacterial properties were further confirmed by a fluorescent AO/EtBr staining technique. Furthermore, prepared CS/Ag NPs exhibited a potential anti-cancer character against a human lung cancer cell line (A549). In conclusion, our findings revealed that the produced CS/Ag NPs could be used as an excellent inhibitory material in industrial and clinical sectors.

show abstract

Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Hu,

Fang,

Zhu

et al. 2024

Adv Funct Materials

View full text Add to dashboard Cite

Fluorescence imaging in the second near‐infrared window (NIR‐II, 1000–1700 nm) has aroused immense attention for biomedical applications, offering exceptional advantages such as ultra‐low photon scattering and increased tissue penetration. Among the NIR‐II‐emitted organic dyes, Boron dipyrromethene (BODIPY), has emerged as a noteworthy candidate. BODIPY, distinguished by its controllable molecular structure and optical properties, outstanding fluorescence quantum yields, high molar absorption coefficients, and remarkable chemical stability, has undergone comprehensive investigation and extensive exploration within the realm of biological theranostics. This work aims to provide a comprehensive summary of the advancements in the development and design strategies of NIR‐II BODIPY fluorophores tailored for advanced biological phototheranostics. Initially, the work elucidates several representative and controllable strategies, concluding the electron‐programming strategy, extension of the conjugated backbone, J‐aggregation strategy, and strategic establishment of activatable fluorophores, which enhance the NIR‐II fluorescence of BODIPY skeletons. Subsequently, developments in NIR‐II fluorescent BODIPY‐based nanoplatforms for biological applications are intricately elaborated. In conclusion, this work outlines future efforts and directions for refining NIR‐II BODIPY to meet evolving clinical demands. It is anticipated that this contribution may provide a feasible reference for the strategic design of organic NIR‐II fluorophores, thereby advancing their potential in future clinical practices.

show abstract

Research progress of contrast agents for bacterial infection imaging in vivo

Cited by 7 publications

References 99 publications

In situ peptide assemblies for bacterial infection imaging and treatment

In situ peptide assemblies for bacterial infection imaging and treatment

Facile Synthesis and Characterization of Chitosan Functionalized Silver Nanoparticles for Antibacterial and Anti-Lung Cancer Applications

Crucial Breakthrough of BODIPY‐Based NIR‐II Fluorescent Emitters for Advanced Biomedical Theranostics

Contact Info

Product

Resources

About