Research Progress of Circular RNA in Gastrointestinal Tumors

Fang, Na; Ding, Guowen; Ding, Hao; Li, Juan; Liu, Chao; Lv, Le; Shi, Yijun

doi:10.3389/fonc.2021.665246

Cited by 6 publications

(4 citation statements)

References 135 publications

(131 reference statements)

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“…At present, dye leakage method, microbial infiltration method, fluid filtration method, electrochemical method, glucose leakage method, scanning electron microscope [28] are different detection methods used to evaluate dental microleakage. Due to the different theories of these methods, their results cannot be compared with each other.…”

Section: Detection and Evaluation Of Microleakagementioning

confidence: 99%

Influencing factors and detection methods of microleakage in root canal therapy

2023

IJFM

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Root canal therapy is a common and effective method to treat pulp and periapical diseases. Thorough root canal disinfection, good root canal shaping, perfect crown seal and apical seal are the keys to successful root canal treatment. The failure of root canal treatment can be attributed to the microleakage of bacteria and other irritants into the root canal and periapical tissues when the root canal system is not tightly filled. This paper will discuss the influencing factors of microleakage in root canal therapy and the research progress of microleakage detection methods.

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Section: Detection and Evaluation Of Microleakagementioning

confidence: 99%

Influencing factors and detection methods of microleakage in root canal therapy

2023

IJFM

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“…CircRNAs, first found in the 1890s [128], remain enigmatic owing to technological limitations and limited existing knowledge. In 2013, Hansen TB et al first proposed and confirmed that circRNAs function as miRNA sponges [129].…”

Section: Circrna In the Wnt Pathwaymentioning

confidence: 99%

The functional roles of the circRNA/Wnt axis in cancer

Xue

Zheng

et al. 2022

Mol Cancer

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CircRNAs, covalently closed noncoding RNAs, are widely expressed in a wide range of species ranging from viruses to plants to mammals. CircRNAs were enriched in the Wnt pathway. Aberrant Wnt pathway activation is involved in the development of various types of cancers. Accumulating evidence indicates that the circRNA/Wnt axis modulates the expression of cancer-associated genes and then regulates cancer progression. Wnt pathway-related circRNA expression is obviously associated with many clinical characteristics. CircRNAs could regulate cell biological functions by interacting with the Wnt pathway. Moreover, Wnt pathway-related circRNAs are promising potential biomarkers for cancer diagnosis, prognosis evaluation, and treatment. In our review, we summarized the recent research progress on the role and clinical application of Wnt pathway-related circRNAs in tumorigenesis and progression.

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“…Gastrointestinal (GI) cancers are among the most important causes of cancer-related death worldwide and mainly include colorectal cancer (CRC), gastric cancer (GC) and esophageal cancer (EC) (Wang D.-K. et al, 2021). These GI cancers pose a huge threat to human health worldwide (Fang et al, 2021). Conventional treatments, including chemotherapy, radiotherapy and surgery, have been the mainstays of cancer therapy (Buckley et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

The Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer

Wang

Zhang

et al. 2022

Front. Cell Dev. Biol.

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Gastrointestinal (GI) cancer represents a major global health problem due to its aggressive characteristics and poor prognosis. Despite the progress achieved in the development of treatment regimens, the clinical outcomes and therapeutic responses of patients with GI cancer remain unsatisfactory. Chemoresistance arising throughout the clinical intervention is undoubtedly a critical barrier for the successful treatment of GI cancer. However, the precise mechanisms associated with chemoresistance in GI cancer remain unclear. In the past decade, accumulating evidence has indicated that circular RNAs (circRNAs) play a key role in regulating cancer progression and chemoresistance. Notably, circRNAs function as molecular sponges that sequester microRNAs (miRNAs) and/or proteins, and thus indirectly control the expression of specific genes, which eventually promote or suppress drug resistance in GI cancer. Therefore, circRNAs may represent potential therapeutic targets for overcoming drug resistance in patients with GI cancer. This review comprehensively summarizes the regulatory roles of circRNAs in the development of chemoresistance in different GI cancers, including colorectal cancer, gastric cancer and esophageal cancer, as well as deciphers the underlying mechanisms and key molecules involved. Increasing knowledge of the important functions of circRNAs underlying drug resistance will provide new opportunities for developing efficacious therapeutic strategies against GI cancer.

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Research Progress of Circular RNA in Gastrointestinal Tumors

Cited by 6 publications

References 135 publications

Influencing factors and detection methods of microleakage in root canal therapy

Influencing factors and detection methods of microleakage in root canal therapy

The functional roles of the circRNA/Wnt axis in cancer

The Emerging Roles of Circular RNAs in the Chemoresistance of Gastrointestinal Cancer

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