Research Progress of Chiral MOFs in Chiral Resolution

Abstract

Chiral separation is important for drug development, and chiral resolution is one of the most popular methods for chiral separation. Metal organic framework materials (MOFs), with their regular and adjustable porous structures, can be an efficient and selective platform for chiral recognition and separation by assigning highly ordered chiral recognition sites to MOFs with large specific surface area and high stability. This paper reviews the recent literature on the synthesis and application of chiral MOFs and the preparation and application of MOFs composites. Firstly, the progress of MOFs synthesis methods in recent years is introduced, followed by the progress of the application of post-functionalized chiral MOFs in chiral resolution, and then the progress of the preparation and application of MOFs complexes is also introduced. Finally, the limitations and developments of chiral MOFs in chiral drug resolution are briefly described in this paper.